10-K Filing

AGIOS PHARMACEUTICALS, INC. CIK: 1439222 FY 2017

Filing Information

Form Type	10-K
Accession Number	`0001439222-18-000004`
Period End Date	20171231
Filing Date	20180214
Fiscal Year	2017
Fiscal Period	FY
XBRL Instance	agio-20171231.xml

Filing Contents

This filing contains the following financial statements:

Balance Sheet 74 Income Statement 60 Cash Flow Statement 91 Stockholders Equity 28 Comprehensive Income 9

Balance Sheet 74 line items

Line Item	Tag	Value	Unit	Period
Preferred stock, par value (in usd per share)	`PreferredStockParOrStatedValuePerShare`	$0.00	USD	Point-in-time
Preferred stock, par value (in usd per share)	`PreferredStockParOrStatedValuePerShare`	$0.00	USD	Point-in-time
Preferred stock, shares authorized (in shares)	`PreferredStockSharesAuthorized`	25.00M	shares	Point-in-time
Preferred stock, shares authorized (in shares)	`PreferredStockSharesAuthorized`	25.00M	shares	Point-in-time
Cash and cash equivalents	`CashAndCashEquivalentsAtCarryingValue`	$160.75M	USD	Point-in-time
Preferred stock, shares issued (in shares)	`PreferredStockSharesIssued`	0.00	shares	Point-in-time
Cash and cash equivalents	`CashAndCashEquivalentsAtCarryingValue`	$14.03M	USD	Point-in-time
Preferred stock, shares issued (in shares)	`PreferredStockSharesIssued`	0.00	shares	Point-in-time
Cash and cash equivalents	`CashAndCashEquivalentsAtCarryingValue`	$102.72M	USD	Point-in-time
Cash and cash equivalents	`CashAndCashEquivalentsAtCarryingValue`	$71.76M	USD	Point-in-time
Preferred stock, shares outstanding (in shares)	`PreferredStockSharesOutstanding`	0.00	shares	Point-in-time
Preferred stock, shares outstanding (in shares)	`PreferredStockSharesOutstanding`	0.00	shares	Point-in-time
Marketable securities	`AvailableForSaleSecuritiesCurrent`	$321.21M	USD	Point-in-time
Marketable securities	`AvailableForSaleSecuritiesCurrent`	$380.56M	USD	Point-in-time
Collaboration receivable related party	`CollaborationReceivableDuefromRelatedPartiesCurrent`	$4.89M	USD	Point-in-time
Common stock, par value (in usd per share)	`CommonStockParOrStatedValuePerShare`	$0.00	USD	Point-in-time
Collaboration receivable related party	`CollaborationReceivableDuefromRelatedPartiesCurrent`	$2.45M	USD	Point-in-time
Common stock, par value (in usd per share)	`CommonStockParOrStatedValuePerShare`	$0.00	USD	Point-in-time
Royalty receivable related party	`RoyaltyReceivableDuefromRelatedPartiesCurrent`	$1.22M	USD	Point-in-time
Royalty receivable related party	`RoyaltyReceivableDuefromRelatedPartiesCurrent`	-	USD	Point-in-time
Common stock, shares authorized (in shares)	`CommonStockSharesAuthorized`	125.00M	shares	Point-in-time
Common stock, shares authorized (in shares)	`CommonStockSharesAuthorized`	125.00M	shares	Point-in-time
Common stock, shares issued (in shares)	`CommonStockSharesIssued`	42.22M	shares	Point-in-time
Tenant improvement and other receivables	`AccountsAndOtherReceivablesNetCurrent`	$169.00K	USD	Point-in-time
Tenant improvement and other receivables	`AccountsAndOtherReceivablesNetCurrent`	$3.43M	USD	Point-in-time
Common stock, shares issued (in shares)	`CommonStockSharesIssued`	48.83M	shares	Point-in-time
Prepaid expenses and other current assets	`PrepaidExpenseAndOtherAssetsCurrent`	$10.26M	USD	Point-in-time
Prepaid expenses and other current assets	`PrepaidExpenseAndOtherAssetsCurrent`	$17.49M	USD	Point-in-time
Common stock, shares outstanding (in shares)	`CommonStockSharesOutstanding`	42.22M	shares	Point-in-time
Common stock, shares outstanding (in shares)	`CommonStockSharesOutstanding`	48.83M	shares	Point-in-time
Total current assets	`AssetsCurrent`	$559.89M	USD	Point-in-time
Total current assets	`AssetsCurrent`	$445.26M	USD	Point-in-time
Marketable securities	`AvailableForSaleSecuritiesNoncurrent`	$32.25M	USD	Point-in-time
