10-K Filing

AGIOS PHARMACEUTICALS, INC. CIK: 1439222 FY 2018

Filing Information

Form Type	10-K
Accession Number	`0001439222-19-000004`
Period End Date	20181231
Filing Date	20190214
Fiscal Year	2018
Fiscal Period	FY
XBRL Instance	agio-20181231_htm.xml

Filing Contents

This filing contains the following financial statements:

Balance Sheet 78 Income Statement 49 Cash Flow Statement 93 Stockholders Equity 27 Comprehensive Income 9

Balance Sheet 78 line items

Line Item	Tag	Value	Unit	Period
Preferred stock, par value (in usd per share)	`PreferredStockParOrStatedValuePerShare`	-	USD	Point-in-time
Preferred stock, par value (in usd per share)	`PreferredStockParOrStatedValuePerShare`	-	USD	Point-in-time
Preferred stock, shares authorized (in shares)	`PreferredStockSharesAuthorized`	25.00M	shares	Point-in-time
Preferred stock, shares authorized (in shares)	`PreferredStockSharesAuthorized`	25.00M	shares	Point-in-time
Cash and cash equivalents	`CashAndCashEquivalentsAtCarryingValue`	$71.76M	USD	Point-in-time
Cash and cash equivalents	`CashAndCashEquivalentsAtCarryingValue`	$160.75M	USD	Point-in-time
Preferred stock, shares issued (in shares)	`PreferredStockSharesIssued`	0.00	shares	Point-in-time
Cash and cash equivalents	`CashAndCashEquivalentsAtCarryingValue`	$70.50M	USD	Point-in-time
Preferred stock, shares issued (in shares)	`PreferredStockSharesIssued`	0.00	shares	Point-in-time
Cash and cash equivalents	`CashAndCashEquivalentsAtCarryingValue`	$102.72M	USD	Point-in-time
Preferred stock, shares outstanding (in shares)	`PreferredStockSharesOutstanding`	0.00	shares	Point-in-time
Marketable securities	`AvailableForSaleSecuritiesCurrent`	$514.80M	USD	Point-in-time
Preferred stock, shares outstanding (in shares)	`PreferredStockSharesOutstanding`	0.00	shares	Point-in-time
Marketable securities	`AvailableForSaleSecuritiesCurrent`	$321.21M	USD	Point-in-time
Accounts receivable, net	`ContractWithCustomerAssetNetCurrent`	$5.08M	USD	Point-in-time
Accounts receivable, net	`ContractWithCustomerAssetNetCurrent`	-	USD	Point-in-time
Common stock, par value (in usd per share)	`CommonStockParOrStatedValuePerShare`	-	USD	Point-in-time
Common stock, par value (in usd per share)	`CommonStockParOrStatedValuePerShare`	-	USD	Point-in-time
Collaboration receivable related party	`CollaborationReceivableDuefromRelatedPartiesCurrent`	$2.46M	USD	Point-in-time
Common stock, shares authorized (in shares)	`CommonStockSharesAuthorized`	125.00M	shares	Point-in-time
Collaboration receivable related party	`CollaborationReceivableDuefromRelatedPartiesCurrent`	$2.45M	USD	Point-in-time
Common stock, shares authorized (in shares)	`CommonStockSharesAuthorized`	125.00M	shares	Point-in-time
Common stock, shares issued (in shares)	`CommonStockSharesIssued`	58.22M	shares	Point-in-time
Collaboration receivable other	`CollaborationReceivableOtherCurrent`	-	USD	Point-in-time
Collaboration receivable other	`CollaborationReceivableOtherCurrent`	$670.00K	USD	Point-in-time
Common stock, shares issued (in shares)	`CommonStockSharesIssued`	48.83M	shares	Point-in-time
Royalty receivable related party	`RoyaltyReceivableDuefromRelatedPartiesCurrent`	$2.23M	USD	Point-in-time
Royalty receivable related party	`RoyaltyReceivableDuefromRelatedPartiesCurrent`	$1.22M	USD	Point-in-time
Common stock, shares outstanding (in shares)	`CommonStockSharesOutstanding`	58.22M	shares	Point-in-time
Common stock, shares outstanding (in shares)	`CommonStockSharesOutstanding`	48.83M	shares	Point-in-time
Inventory	`InventoryNet`	-	USD	Point-in-time
Inventory	`InventoryNet`	$869.00K	USD	Point-in-time
Prepaid expenses and other current assets	`PrepaidExpenseAndOtherAssetsCurrent`	$17.17M	USD	Point-in-time
Prepaid expenses and other current assets	`PrepaidExpenseAndOtherAssetsCurrent`	$17.66M	USD	Point-in-time
Total current assets	`AssetsCurrent`	$613.78M	USD	Point-in-time
Total current assets	`AssetsCurrent`	$445.26M	USD	Point-in-time
