10-K Filing

AGIOS PHARMACEUTICALS, INC. CIK: 1439222 FY 2020

Filing Information

Form Type	10-K
Accession Number	`0001439222-21-000029`
Period End Date	20201231
Filing Date	20210225
Fiscal Year	2020
Fiscal Period	FY
XBRL Instance	agio-20201231_htm.xml

Filing Contents

This filing contains the following financial statements:

Balance Sheet 98 Income Statement 57 Cash Flow Statement 109 Stockholders Equity 25 Comprehensive Income 9

Balance Sheet 98 line items

Line Item	Tag	Value	Unit	Period
Preferred stock, par value (in usd per share)	`PreferredStockParOrStatedValuePerShare`	$0.00	USD	Point-in-time
Preferred stock, par value (in usd per share)	`PreferredStockParOrStatedValuePerShare`	$0.00	USD	Point-in-time
Preferred stock, shares authorized (in shares)	`PreferredStockSharesAuthorized`	25.00M	shares	Point-in-time
Preferred stock, shares authorized (in shares)	`PreferredStockSharesAuthorized`	25.00M	shares	Point-in-time
Preferred stock, shares issued (in shares)	`PreferredStockSharesIssued`	0.00	shares	Point-in-time
Preferred stock, shares issued (in shares)	`PreferredStockSharesIssued`	0.00	shares	Point-in-time
Cash and cash equivalents	`CashAndCashEquivalentsAtCarryingValue`	$127.44M	USD	Point-in-time
Cash and cash equivalents	`CashAndCashEquivalentsAtCarryingValue`	$80.93M	USD	Point-in-time
Marketable securities	`AvailableForSaleSecuritiesDebtSecuritiesCurrent`	$483.95M	USD	Point-in-time
Marketable securities	`AvailableForSaleSecuritiesDebtSecuritiesCurrent`	$445.49M	USD	Point-in-time
Preferred stock, shares outstanding (in shares)	`PreferredStockSharesOutstanding`	0.00	shares	Point-in-time
Preferred stock, shares outstanding (in shares)	`PreferredStockSharesOutstanding`	0.00	shares	Point-in-time
Accounts receivable, net	`ContractWithCustomerAssetNetCurrent`	$5.08M	USD	Point-in-time
Accounts receivable, net	`ContractWithCustomerAssetNetCurrent`	$8.95M	USD	Point-in-time
Common stock, par value (in usd per share)	`CommonStockParOrStatedValuePerShare`	$0.00	USD	Point-in-time
Common stock, par value (in usd per share)	`CommonStockParOrStatedValuePerShare`	$0.00	USD	Point-in-time
Accounts receivable, net	`ContractWithCustomerAssetNetCurrent`	$21.33M	USD	Point-in-time
Collaboration receivable related party	`CollaborationReceivableDuefromRelatedPartiesCurrent`	$2.46M	USD	Point-in-time
Common stock, shares authorized (in shares)	`CommonStockSharesAuthorized`	125.00M	shares	Point-in-time
Common stock, shares authorized (in shares)	`CommonStockSharesAuthorized`	125.00M	shares	Point-in-time
Collaboration receivable related party	`CollaborationReceivableDuefromRelatedPartiesCurrent`	$2.12M	USD	Point-in-time
Collaboration receivable related party	`CollaborationReceivableDuefromRelatedPartiesCurrent`	$1.54M	USD	Point-in-time
Common stock, shares issued (in shares)	`CommonStockSharesIssued`	69.29M	shares	Point-in-time
Common stock, shares issued (in shares)	`CommonStockSharesIssued`	68.40M	shares	Point-in-time
Collaboration receivable other	`CollaborationReceivableOtherCurrent`	$1.95M	USD	Point-in-time
Collaboration receivable other	`CollaborationReceivableOtherCurrent`	$1.93M	USD	Point-in-time
Collaboration receivable other	`CollaborationReceivableOtherCurrent`	$670.00K	USD	Point-in-time
Royalty receivable related party	`RoyaltyReceivableDuefromRelatedPartiesCurrent`	-	USD	Point-in-time