Marketable securities	`AvailableForSaleSecuritiesNoncurrent`	$143.81M	USD	Point-in-time
Property and equipment, net	`PropertyPlantAndEquipmentNet`	$24.43M	USD	Point-in-time
Property and equipment, net	`PropertyPlantAndEquipmentNet`	$25.34M	USD	Point-in-time
Other non-current assets	`OtherAssetsNoncurrent`	$1.61M	USD	Point-in-time
Other non-current assets	`OtherAssetsNoncurrent`	$891.00K	USD	Point-in-time
Total assets	`Assets`	$614.40M	USD	Point-in-time
Total assets	`Assets`	$619.09M	USD	Point-in-time
Accounts payable	`AccountsPayableCurrent`	$22.77M	USD	Point-in-time
Accounts payable	`AccountsPayableCurrent`	$17.11M	USD	Point-in-time
Accrued expenses	`AccruedLiabilitiesCurrent`	$34.03M	USD	Point-in-time
Accrued expenses	`AccruedLiabilitiesCurrent`	$32.00M	USD	Point-in-time
Deferred revenue related party	`DeferredRevenueCurrent`	$35.91M	USD	Point-in-time
Deferred revenue related party	`DeferredRevenueCurrent`	$37.84M	USD	Point-in-time
Deferred rent	`DeferredRentCreditCurrent`	$3.41M	USD	Point-in-time
Deferred rent	`DeferredRentCreditCurrent`	$301.00K	USD	Point-in-time
Total current liabilities	`LiabilitiesCurrent`	$88.43M	USD	Point-in-time
Total current liabilities	`LiabilitiesCurrent`	$94.94M	USD	Point-in-time
Deferred revenue, net of current portion related party	`DeferredRevenueNoncurrent`	$125.80M	USD	Point-in-time
Deferred revenue, net of current portion related party	`DeferredRevenueNoncurrent`	$154.30M	USD	Point-in-time
Deferred rent, net of current portion	`DeferredRentCreditNoncurrent`	$17.77M	USD	Point-in-time
Deferred rent, net of current portion	`DeferredRentCreditNoncurrent`	$18.16M	USD	Point-in-time
Total liabilities	`Liabilities`	$260.50M	USD	Point-in-time
Total liabilities	`Liabilities`	$238.89M	USD	Point-in-time
Commitments and contingent liabilities (Note 7)	`CommitmentsAndContingencies`	-	USD	Point-in-time
Commitments and contingent liabilities (Note 7)	`CommitmentsAndContingencies`	-	USD	Point-in-time
Preferred stock, $0.001 par value; 25,000,000 shares authorized, no shares issued and outstanding at December 31, 2017 and 2016	`PreferredStockValue`	-	USD	Point-in-time
Preferred stock, $0.001 par value; 25,000,000 shares authorized, no shares issued and outstanding at December 31, 2017 and 2016	`PreferredStockValue`	-	USD	Point-in-time
Common stock, $0.001 par value; 125,000,000 shares authorized and 48,826,153 and 42,220,444 shares issued and outstanding at December 31, 2017 and 2016, respectively	`CommonStockValue`	$42.00K	USD	Point-in-time
Common stock, $0.001 par value; 125,000,000 shares authorized and 48,826,153 and 42,220,444 shares issued and outstanding at December 31, 2017 and 2016, respectively	`CommonStockValue`	$49.00K	USD	Point-in-time
Additional paid-in capital	`AdditionalPaidInCapitalCommonStock`	$1.17B	USD	Point-in-time
Additional paid-in capital	`AdditionalPaidInCapitalCommonStock`	$842.01M	USD	Point-in-time
Accumulated other comprehensive loss	`AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax`	$-313.00K	USD	Point-in-time
Accumulated other comprehensive loss	`AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax`	$-1.39M	USD	Point-in-time
Accumulated deficit	`RetainedEarningsAccumulatedDeficit`	$-483.15M	USD	Point-in-time
Accumulated deficit	`RetainedEarningsAccumulatedDeficit`	$-798.06M	USD	Point-in-time
Total stockholders equity	`StockholdersEquity`	$375.50M	USD	Point-in-time
Total stockholders equity	`StockholdersEquity`	$358.59M	USD	Point-in-time
Total stockholders equity	`StockholdersEquity`	$345.12M	USD	Point-in-time
Total stockholders equity	`StockholdersEquity`	$424.37M	USD	Point-in-time
Total liabilities and stockholders equity	`LiabilitiesAndStockholdersEquity`	$614.40M	USD	Point-in-time
Total liabilities and stockholders equity	`LiabilitiesAndStockholdersEquity`	$619.09M	USD	Point-in-time