Marketable securities	`AvailableForSaleSecuritiesNoncurrent`	$143.81M	USD	Point-in-time
Marketable securities	`AvailableForSaleSecuritiesNoncurrent`	$220.12M	USD	Point-in-time
Property and equipment, net	`PropertyPlantAndEquipmentNet`	$24.32M	USD	Point-in-time
Property and equipment, net	`PropertyPlantAndEquipmentNet`	$24.43M	USD	Point-in-time
Other non-current assets	`OtherAssetsNoncurrent`	$238.00K	USD	Point-in-time
Other non-current assets	`OtherAssetsNoncurrent`	$891.00K	USD	Point-in-time
Total assets	`Assets`	$858.46M	USD	Point-in-time
Total assets	`Assets`	$614.40M	USD	Point-in-time
Accounts payable	`AccountsPayableCurrent`	$17.88M	USD	Point-in-time
Accounts payable	`AccountsPayableCurrent`	$22.77M	USD	Point-in-time
Accrued expenses	`AccruedLiabilitiesCurrent`	$42.15M	USD	Point-in-time
Accrued expenses	`AccruedLiabilitiesCurrent`	$34.03M	USD	Point-in-time
Deferred revenue related party	`ContractWithCustomerLiabilityCurrent`	$37.84M	USD	Point-in-time
Deferred revenue related party	`ContractWithCustomerLiabilityCurrent`	$32.71M	USD	Point-in-time
Deferred rent	`DeferredRentCreditCurrent`	$301.00K	USD	Point-in-time
Deferred rent	`DeferredRentCreditCurrent`	$766.00K	USD	Point-in-time
Total current liabilities	`LiabilitiesCurrent`	$94.94M	USD	Point-in-time
Total current liabilities	`LiabilitiesCurrent`	$93.50M	USD	Point-in-time
Deferred revenue, net of current portion related party	`ContractWithCustomerLiabilityNoncurrent`	$125.80M	USD	Point-in-time
Deferred revenue, net of current portion related party	`ContractWithCustomerLiabilityNoncurrent`	$59.81M	USD	Point-in-time
Deferred rent, net of current portion	`DeferredRentCreditNoncurrent`	$18.16M	USD	Point-in-time
Deferred rent, net of current portion	`DeferredRentCreditNoncurrent`	$17.61M	USD	Point-in-time
Total liabilities	`Liabilities`	$170.92M	USD	Point-in-time
Total liabilities	`Liabilities`	$238.89M	USD	Point-in-time
Commitments and contingent liabilities (Note 8)	`CommitmentsAndContingencies`	-	USD	Point-in-time
Commitments and contingent liabilities (Note 8)	`CommitmentsAndContingencies`	-	USD	Point-in-time
Preferred stock, $0.001 par value; 25,000,000 shares authorized, no shares issued and outstanding at December 31, 2018 and 2017	`PreferredStockValue`	-	USD	Point-in-time
Preferred stock, $0.001 par value; 25,000,000 shares authorized, no shares issued and outstanding at December 31, 2018 and 2017	`PreferredStockValue`	-	USD	Point-in-time
Common stock, $0.001 par value; 125,000,000 shares authorized and 58,218,651 and 48,826,153 shares issued and outstanding at December 31, 2018 and 2017, respectively	`CommonStockValue`	$58.00K	USD	Point-in-time
Common stock, $0.001 par value; 125,000,000 shares authorized and 58,218,651 and 48,826,153 shares issued and outstanding at December 31, 2018 and 2017, respectively	`CommonStockValue`	$49.00K	USD	Point-in-time
Additional paid-in capital	`AdditionalPaidInCapitalCommonStock`	$1.79B	USD	Point-in-time
Additional paid-in capital	`AdditionalPaidInCapitalCommonStock`	$1.17B	USD	Point-in-time
Accumulated other comprehensive loss	`AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax`	$-2.17M	USD	Point-in-time
Accumulated other comprehensive loss	`AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax`	$-1.39M	USD	Point-in-time
Accumulated deficit	`RetainedEarningsAccumulatedDeficit`	$-798.06M	USD	Point-in-time
Accumulated deficit	`RetainedEarningsAccumulatedDeficit`	$-1.10B	USD	Point-in-time
Total stockholders equity	`StockholdersEquity`	$687.54M	USD	Point-in-time
Total stockholders equity	`StockholdersEquity`	$358.59M	USD	Point-in-time
Total stockholders equity	`StockholdersEquity`	$375.50M	USD	Point-in-time
Total stockholders equity	`StockholdersEquity`	$345.12M	USD	Point-in-time
Total liabilities and stockholders equity	`LiabilitiesAndStockholdersEquity`	$614.40M	USD	Point-in-time
Total liabilities and stockholders equity	`LiabilitiesAndStockholdersEquity`	$858.46M	USD	Point-in-time