Common stock, shares outstanding (in shares)	`CommonStockSharesOutstanding`	69.29M	shares	Point-in-time
Royalty receivable related party	`RoyaltyReceivableDuefromRelatedPartiesCurrent`	$2.90M	USD	Point-in-time
Common stock, shares outstanding (in shares)	`CommonStockSharesOutstanding`	68.40M	shares	Point-in-time
Inventory	`InventoryNet`	$14.70M	USD	Point-in-time
Inventory	`InventoryNet`	$7.33M	USD	Point-in-time
Prepaid expenses and other current assets	`PrepaidExpenseAndOtherAssetsCurrent`	$24.18M	USD	Point-in-time
Prepaid expenses and other current assets	`PrepaidExpenseAndOtherAssetsCurrent`	$23.65M	USD	Point-in-time
Total current assets	`AssetsCurrent`	$613.78M	USD	Point-in-time
Total current assets	`AssetsCurrent`	$611.70M	USD	Point-in-time
Total current assets	`AssetsCurrent`	$636.68M	USD	Point-in-time
Marketable securities	`AvailableForSaleSecuritiesDebtSecuritiesNoncurrent`	$152.93M	USD	Point-in-time
Marketable securities	`AvailableForSaleSecuritiesDebtSecuritiesNoncurrent`	$97.61M	USD	Point-in-time
Operating lease assets	`OperatingLeaseRightOfUseAsset`	$84.66M	USD	Point-in-time
Operating lease assets	`OperatingLeaseRightOfUseAsset`	$93.64M	USD	Point-in-time
Property and equipment, net	`PropertyPlantAndEquipmentNet`	$31.47M	USD	Point-in-time
Property and equipment, net	`PropertyPlantAndEquipmentNet`	$32.29M	USD	Point-in-time
Financing lease assets	`FinanceLeaseRightOfUseAsset`	$993.00K	USD	Point-in-time
Financing lease assets	`FinanceLeaseRightOfUseAsset`	$590.00K	USD	Point-in-time
Other non-current assets	`OtherAssetsNoncurrent`	-	USD	Point-in-time
Other non-current assets	`OtherAssetsNoncurrent`	$1.12M	USD	Point-in-time
Total assets	`Assets`	$890.74M	USD	Point-in-time
Total assets	`Assets`	$852.95M	USD	Point-in-time
Total assets	`Assets`	$858.46M	USD	Point-in-time
Accounts payable	`AccountsPayableCurrent`	$26.84M	USD	Point-in-time
Accounts payable	`AccountsPayableCurrent`	$21.90M	USD	Point-in-time
Accrued expenses	`AccruedLiabilitiesCurrent`	$60.14M	USD	Point-in-time
Accrued expenses	`AccruedLiabilitiesCurrent`	$53.14M	USD	Point-in-time
Deferred revenue related party	`ContractWithCustomerLiabilityCurrent`	-	USD	Point-in-time
Deferred revenue related party	`ContractWithCustomerLiabilityCurrent`	$10.93M	USD	Point-in-time
Deferred revenue related party	`ContractWithCustomerLiabilityCurrent`	$32.71M	USD	Point-in-time
Operating lease liabilities	`OperatingLeaseLiabilityCurrent`	$6.64M	USD	Point-in-time
Operating lease liabilities	`OperatingLeaseLiabilityCurrent`	$7.09M	USD	Point-in-time
Financing lease liabilities	`FinanceLeaseLiabilityCurrent`	$317.00K	USD	Point-in-time
Financing lease liabilities	`FinanceLeaseLiabilityCurrent`	$273.00K	USD	Point-in-time
Total current liabilities	`LiabilitiesCurrent`	$92.89M	USD	Point-in-time
Total current liabilities	`LiabilitiesCurrent`	$93.50M	USD	Point-in-time
Total current liabilities	`LiabilitiesCurrent`	$94.39M	USD	Point-in-time
Deferred revenue, net of current portion related party	`ContractWithCustomerLiabilityNoncurrent`	$50.58M	USD	Point-in-time
Deferred revenue, net of current portion related party	`ContractWithCustomerLiabilityNoncurrent`	$59.81M	USD	Point-in-time
Deferred revenue, net of current portion related party	`ContractWithCustomerLiabilityNoncurrent`	-	USD	Point-in-time