Income Statement 60 line items

Line Item	Tag	Value	Unit	Period
Collaboration revenue related party	`LicenseAndServicesRevenue`	$69.89M	USD	Annual
Reduction of research and development costs	`ResearchAndDevelopmentArrangementContractToPerformForOthersCompensationEarned`	$7.81M	USD	Annual
Collaboration revenue related party	`LicenseAndServicesRevenue`	$41.07M	USD	Annual
Reduction of research and development costs	`ResearchAndDevelopmentArrangementContractToPerformForOthersCompensationEarned`	$19.71M	USD	Annual
Collaboration revenue related party	`LicenseAndServicesRevenue`	$59.12M	USD	Annual
Reduction of research and development costs	`ResearchAndDevelopmentArrangementContractToPerformForOthersCompensationEarned`	$25.17M	USD	Annual
Royalty revenue related party	`RoyaltyRevenue`	-	USD	Annual
Royalty revenue related party	`RoyaltyRevenue`	-	USD	Annual
Royalty revenue related party	`RoyaltyRevenue`	$1.94M	USD	Annual
Total revenue	`Revenues`	$6.98M	USD	1 Quarter
Total revenue	`Revenues`	$8.98M	USD	1 Quarter
Total revenue	`Revenues`	$10.51M	USD	1 Quarter
Total revenue	`Revenues`	$59.12M	USD	Annual
Total revenue	`Revenues`	$11.36M	USD	1 Quarter
Total revenue	`Revenues`	$31.28M	USD	1 Quarter
Total revenue	`Revenues`	$9.80M	USD	1 Quarter
Total revenue	`Revenues`	$69.89M	USD	Annual
Total revenue	`Revenues`	$11.35M	USD	1 Quarter
Total revenue	`Revenues`	$43.01M	USD	Annual
Total revenue	`Revenues`	$22.65M	USD	1 Quarter
Research and development (net of $7,811, $19,714 and $25,173 of cost reimbursement from related party for the years ended December 31, 2017, 2016 and 2015, respectively)	`ResearchAndDevelopmentExpense`	$220.16M	USD	Annual
Research and development (net of $7,811, $19,714 and $25,173 of cost reimbursement from related party for the years ended December 31, 2017, 2016 and 2015, respectively)	`ResearchAndDevelopmentExpense`	$141.83M	USD	Annual
Research and development (net of $7,811, $19,714 and $25,173 of cost reimbursement from related party for the years ended December 31, 2017, 2016 and 2015, respectively)	`ResearchAndDevelopmentExpense`	$292.68M	USD	Annual
General and administrative	`GeneralAndAdministrativeExpense`	$50.71M	USD	Annual
General and administrative	`GeneralAndAdministrativeExpense`	$71.12M	USD	Annual
General and administrative	`GeneralAndAdministrativeExpense`	$35.99M	USD	Annual
Total operating expenses	`OperatingExpenses`	$363.81M	USD	Annual
Total operating expenses	`OperatingExpenses`	$270.88M	USD	Annual
Total operating expenses	`OperatingExpenses`	$177.82M	USD	Annual
Loss from operations	`OperatingIncomeLoss`	$-63.51M	USD	1 Quarter
Loss from operations	`OperatingIncomeLoss`	$-320.79M	USD	Annual