Income Statement 49 line items

Line Item	Tag	Value	Unit	Period
Reduction of research and development costs	`ResearchAndDevelopmentArrangementContractToPerformForOthersCompensationEarned`	$19.71M	USD	Annual
Reduction of research and development costs	`ResearchAndDevelopmentArrangementContractToPerformForOthersCompensationEarned`	-	USD	Annual
Reduction of research and development costs	`ResearchAndDevelopmentArrangementContractToPerformForOthersCompensationEarned`	$7.81M	USD	Annual
Revenues	`RevenueFromContractWithCustomerExcludingAssessedTax`	$94.39M	USD	Annual
Revenues	`RevenueFromContractWithCustomerExcludingAssessedTax`	$69.89M	USD	Annual
Revenues	`RevenueFromContractWithCustomerExcludingAssessedTax`	$43.01M	USD	Annual
Cost of sales	`CostOfGoodsAndServicesSold`	-	USD	Annual
Cost of sales	`CostOfGoodsAndServicesSold`	-	USD	Annual
Cost of sales	`CostOfGoodsAndServicesSold`	$1.40M	USD	Annual
Research and development expense	`ResearchAndDevelopmentExpense`	$220.16M	USD	Annual
Research and development expense	`ResearchAndDevelopmentExpense`	$292.68M	USD	Annual
Research and development expense	`ResearchAndDevelopmentExpense`	$341.32M	USD	Annual
Selling, general and administrative	`SellingGeneralAndAdministrativeExpense`	$50.71M	USD	Annual
Selling, general and administrative	`SellingGeneralAndAdministrativeExpense`	$71.12M	USD	Annual
Selling, general and administrative	`SellingGeneralAndAdministrativeExpense`	$114.14M	USD	Annual
Total cost and expenses	`OperatingExpenses`	$456.87M	USD	Annual
Total cost and expenses	`OperatingExpenses`	$270.88M	USD	Annual
Total cost and expenses	`OperatingExpenses`	$363.81M	USD	Annual
Loss from operations	`OperatingIncomeLoss`	$-79.02M	USD	1 Quarter
Loss from operations	`OperatingIncomeLoss`	$-72.95M	USD	1 Quarter
Loss from operations	`OperatingIncomeLoss`	$-96.36M	USD	1 Quarter
Loss from operations	`OperatingIncomeLoss`	$-362.48M	USD	Annual
Loss from operations	`OperatingIncomeLoss`	$-99.16M	USD	1 Quarter
Loss from operations	`OperatingIncomeLoss`	$-90.13M	USD	1 Quarter
Loss from operations	`OperatingIncomeLoss`	$-320.79M	USD	Annual
Loss from operations	`OperatingIncomeLoss`	$-67.05M	USD	1 Quarter
Loss from operations	`OperatingIncomeLoss`	$-200.99M	USD	Annual
Loss from operations	`OperatingIncomeLoss`	$-84.60M	USD	1 Quarter
Loss from operations	`OperatingIncomeLoss`	$-94.01M	USD	1 Quarter
Interest income	`InvestmentIncomeInterest`	$2.51M	USD	Annual
Interest income	`InvestmentIncomeInterest`	$6.12M	USD	Annual
Interest income	`InvestmentIncomeInterest`	$16.45M	USD	Annual
Net loss	`NetIncomeLoss`	$-314.67M	USD	Annual
Net loss	`NetIncomeLoss`	$-198.47M	USD	Annual
Net loss	`NetIncomeLoss`	$-346.03M	USD	Annual
Net loss per share - basic and diluted (in usd per share)	`EarningsPerShareBasicAndDiluted`	$-1.58	USD	1 Quarter
Net loss per share - basic and diluted (in usd per share)	`EarningsPerShareBasicAndDiluted`	$-6.03	USD	Annual
Net loss per share - basic and diluted (in usd per share)	`EarningsPerShareBasicAndDiluted`	$-1.63	USD	1 Quarter
Net loss per share - basic and diluted (in usd per share)	`EarningsPerShareBasicAndDiluted`	$-1.81	USD	1 Quarter
Net loss per share - basic and diluted (in usd per share)	`EarningsPerShareBasicAndDiluted`	$-1.56	USD	1 Quarter
Net loss per share - basic and diluted (in usd per share)	`EarningsPerShareBasicAndDiluted`	$-1.59	USD	1 Quarter
Net loss per share - basic and diluted (in usd per share)	`EarningsPerShareBasicAndDiluted`	$-6.75	USD	Annual
Net loss per share - basic and diluted (in usd per share)	`EarningsPerShareBasicAndDiluted`	$-1.19	USD	1 Quarter
Net loss per share - basic and diluted (in usd per share)	`EarningsPerShareBasicAndDiluted`	$-1.63	USD	1 Quarter
Net loss per share - basic and diluted (in usd per share)	`EarningsPerShareBasicAndDiluted`	$-1.78	USD	1 Quarter
Net loss per share - basic and diluted (in usd per share)	`EarningsPerShareBasicAndDiluted`	$-5.07	USD	Annual
Weighted-average number of common shares used in computing net loss per share - basic and diluted (in shares)	`WeightedAverageNumberOfShareOutstandingBasicAndDiluted`	39.13M	shares	Annual
Weighted-average number of common shares used in computing net loss per share - basic and diluted (in shares)	`WeightedAverageNumberOfShareOutstandingBasicAndDiluted`	46.59M	shares	Annual
Weighted-average number of common shares used in computing net loss per share - basic and diluted (in shares)	`WeightedAverageNumberOfShareOutstandingBasicAndDiluted`	57.42M	shares	Annual