Operating lease liabilities, net of current portion	`OperatingLeaseLiabilityNoncurrent`	$106.07M	USD	Point-in-time
Operating lease liabilities, net of current portion	`OperatingLeaseLiabilityNoncurrent`	$97.46M	USD	Point-in-time
Financing lease liabilities, net of current portion	`FinanceLeaseLiabilityNoncurrent`	$331.00K	USD	Point-in-time
Financing lease liabilities, net of current portion	`FinanceLeaseLiabilityNoncurrent`	$673.00K	USD	Point-in-time
Liability related to the sale of future revenue, net of debt issuance costs	`SaleOfFutureRevenueLiabilityNoncurrent`	-	USD	Point-in-time
Liability related to the sale of future revenue, net of debt issuance costs	`SaleOfFutureRevenueLiabilityNoncurrent`	$261.27M	USD	Point-in-time
Total liabilities	`Liabilities`	$170.92M	USD	Point-in-time
Total liabilities	`Liabilities`	$250.21M	USD	Point-in-time
Total liabilities	`Liabilities`	$453.45M	USD	Point-in-time
Commitments and contingent liabilities (Note 11)	`CommitmentsAndContingencies`	-	USD	Point-in-time
Commitments and contingent liabilities (Note 11)	`CommitmentsAndContingencies`	-	USD	Point-in-time
Preferred stock, $0.001 par value; 25,000,000 shares authorized, no shares issued and outstanding at December 31, 2020 and 2019	`PreferredStockValue`	-	USD	Point-in-time
Preferred stock, $0.001 par value; 25,000,000 shares authorized, no shares issued and outstanding at December 31, 2020 and 2019	`PreferredStockValue`	-	USD	Point-in-time
Common stock, $0.001 par value; 125,000,000 shares authorized and 69,293,920 and 68,401,105 shares issued and outstanding at December 31, 2020 and 2019, respectively	`CommonStockValue`	$68.00K	USD	Point-in-time
Common stock, $0.001 par value; 125,000,000 shares authorized and 69,293,920 and 68,401,105 shares issued and outstanding at December 31, 2020 and 2019, respectively	`CommonStockValue`	$69.00K	USD	Point-in-time
Additional paid-in capital	`AdditionalPaidInCapitalCommonStock`	$2.16B	USD	Point-in-time
Additional paid-in capital	`AdditionalPaidInCapitalCommonStock`	$2.24B	USD	Point-in-time
Accumulated other comprehensive income	`AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax`	$202.00K	USD	Point-in-time
Accumulated other comprehensive income	`AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax`	$105.00K	USD	Point-in-time
Accumulated deficit	`RetainedEarningsAccumulatedDeficit`	$-1.10B	USD	Point-in-time
Accumulated deficit	`RetainedEarningsAccumulatedDeficit`	$-1.84B	USD	Point-in-time
Accumulated deficit	`RetainedEarningsAccumulatedDeficit`	$-758.61M	USD	Point-in-time
Accumulated deficit	`RetainedEarningsAccumulatedDeficit`	$-1.52B	USD	Point-in-time
Total stockholders equity	`StockholdersEquity`	$640.53M	USD	Point-in-time
Total stockholders equity	`StockholdersEquity`	$375.50M	USD	Point-in-time
Total stockholders equity	`StockholdersEquity`	$399.50M	USD	Point-in-time
Total stockholders equity	`StockholdersEquity`	$687.54M	USD	Point-in-time
Total liabilities and stockholders equity	`LiabilitiesAndStockholdersEquity`	$858.46M	USD	Point-in-time
Total liabilities and stockholders equity	`LiabilitiesAndStockholdersEquity`	$852.95M	USD	Point-in-time
Total liabilities and stockholders equity	`LiabilitiesAndStockholdersEquity`	$890.74M	USD	Point-in-time