Loss from operations	`OperatingIncomeLoss`	$-90.13M	USD	1 Quarter
Loss from operations	`OperatingIncomeLoss`	$-67.05M	USD	1 Quarter
Loss from operations	`OperatingIncomeLoss`	$-56.47M	USD	1 Quarter
Loss from operations	`OperatingIncomeLoss`	$-84.60M	USD	1 Quarter
Loss from operations	`OperatingIncomeLoss`	$-57.41M	USD	1 Quarter
Loss from operations	`OperatingIncomeLoss`	$-200.99M	USD	Annual
Loss from operations	`OperatingIncomeLoss`	$-118.70M	USD	Annual
Loss from operations	`OperatingIncomeLoss`	$-79.02M	USD	1 Quarter
Loss from operations	`OperatingIncomeLoss`	$-23.59M	USD	1 Quarter
Interest income	`InvestmentIncomeInterest`	$2.51M	USD	Annual
Interest income	`InvestmentIncomeInterest`	$6.12M	USD	Annual
Interest income	`InvestmentIncomeInterest`	$968.00K	USD	Annual
Net loss	`NetIncomeLoss`	$-198.47M	USD	Annual
Net loss	`NetIncomeLoss`	$-314.67M	USD	Annual
Net loss	`NetIncomeLoss`	$-117.73M	USD	Annual
Net loss per share - basic and diluted (in usd per share)	`EarningsPerShareBasicAndDiluted`	$-6.75	USD	Annual
Net loss per share - basic and diluted (in usd per share)	`EarningsPerShareBasicAndDiluted`	$-1.59	USD	1 Quarter
Net loss per share - basic and diluted (in usd per share)	`EarningsPerShareBasicAndDiluted`	$-1.63	USD	1 Quarter
Net loss per share - basic and diluted (in usd per share)	`EarningsPerShareBasicAndDiluted`	$-1.78	USD	1 Quarter
Net loss per share - basic and diluted (in usd per share)	`EarningsPerShareBasicAndDiluted`	$-5.07	USD	Annual
Net loss per share - basic and diluted (in usd per share)	`EarningsPerShareBasicAndDiluted`	$-1.47	USD	1 Quarter
Net loss per share - basic and diluted (in usd per share)	`EarningsPerShareBasicAndDiluted`	$-3.15	USD	Annual
Net loss per share - basic and diluted (in usd per share)	`EarningsPerShareBasicAndDiluted`	$-1.56	USD	1 Quarter
Net loss per share - basic and diluted (in usd per share)	`EarningsPerShareBasicAndDiluted`	$-1.34	USD	1 Quarter
Net loss per share - basic and diluted (in usd per share)	`EarningsPerShareBasicAndDiluted`	$-0.61	USD	1 Quarter
Net loss per share - basic and diluted (in usd per share)	`EarningsPerShareBasicAndDiluted`	$-1.81	USD	1 Quarter
Weighted-average number of common shares used in computing net loss per share - basic and diluted (in shares)	`WeightedAverageNumberOfShareOutstandingBasicAndDiluted`	39.13M	shares	Annual
Weighted-average number of common shares used in computing net loss per share - basic and diluted (in shares)	`WeightedAverageNumberOfShareOutstandingBasicAndDiluted`	46.59M	shares	Annual
Weighted-average number of common shares used in computing net loss per share - basic and diluted (in shares)	`WeightedAverageNumberOfShareOutstandingBasicAndDiluted`	37.43M	shares	Annual