Cash Flow Statement 93 line items

Line Item	Tag	Value	Unit	Period
Net loss	`NetIncomeLoss`	$-314.67M	USD	Annual
Net loss	`NetIncomeLoss`	$-198.47M	USD	Annual
Net loss	`NetIncomeLoss`	$-346.03M	USD	Annual
Depreciation	`Depreciation`	$6.43M	USD	Annual
Depreciation	`Depreciation`	$7.17M	USD	Annual
Depreciation	`Depreciation`	$5.71M	USD	Annual
Stock-based compensation expense	`ShareBasedCompensation`	$47.81M	USD	Annual
Stock-based compensation expense	`ShareBasedCompensation`	$73.36M	USD	Annual
Stock-based compensation expense	`ShareBasedCompensation`	$42.09M	USD	Annual
Net (accretion of discount) amortization of premium on marketable securities	`AccretionAmortizationOfDiscountsAndPremiumsInvestments`	$11.00K	USD	Annual
Net (accretion of discount) amortization of premium on marketable securities	`AccretionAmortizationOfDiscountsAndPremiumsInvestments`	$-773.00K	USD	Annual
Net (accretion of discount) amortization of premium on marketable securities	`AccretionAmortizationOfDiscountsAndPremiumsInvestments`	$3.84M	USD	Annual
Loss on disposal of property and equipment	`GainLossOnDispositionOfAssets1`	$-20.00K	USD	Annual
Loss on disposal of property and equipment	`GainLossOnDispositionOfAssets1`	-	USD	Annual
Loss on disposal of property and equipment	`GainLossOnDispositionOfAssets1`	$-40.00K	USD	Annual
Accounts receivable, net	`IncreaseDecreaseInContractWithCustomerAsset`	-	USD	Annual
Accounts receivable, net	`IncreaseDecreaseInContractWithCustomerAsset`	-	USD	Annual
Accounts receivable, net	`IncreaseDecreaseInContractWithCustomerAsset`	$5.08M	USD	Annual
Collaboration receivable related party	`IncreaseDecreaseinCollaborationReceivableDuefromRelatedPartiesCurrent`	$-3.34M	USD	Annual
Collaboration receivable related party	`IncreaseDecreaseinCollaborationReceivableDuefromRelatedPartiesCurrent`	$-2.44M	USD	Annual
Collaboration receivable related party	`IncreaseDecreaseinCollaborationReceivableDuefromRelatedPartiesCurrent`	$14.00K	USD	Annual
Collaboration receivable other	`IncreaseDecreaseInCollaborationReceivableOtherCurrent`	-	USD	Annual
Collaboration receivable other	`IncreaseDecreaseInCollaborationReceivableOtherCurrent`	$670.00K	USD	Annual
Collaboration receivable other	`IncreaseDecreaseInCollaborationReceivableOtherCurrent`	-	USD	Annual
Royalty receivable related party	`IncreaseDecreaseinRoyaltyReceivableDuefromRelatedPartiesCurrent`	-	USD	Annual
Royalty receivable related party	`IncreaseDecreaseinRoyaltyReceivableDuefromRelatedPartiesCurrent`	$1.01M	USD	Annual
Royalty receivable related party	`IncreaseDecreaseinRoyaltyReceivableDuefromRelatedPartiesCurrent`	$1.22M	USD	Annual
Inventory	`IncreaseDecreaseInInventories`	-	USD	Annual
Inventory	`IncreaseDecreaseInInventories`	$869.00K	USD	Annual
Inventory	`IncreaseDecreaseInInventories`	-	USD	Annual
Prepaid expenses and other current and non-current assets	`IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets`	$2.42M	USD	Annual
Prepaid expenses and other current and non-current assets	`IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets`	$3.60M	USD	Annual
Prepaid expenses and other current and non-current assets	`IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets`	$-1.15M	USD	Annual
Accounts payable	`IncreaseDecreaseInAccountsPayable`	$-5.49M	USD	Annual
Accounts payable	`IncreaseDecreaseInAccountsPayable`	$3.50M	USD	Annual