Income Statement 57 line items

Line Item	Tag	Value	Unit	Period
Revenues	`RevenueFromContractWithCustomerExcludingAssessedTax`	$34.71M	USD	1 Quarter
Revenues	`RevenueFromContractWithCustomerExcludingAssessedTax`	$26.02M	USD	1 Quarter
Revenues	`RevenueFromContractWithCustomerExcludingAssessedTax`	$117.91M	USD	Annual
Revenues	`RevenueFromContractWithCustomerExcludingAssessedTax`	$94.39M	USD	Annual
Revenues	`RevenueFromContractWithCustomerExcludingAssessedTax`	$203.20M	USD	Annual
Revenues	`RevenueFromContractWithCustomerExcludingAssessedTax`	$35.44M	USD	1 Quarter
Revenues	`RevenueFromContractWithCustomerExcludingAssessedTax`	$37.35M	USD	1 Quarter
Revenues	`RevenueFromContractWithCustomerExcludingAssessedTax`	$26.22M	USD	1 Quarter
Revenues	`RevenueFromContractWithCustomerExcludingAssessedTax`	$87.10M	USD	1 Quarter
Revenues	`RevenueFromContractWithCustomerExcludingAssessedTax`	$30.23M	USD	1 Quarter
Revenues	`RevenueFromContractWithCustomerExcludingAssessedTax`	$44.05M	USD	1 Quarter
Cost of sales	`CostOfGoodsAndServicesSold`	$2.81M	USD	Annual
Cost of sales	`CostOfGoodsAndServicesSold`	$1.32M	USD	Annual
Cost of sales	`CostOfGoodsAndServicesSold`	$1.40M	USD	Annual
Research and development	`ResearchAndDevelopmentExpense`	$410.89M	USD	Annual
Research and development	`ResearchAndDevelopmentExpense`	$367.47M	USD	Annual
Research and development	`ResearchAndDevelopmentExpense`	$341.32M	USD	Annual
Selling, general and administrative	`SellingGeneralAndAdministrativeExpense`	$149.07M	USD	Annual
Selling, general and administrative	`SellingGeneralAndAdministrativeExpense`	$114.14M	USD	Annual
Selling, general and administrative	`SellingGeneralAndAdministrativeExpense`	$132.03M	USD	Annual
Total cost and expenses	`CostsAndExpenses`	$456.87M	USD	Annual
Total cost and expenses	`CostsAndExpenses`	$544.25M	USD	Annual
Total cost and expenses	`CostsAndExpenses`	$519.35M	USD	Annual
Loss from operations	`OperatingIncomeLoss`	$-97.48M	USD	1 Quarter
Loss from operations	`OperatingIncomeLoss`	$-426.33M	USD	Annual
Loss from operations	`OperatingIncomeLoss`	$-90.20M	USD	1 Quarter
Loss from operations	`OperatingIncomeLoss`	$-92.43M	USD	1 Quarter
Loss from operations	`OperatingIncomeLoss`	$-316.15M	USD	Annual
Loss from operations	`OperatingIncomeLoss`	$-105.93M	USD	1 Quarter
Loss from operations	`OperatingIncomeLoss`	$-362.48M	USD	Annual
Loss from operations	`OperatingIncomeLoss`	$-90.33M	USD	1 Quarter
Loss from operations	`OperatingIncomeLoss`	$-113.86M	USD	1 Quarter
Loss from operations	`OperatingIncomeLoss`	$-43.19M	USD	1 Quarter
Loss from operations	`OperatingIncomeLoss`	$-109.06M	USD	1 Quarter
Interest income, net	`InvestmentIncomeInterest`	$14.86M	USD	Annual
Interest income, net	`InvestmentIncomeInterest`	$6.61M	USD	Annual
Interest income, net	`InvestmentIncomeInterest`	$16.45M	USD	Annual
Non-cash interest expense for the sale of future revenue	`InterestExpenseNonCashSaleOfFutureRevenue`	-	USD	Annual
Non-cash interest expense for the sale of future revenue	`InterestExpenseNonCashSaleOfFutureRevenue`	-	USD	Annual
Non-cash interest expense for the sale of future revenue	`InterestExpenseNonCashSaleOfFutureRevenue`	$17.83M	USD	Annual
Net loss	`NetIncomeLoss`	$-411.47M	USD	Annual
Net loss	`NetIncomeLoss`	$-346.03M	USD	Annual
Net loss	`NetIncomeLoss`	$-327.37M	USD	Annual
Net loss per share - basic and diluted (in usd per share)	`EarningsPerShareBasicAndDiluted`	$-6.86	USD	Annual
Net loss per share - basic and diluted (in usd per share)	`EarningsPerShareBasicAndDiluted`	$-4.74	USD	Annual
Net loss per share - basic and diluted (in usd per share)	`EarningsPerShareBasicAndDiluted`	$-1.43	USD	1 Quarter
Net loss per share - basic and diluted (in usd per share)	`EarningsPerShareBasicAndDiluted`	$-1.41	USD	1 Quarter
Net loss per share - basic and diluted (in usd per share)	`EarningsPerShareBasicAndDiluted`	$-1.81	USD	1 Quarter
Net loss per share - basic and diluted (in usd per share)	`EarningsPerShareBasicAndDiluted`	$-1.87	USD	1 Quarter
Net loss per share - basic and diluted (in usd per share)	`EarningsPerShareBasicAndDiluted`	$-1.60	USD	1 Quarter
Net loss per share - basic and diluted (in usd per share)	`EarningsPerShareBasicAndDiluted`	$-1.59	USD	1 Quarter
Net loss per share - basic and diluted (in usd per share)	`EarningsPerShareBasicAndDiluted`	$-1.31	USD	1 Quarter
Net loss per share - basic and diluted (in usd per share)	`EarningsPerShareBasicAndDiluted`	$-0.59	USD	1 Quarter
Net loss per share - basic and diluted (in usd per share)	`EarningsPerShareBasicAndDiluted`	$-6.03	USD	Annual
Weighted-average number of common shares used in computing net loss per share - basic and diluted (in shares)	`WeightedAverageNumberOfShareOutstandingBasicAndDiluted`	59.99M	shares	Annual
Weighted-average number of common shares used in computing net loss per share - basic and diluted (in shares)	`WeightedAverageNumberOfShareOutstandingBasicAndDiluted`	57.42M	shares	Annual
Weighted-average number of common shares used in computing net loss per share - basic and diluted (in shares)	`WeightedAverageNumberOfShareOutstandingBasicAndDiluted`	69.00M	shares	Annual