Cash Flow Statement 91 line items

Line Item	Tag	Value	Unit	Period
Net loss	`NetIncomeLoss`	$-198.47M	USD	Annual
Net loss	`NetIncomeLoss`	$-314.67M	USD	Annual
Net loss	`NetIncomeLoss`	$-117.73M	USD	Annual
Depreciation	`Depreciation`	$6.43M	USD	Annual
Depreciation	`Depreciation`	$5.71M	USD	Annual
Depreciation	`Depreciation`	$3.34M	USD	Annual
Loss on disposal of property and equipment	`GainLossOnDispositionOfAssets1`	$-40.00K	USD	Annual
Loss on disposal of property and equipment	`GainLossOnDispositionOfAssets1`	-	USD	Annual
Loss on disposal of property and equipment	`GainLossOnDispositionOfAssets1`	$-33.00K	USD	Annual
Stock-based compensation expense	`ShareBasedCompensation`	$31.96M	USD	Annual
Stock-based compensation expense	`ShareBasedCompensation`	$42.09M	USD	Annual
Stock-based compensation expense	`ShareBasedCompensation`	$47.81M	USD	Annual
Net (accretion of discount) amortization of premium on marketable securities	`AccretionAmortizationOfDiscountsAndPremiumsInvestments`	$-539.00K	USD	Annual
Net (accretion of discount) amortization of premium on marketable securities	`AccretionAmortizationOfDiscountsAndPremiumsInvestments`	$11.00K	USD	Annual
Net (accretion of discount) amortization of premium on marketable securities	`AccretionAmortizationOfDiscountsAndPremiumsInvestments`	$-773.00K	USD	Annual
Collaboration receivable related party	`IncreaseDecreaseinCollaborationReceivableDuefromRelatedPartiesCurrent`	$-3.34M	USD	Annual
Collaboration receivable related party	`IncreaseDecreaseinCollaborationReceivableDuefromRelatedPartiesCurrent`	$1.73M	USD	Annual
Collaboration receivable related party	`IncreaseDecreaseinCollaborationReceivableDuefromRelatedPartiesCurrent`	$-2.44M	USD	Annual
Royalty receivable related party	`IncreaseDecreaseinRoyaltyReceivableDuefromRelatedPartiesCurrent`	-	USD	Annual
Royalty receivable related party	`IncreaseDecreaseinRoyaltyReceivableDuefromRelatedPartiesCurrent`	$1.22M	USD	Annual
Royalty receivable related party	`IncreaseDecreaseinRoyaltyReceivableDuefromRelatedPartiesCurrent`	-	USD	Annual
Tenant improvement and other receivables	`IncreaseDecreaseInAccountsAndOtherReceivables`	$-2.93M	USD	Annual
Tenant improvement and other receivables	`IncreaseDecreaseInAccountsAndOtherReceivables`	$-275.00K	USD	Annual
Tenant improvement and other receivables	`IncreaseDecreaseInAccountsAndOtherReceivables`	$1.04M	USD	Annual
Prepaid expenses and other current and non-current assets	`IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets`	$2.69M	USD	Annual
Prepaid expenses and other current and non-current assets	`IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets`	$3.77M	USD	Annual
Prepaid expenses and other current and non-current assets	`IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets`	$6.53M	USD	Annual
Accounts payable	`IncreaseDecreaseInAccountsPayable`	$4.21M	USD	Annual
Accounts payable	`IncreaseDecreaseInAccountsPayable`	$3.50M	USD	Annual
Accounts payable	`IncreaseDecreaseInAccountsPayable`	$5.33M	USD	Annual
Accrued expenses	`IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities`	$1.63M	USD	Annual
Accrued expenses	`IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities`	$1.52M	USD	Annual
Accrued expenses	`IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities`	$16.85M	USD	Annual
Deferred revenue related party	`IncreaseDecreaseInDeferredRevenue`	$-14.05M	USD	Annual