Accounts payable	`IncreaseDecreaseInAccountsPayable`	$5.33M	USD	Annual
Accrued expenses	`IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities`	$8.62M	USD	Annual
Accrued expenses	`IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities`	$16.85M	USD	Annual
Accrued expenses	`IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities`	$1.52M	USD	Annual
Deferred revenue related party	`IncreaseDecreaseInContractWithCustomerLiabilityRelatedParty`	$-31.66M	USD	Annual
Deferred revenue related party	`IncreaseDecreaseInContractWithCustomerLiabilityRelatedParty`	$165.85M	USD	Annual
Deferred revenue related party	`IncreaseDecreaseInContractWithCustomerLiabilityRelatedParty`	$-26.57M	USD	Annual
Deferred rent	`IncreaseDecreaseInDeferredCharges`	$82.00K	USD	Annual
Deferred rent	`IncreaseDecreaseInDeferredCharges`	$2.73M	USD	Annual
Deferred rent	`IncreaseDecreaseInDeferredCharges`	$-1.35M	USD	Annual
Net cash (used in) provided by operating activities	`NetCashProvidedByUsedInOperatingActivities`	$-285.23M	USD	Annual
Net cash (used in) provided by operating activities	`NetCashProvidedByUsedInOperatingActivities`	$-304.42M	USD	Annual
Net cash (used in) provided by operating activities	`NetCashProvidedByUsedInOperatingActivities`	$38.56M	USD	Annual
Purchases of marketable securities	`PaymentsToAcquireAvailableForSaleSecurities`	$506.07M	USD	Annual
Purchases of marketable securities	`PaymentsToAcquireAvailableForSaleSecurities`	$933.32M	USD	Annual
Purchases of marketable securities	`PaymentsToAcquireAvailableForSaleSecurities`	$688.70M	USD	Annual
Proceeds from maturities and sales of marketable securities	`ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities`	$666.48M	USD	Annual
Proceeds from maturities and sales of marketable securities	`ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities`	$396.63M	USD	Annual
Proceeds from maturities and sales of marketable securities	`ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities`	$635.42M	USD	Annual
Purchases of property and equipment	`PaymentsToAcquirePropertyPlantAndEquipment`	$4.63M	USD	Annual
Purchases of property and equipment	`PaymentsToAcquirePropertyPlantAndEquipment`	$6.99M	USD	Annual
Purchases of property and equipment	`PaymentsToAcquirePropertyPlantAndEquipment`	$9.91M	USD	Annual
Net cash used in investing activities	`NetCashProvidedByUsedInInvestingActivities`	$-57.91M	USD	Annual
Net cash used in investing activities	`NetCashProvidedByUsedInInvestingActivities`	$-273.82M	USD	Annual
Net cash used in investing activities	`NetCashProvidedByUsedInInvestingActivities`	$-119.35M	USD	Annual
Proceeds from public offering of common stock, net of reimbursements	`ProceedsFromIssuanceOfCommonStock`	$270.25M	USD	Annual
Proceeds from public offering of common stock, net of reimbursements	`ProceedsFromIssuanceOfCommonStock`	$516.21M	USD	Annual
Proceeds from public offering of common stock, net of reimbursements	`ProceedsFromIssuanceOfCommonStock`	$516.20M	USD	Point-in-time
Proceeds from public offering of common stock, net of reimbursements	`ProceedsFromIssuanceOfCommonStock`	$162.15M	USD	Annual
(Payment) of public offering costs	`PaymentsOfStockIssuanceCosts`	$391.00K	USD	Annual
(Payment) of public offering costs	`PaymentsOfStockIssuanceCosts`	$230.00K	USD	Annual
Reiumbursement of public offering costs	`ReiumbursementOfStockIssuanceCosts`	$638.00K	USD	Annual