Cash Flow Statement 109 line items

Line Item	Tag	Value	Unit	Period
Net loss	`NetIncomeLoss`	$-411.47M	USD	Annual
Net loss	`NetIncomeLoss`	$-346.03M	USD	Annual
Net loss	`NetIncomeLoss`	$-327.37M	USD	Annual
Depreciation and amortization	`OtherDepreciationAndAmortization`	$7.17M	USD	Annual
Depreciation and amortization	`OtherDepreciationAndAmortization`	$9.98M	USD	Annual
Depreciation and amortization	`OtherDepreciationAndAmortization`	$8.09M	USD	Annual
Stock-based compensation expense	`ShareBasedCompensation`	$75.12M	USD	Annual
Stock-based compensation expense	`ShareBasedCompensation`	$72.37M	USD	Annual
Stock-based compensation expense	`ShareBasedCompensation`	$73.36M	USD	Annual
Net amortization of premium (accretion of discount) on marketable securities	`AccretionAmortizationOfDiscountsAndPremiumsInvestments`	$3.84M	USD	Annual
Net amortization of premium (accretion of discount) on marketable securities	`AccretionAmortizationOfDiscountsAndPremiumsInvestments`	$-3.02M	USD	Annual
Net amortization of premium (accretion of discount) on marketable securities	`AccretionAmortizationOfDiscountsAndPremiumsInvestments`	$3.19M	USD	Annual
Loss on disposal of property and equipment	`GainLossOnSaleOfPropertyPlantEquipment`	$-20.00K	USD	Annual
Loss on disposal of property and equipment	`GainLossOnSaleOfPropertyPlantEquipment`	-	USD	Annual
Loss on disposal of property and equipment	`GainLossOnSaleOfPropertyPlantEquipment`	$-1.05M	USD	Annual
Non-cash operating lease expense	`OperatingLeaseRightOfUseAssetAmortizationExpense`	$8.98M	USD	Annual
Non-cash operating lease expense	`OperatingLeaseRightOfUseAssetAmortizationExpense`	$8.53M	USD	Annual
Non-cash interest expense associated with the sale of future revenue	`InterestExpenseNonCashSaleOfFutureRevenue`	-	USD	Annual
Non-cash interest expense associated with the sale of future revenue	`InterestExpenseNonCashSaleOfFutureRevenue`	-	USD	Annual
Non-cash interest expense associated with the sale of future revenue	`InterestExpenseNonCashSaleOfFutureRevenue`	$17.83M	USD	Annual
Non-cash royalty revenue	`RoyaltyRevenueNonCash`	-	USD	Annual
Non-cash royalty revenue	`RoyaltyRevenueNonCash`	$7.29M	USD	Annual
Non-cash royalty revenue	`RoyaltyRevenueNonCash`	-	USD	Annual
Accounts receivable, net	`IncreaseDecreaseInContractWithCustomerAsset`	$3.88M	USD	Annual
Accounts receivable, net	`IncreaseDecreaseInContractWithCustomerAsset`	$5.08M	USD	Annual
Accounts receivable, net	`IncreaseDecreaseInContractWithCustomerAsset`	$12.38M	USD	Annual
Collaboration receivable related party	`IncreaseDecreaseinCollaborationReceivableDuefromRelatedPartiesCurrent`	$14.00K	USD	Annual
Collaboration receivable related party	`IncreaseDecreaseinCollaborationReceivableDuefromRelatedPartiesCurrent`	$-923.00K	USD	Annual
Collaboration receivable related party	`IncreaseDecreaseinCollaborationReceivableDuefromRelatedPartiesCurrent`	$584.00K	USD	Annual
Collaboration receivable other	`IncreaseDecreaseInCollaborationReceivableOtherCurrent`	$670.00K	USD	Annual
Collaboration receivable other	`IncreaseDecreaseInCollaborationReceivableOtherCurrent`	$1.26M	USD	Annual