Deferred revenue related party	`IncreaseDecreaseInDeferredRevenue`	$165.85M	USD	Annual
Deferred revenue related party	`IncreaseDecreaseInDeferredRevenue`	$-26.57M	USD	Annual
Deferred rent	`IncreaseDecreaseInDeferredCharges`	$-15.80M	USD	Annual
Deferred rent	`IncreaseDecreaseInDeferredCharges`	$2.73M	USD	Annual
Deferred rent	`IncreaseDecreaseInDeferredCharges`	$-1.35M	USD	Annual
Refundable income taxes and income taxes payable	`IncreaseDecreaseInAccruedIncomeTaxesPayable`	$3.84M	USD	Annual
Refundable income taxes and income taxes payable	`IncreaseDecreaseInAccruedIncomeTaxesPayable`	-	USD	Annual
Net cash (used in) provided by operating activities	`NetCashProvidedByUsedInOperatingActivities`	$-285.23M	USD	Annual
Net cash (used in) provided by operating activities	`NetCashProvidedByUsedInOperatingActivities`	$-76.95M	USD	Annual
Net cash (used in) provided by operating activities	`NetCashProvidedByUsedInOperatingActivities`	$38.56M	USD	Annual
Purchases of marketable securities	`PaymentsToAcquireAvailableForSaleSecurities`	$353.18M	USD	Annual
Purchases of marketable securities	`PaymentsToAcquireAvailableForSaleSecurities`	$688.70M	USD	Annual
Purchases of marketable securities	`PaymentsToAcquireAvailableForSaleSecurities`	$506.07M	USD	Annual
Proceeds from maturities and sales of marketable securities	`ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities`	$635.42M	USD	Annual
Proceeds from maturities and sales of marketable securities	`ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities`	$396.63M	USD	Annual
Proceeds from maturities and sales of marketable securities	`ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities`	$501.65M	USD	Annual
Purchases of property and equipment	`PaymentsToAcquirePropertyPlantAndEquipment`	$20.16M	USD	Annual
Purchases of property and equipment	`PaymentsToAcquirePropertyPlantAndEquipment`	$4.63M	USD	Annual
Purchases of property and equipment	`PaymentsToAcquirePropertyPlantAndEquipment`	$9.91M	USD	Annual
Net cash (used in) provided by investing activities	`NetCashProvidedByUsedInInvestingActivities`	$-57.91M	USD	Annual
Net cash (used in) provided by investing activities	`NetCashProvidedByUsedInInvestingActivities`	$128.31M	USD	Annual
Net cash (used in) provided by investing activities	`NetCashProvidedByUsedInInvestingActivities`	$-119.35M	USD	Annual
Proceeds from public offering of common stock, net of commissions	`ProceedsFromIssuanceOfCommonStock`	-	USD	Annual
Proceeds from public offering of common stock, net of commissions	`ProceedsFromIssuanceOfCommonStock`	$270.20M	USD	Point-in-time
Proceeds from public offering of common stock, net of commissions	`ProceedsFromIssuanceOfCommonStock`	$270.25M	USD	Annual
Proceeds from public offering of common stock, net of commissions	`ProceedsFromIssuanceOfCommonStock`	$162.15M	USD	Annual
Reimbursement (payment) of public offering costs	`PaymentsOfStockIssuanceCosts`	$207.00K	USD	Annual
Reimbursement (payment) of public offering costs	`PaymentsOfStockIssuanceCosts`	$230.00K	USD	Annual
Reimbursement (payment) of public offering costs	`PaymentsOfStockIssuanceCosts`	$-638.00K	USD	Annual
Net proceeds from stock option exercises and employee stock purchase plan, and vesting of restricted stock units	`ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions`	$6.58M	USD	Annual