Net proceeds from stock option exercises and employee stock purchase plan	`ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions`	$30.21M	USD	Annual
Net proceeds from stock option exercises and employee stock purchase plan	`ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions`	$7.86M	USD	Annual
Net proceeds from stock option exercises and employee stock purchase plan	`ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions`	$14.22M	USD	Annual
Net cash provided by financing activities	`NetCashProvidedByUsedInFinancingActivities`	$169.78M	USD	Annual
Net cash provided by financing activities	`NetCashProvidedByUsedInFinancingActivities`	$546.02M	USD	Annual
Net cash provided by financing activities	`NetCashProvidedByUsedInFinancingActivities`	$285.11M	USD	Annual
Net change in cash and cash equivalents	`CashAndCashEquivalentsPeriodIncreaseDecrease`	$-58.03M	USD	Annual
Net change in cash and cash equivalents	`CashAndCashEquivalentsPeriodIncreaseDecrease`	$88.99M	USD	Annual
Net change in cash and cash equivalents	`CashAndCashEquivalentsPeriodIncreaseDecrease`	$-32.22M	USD	Annual
Cash and cash equivalents at beginning of the period	`CashAndCashEquivalentsAtCarryingValue`	$71.76M	USD	Point-in-time
Cash and cash equivalents at beginning of the period	`CashAndCashEquivalentsAtCarryingValue`	$160.75M	USD	Point-in-time
Cash and cash equivalents at beginning of the period	`CashAndCashEquivalentsAtCarryingValue`	$70.50M	USD	Point-in-time
Cash and cash equivalents at beginning of the period	`CashAndCashEquivalentsAtCarryingValue`	$102.72M	USD	Point-in-time
Cash and cash equivalents at end of the period	`CashAndCashEquivalentsAtCarryingValue`	$71.76M	USD	Point-in-time
Cash and cash equivalents at end of the period	`CashAndCashEquivalentsAtCarryingValue`	$160.75M	USD	Point-in-time
Cash and cash equivalents at end of the period	`CashAndCashEquivalentsAtCarryingValue`	$70.50M	USD	Point-in-time
Cash and cash equivalents at end of the period	`CashAndCashEquivalentsAtCarryingValue`	$102.72M	USD	Point-in-time
Additions to property and equipment in accounts payable and accrued expenses	`CapitalExpendituresIncurredButNotYetPaid`	$73.00K	USD	Annual
Additions to property and equipment in accounts payable and accrued expenses	`CapitalExpendituresIncurredButNotYetPaid`	$1.01M	USD	Annual
Additions to property and equipment in accounts payable and accrued expenses	`CapitalExpendituresIncurredButNotYetPaid`	$1.11M	USD	Annual
Proceeds from stock option exercises in other current assets	`ProceedsFromStockOptionsExercisedInOtherCurrentAssets`	$32.00K	USD	Annual
Proceeds from stock option exercises in other current assets	`ProceedsFromStockOptionsExercisedInOtherCurrentAssets`	-	USD	Annual
Proceeds from stock option exercises in other current assets	`ProceedsFromStockOptionsExercisedInOtherCurrentAssets`	$7.00K	USD	Annual
Public offering costs in other receivables, net of amounts in accounts payable and accrued expenses	`PublicOfferingCostsInOtherCurrentAssets`	-	USD	Annual
Public offering costs in other receivables, net of amounts in accounts payable and accrued expenses	`PublicOfferingCostsInOtherCurrentAssets`	-	USD	Annual
Public offering costs in other receivables, net of amounts in accounts payable and accrued expenses	`PublicOfferingCostsInOtherCurrentAssets`	$230.00K	USD	Annual