Net proceeds from stock option exercises and employee stock purchase plan, and vesting of restricted stock units	`ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions`	$14.22M	USD	Annual
Net proceeds from stock option exercises and employee stock purchase plan, and vesting of restricted stock units	`ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions`	$7.86M	USD	Annual
Net cash provided by financing activities	`NetCashProvidedByUsedInFinancingActivities`	$169.78M	USD	Annual
Net cash provided by financing activities	`NetCashProvidedByUsedInFinancingActivities`	$6.37M	USD	Annual
Net cash provided by financing activities	`NetCashProvidedByUsedInFinancingActivities`	$285.11M	USD	Annual
Net change in cash and cash equivalents	`CashAndCashEquivalentsPeriodIncreaseDecrease`	$88.99M	USD	Annual
Net change in cash and cash equivalents	`CashAndCashEquivalentsPeriodIncreaseDecrease`	$57.73M	USD	Annual
Net change in cash and cash equivalents	`CashAndCashEquivalentsPeriodIncreaseDecrease`	$-58.03M	USD	Annual
Cash and cash equivalents at beginning of the period	`CashAndCashEquivalentsAtCarryingValue`	$160.75M	USD	Point-in-time
Cash and cash equivalents at beginning of the period	`CashAndCashEquivalentsAtCarryingValue`	$14.03M	USD	Point-in-time
Cash and cash equivalents at beginning of the period	`CashAndCashEquivalentsAtCarryingValue`	$102.72M	USD	Point-in-time
Cash and cash equivalents at beginning of the period	`CashAndCashEquivalentsAtCarryingValue`	$71.76M	USD	Point-in-time
Cash and cash equivalents at end of the period	`CashAndCashEquivalentsAtCarryingValue`	$160.75M	USD	Point-in-time
Cash and cash equivalents at end of the period	`CashAndCashEquivalentsAtCarryingValue`	$14.03M	USD	Point-in-time
Cash and cash equivalents at end of the period	`CashAndCashEquivalentsAtCarryingValue`	$102.72M	USD	Point-in-time
Cash and cash equivalents at end of the period	`CashAndCashEquivalentsAtCarryingValue`	$71.76M	USD	Point-in-time
Vesting of restricted stock	`VestingOfRestrictedStockValueIncreaseDecrease`	-	USD	Annual
Vesting of restricted stock	`VestingOfRestrictedStockValueIncreaseDecrease`	$6.00K	USD	Annual
Additions to property and equipment in accounts payable and accrued expenses	`CapitalExpendituresIncurredButNotYetPaid`	$1.01M	USD	Annual
Additions to property and equipment in accounts payable and accrued expenses	`CapitalExpendituresIncurredButNotYetPaid`	$2.16M	USD	Annual
Additions to property and equipment in accounts payable and accrued expenses	`CapitalExpendituresIncurredButNotYetPaid`	$73.00K	USD	Annual
Proceeds from stock option exercises in other receivables	`ProceedsFromStockOptionsExercisedInOtherCurrentAssets`	$32.00K	USD	Annual
Proceeds from stock option exercises in other receivables	`ProceedsFromStockOptionsExercisedInOtherCurrentAssets`	-	USD	Annual
Proceeds from stock option exercises in other receivables	`ProceedsFromStockOptionsExercisedInOtherCurrentAssets`	$186.00K	USD	Annual
Public offering costs in other receivables, net of amounts in accounts payable and accrued expenses	`PublicOfferingCostsInOtherCurrentAssets`	$230.00K	USD	Annual
Public offering costs in other receivables, net of amounts in accounts payable and accrued expenses	`PublicOfferingCostsInOtherCurrentAssets`	-	USD	Annual
Public offering costs in other receivables, net of amounts in accounts payable and accrued expenses	`PublicOfferingCostsInOtherCurrentAssets`	-	USD	Annual