Stockholders Equity 27 line items

Line Item	Tag	Value	Unit	Period
Beginning balance	`StockholdersEquity`	$687.54M	USD	Point-in-time
Beginning balance	`StockholdersEquity`	$358.59M	USD	Point-in-time
Beginning balance	`StockholdersEquity`	$375.50M	USD	Point-in-time
Beginning balance	`StockholdersEquity`	$345.12M	USD	Point-in-time
Unrealized gain (loss) on available-for-sale securities	`OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax`	$-782.00K	USD	Annual
Unrealized gain (loss) on available-for-sale securities	`OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax`	$-1.08M	USD	Annual
Unrealized gain (loss) on available-for-sale securities	`OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax`	$5.00K	USD	Annual
Net loss	`NetIncomeLoss`	$-314.67M	USD	Annual
Net loss	`NetIncomeLoss`	$-198.47M	USD	Annual
Net loss	`NetIncomeLoss`	$-346.03M	USD	Annual
Stock-based compensation expense	`AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue`	$73.36M	USD	Annual
Stock-based compensation expense	`AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue`	$47.81M	USD	Annual
Stock-based compensation expense	`AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue`	$42.09M	USD	Annual
Issuance of common stock under stock incentive and employee stock purchase plan (in shares)	`StockIssuedDuringPeriodSharesStockOptionsExercised`	1.13M	shares	Annual
Issuance of common stock under stock incentive and employee stock purchase plan	`StockIssuedDuringPeriodValueStockOptionsExercised`	$7.70M	USD	Annual
Issuance of common stock under stock incentive and employee stock purchase plan	`StockIssuedDuringPeriodValueStockOptionsExercised`	$30.22M	USD	Annual
Issuance of common stock under stock incentive and employee stock purchase plan	`StockIssuedDuringPeriodValueStockOptionsExercised`	$14.19M	USD	Annual
Issuance of common stock for follow-on offering (in shares)	`StockIssuedDuringPeriodSharesNewIssues`	8.15M	shares	Point-in-time
Issuance of common stock for follow-on offering	`StockIssuedDuringPeriodValueNewIssues`	$270.25M	USD	Annual
Issuance of common stock for follow-on offering	`StockIssuedDuringPeriodValueNewIssues`	$516.21M	USD	Annual
Issuance of common stock for follow-on offering	`StockIssuedDuringPeriodValueNewIssues`	$162.15M	USD	Annual
Other	`StockholdersEquityOther`	$-391.00K	USD	Annual
Other	`StockholdersEquityOther`	$409.00K	USD	Annual
Ending balance	`StockholdersEquity`	$687.54M	USD	Point-in-time
Ending balance	`StockholdersEquity`	$358.59M	USD	Point-in-time
Ending balance	`StockholdersEquity`	$375.50M	USD	Point-in-time
Ending balance	`StockholdersEquity`	$345.12M	USD	Point-in-time

Comprehensive Income 9 line items

Line Item	Tag	Value	Unit	Period
Net loss	`NetIncomeLoss`	$-314.67M	USD	Annual
Net loss	`NetIncomeLoss`	$-198.47M	USD	Annual
Net loss	`NetIncomeLoss`	$-346.03M	USD	Annual
Unrealized (loss) gain on available-for-sale securities	`OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax`	$-782.00K	USD	Annual
Unrealized (loss) gain on available-for-sale securities	`OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax`	$-1.08M	USD	Annual
Unrealized (loss) gain on available-for-sale securities	`OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax`	$5.00K	USD	Annual
Comprehensive loss	`ComprehensiveIncomeNetOfTax`	$-315.75M	USD	Annual
Comprehensive loss	`ComprehensiveIncomeNetOfTax`	$-346.81M	USD	Annual
Comprehensive loss	`ComprehensiveIncomeNetOfTax`	$-198.47M	USD	Annual

Data is extracted from SEC EDGAR XBRL filings. Values shown are as reported in the filing.