Stockholders Equity 28 line items

Line Item	Tag	Value	Unit	Period
Beginning balance	`StockholdersEquity`	$375.50M	USD	Point-in-time
Beginning balance	`StockholdersEquity`	$358.59M	USD	Point-in-time
Beginning balance	`StockholdersEquity`	$345.12M	USD	Point-in-time
Beginning balance	`StockholdersEquity`	$424.37M	USD	Point-in-time
Unrealized (loss) gain on available-for-sale securities	`OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax`	$-1.08M	USD	Annual
Unrealized (loss) gain on available-for-sale securities	`OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax`	$-261.00K	USD	Annual
Unrealized (loss) gain on available-for-sale securities	`OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax`	$5.00K	USD	Annual
Net loss	`NetIncomeLoss`	$-198.47M	USD	Annual
Net loss	`NetIncomeLoss`	$-314.67M	USD	Annual
Net loss	`NetIncomeLoss`	$-117.73M	USD	Annual
Stock-based compensation expense	`AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue`	$31.57M	USD	Annual
Stock-based compensation expense	`AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue`	$42.09M	USD	Annual
Stock-based compensation expense	`AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue`	$47.81M	USD	Annual
Vesting of restricted stock (in shares)	`ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod`	7,500.00	shares	Annual
Vesting of restricted stock	`AdjustmentsToAdditionalPaidInCapitalShareBasedCompensationRestrictedStockUnitsRequisiteServicePeriodRecognition`	$6.00K	USD	Annual
Issuance of common stock upon exercise of stock options and employee stock purchase plan (in shares)	`StockIssuedDuringPeriodSharesStockOptionsExercised`	730,478.00	shares	Annual
Issuance of common stock under stock incentive and employee stock purchase plans	`StockIssuedDuringPeriodValueStockOptionsExercised`	$7.14M	USD	Annual
Issuance of common stock under stock incentive and employee stock purchase plans	`StockIssuedDuringPeriodValueStockOptionsExercised`	$14.19M	USD	Annual
Issuance of common stock under stock incentive and employee stock purchase plans	`StockIssuedDuringPeriodValueStockOptionsExercised`	$7.70M	USD	Annual
Issuance of common stock for follow-on offering (in shares)	`StockIssuedDuringPeriodSharesNewIssues`	5.81M	shares	Point-in-time
Issuance of common stock for follow-on offering	`StockIssuedDuringPeriodValueNewIssues`	$162.15M	USD	Annual
Issuance of common stock for follow-on offering	`StockIssuedDuringPeriodValueNewIssues`	$29.00K	USD	Annual
Issuance of common stock for follow-on offering	`StockIssuedDuringPeriodValueNewIssues`	$270.25M	USD	Annual
Other	`StockholdersEquityOther`	$409.00K	USD	Annual
Ending balance	`StockholdersEquity`	$375.50M	USD	Point-in-time
Ending balance	`StockholdersEquity`	$358.59M	USD	Point-in-time
Ending balance	`StockholdersEquity`	$345.12M	USD	Point-in-time
Ending balance	`StockholdersEquity`	$424.37M	USD	Point-in-time

Comprehensive Income 9 line items

Line Item	Tag	Value	Unit	Period
Net loss	`NetIncomeLoss`	$-198.47M	USD	Annual
Net loss	`NetIncomeLoss`	$-314.67M	USD	Annual
Net loss	`NetIncomeLoss`	$-117.73M	USD	Annual
Unrealized (loss) gain on available-for-sale securities	`OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax`	$-1.08M	USD	Annual
Unrealized (loss) gain on available-for-sale securities	`OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax`	$-261.00K	USD	Annual
Unrealized (loss) gain on available-for-sale securities	`OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax`	$5.00K	USD	Annual
Comprehensive loss	`ComprehensiveIncomeNetOfTax`	$-315.75M	USD	Annual
Comprehensive loss	`ComprehensiveIncomeNetOfTax`	$-117.99M	USD	Annual
Comprehensive loss	`ComprehensiveIncomeNetOfTax`	$-198.47M	USD	Annual

Data is extracted from SEC EDGAR XBRL filings. Values shown are as reported in the filing.