Collaboration receivable other	`IncreaseDecreaseInCollaborationReceivableOtherCurrent`	$20.00K	USD	Annual
Royalty receivable related party	`IncreaseDecreaseinRoyaltyReceivableDuefromRelatedPartiesCurrent`	$-2.90M	USD	Annual
Royalty receivable related party	`IncreaseDecreaseinRoyaltyReceivableDuefromRelatedPartiesCurrent`	$666.00K	USD	Annual
Royalty receivable related party	`IncreaseDecreaseinRoyaltyReceivableDuefromRelatedPartiesCurrent`	$1.01M	USD	Annual
Inventory	`IncreaseDecreaseInInventories`	$6.46M	USD	Annual
Inventory	`IncreaseDecreaseInInventories`	$869.00K	USD	Annual
Inventory	`IncreaseDecreaseInInventories`	$7.37M	USD	Annual
Prepaid expenses and other current and non-current assets	`IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets`	$7.74M	USD	Annual
Prepaid expenses and other current and non-current assets	`IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets`	$599.00K	USD	Annual
Prepaid expenses and other current and non-current assets	`IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets`	$-1.15M	USD	Annual
Accounts payable	`IncreaseDecreaseInAccountsPayable`	$-5.49M	USD	Annual
Accounts payable	`IncreaseDecreaseInAccountsPayable`	$3.72M	USD	Annual
Accounts payable	`IncreaseDecreaseInAccountsPayable`	$5.89M	USD	Annual
Accrued expenses	`IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities`	$10.76M	USD	Annual
Accrued expenses	`IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities`	$8.62M	USD	Annual
Accrued expenses	`IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities`	$7.23M	USD	Annual
Deferred revenue related party	`IncreaseDecreaseInContractWithCustomerLiabilityRelatedParty`	$-31.66M	USD	Annual
Deferred revenue related party	`IncreaseDecreaseInContractWithCustomerLiabilityRelatedParty`	$-61.51M	USD	Annual
Deferred revenue related party	`IncreaseDecreaseInContractWithCustomerLiabilityRelatedParty`	$-31.01M	USD	Annual
Operating lease liabilities	`IncreaseDecreaseInOperatingLeaseLiability`	$-6.86M	USD	Annual
Operating lease liabilities	`IncreaseDecreaseInOperatingLeaseLiability`	$-8.13M	USD	Annual
Deferred rent	`IncreaseDecreaseInDeferredCharges`	$82.00K	USD	Annual
Deferred rent	`IncreaseDecreaseInDeferredCharges`	-	USD	Annual
Deferred rent	`IncreaseDecreaseInDeferredCharges`	-	USD	Annual
Net cash used in operating activities	`NetCashProvidedByUsedInOperatingActivities`	$-304.42M	USD	Annual
Net cash used in operating activities	`NetCashProvidedByUsedInOperatingActivities`	$-370.62M	USD	Annual
Net cash used in operating activities	`NetCashProvidedByUsedInOperatingActivities`	$-290.76M	USD	Annual
Purchases of marketable securities	`PaymentsToAcquireAvailableForSaleSecuritiesDebt`	$933.32M	USD	Annual
Purchases of marketable securities	`PaymentsToAcquireAvailableForSaleSecuritiesDebt`	$488.57M	USD	Annual
Purchases of marketable securities	`PaymentsToAcquireAvailableForSaleSecuritiesDebt`	$557.03M	USD	Annual
Proceeds from maturities and sales of marketable securities	`ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities`	$592.18M	USD	Annual
Proceeds from maturities and sales of marketable securities	`ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities`	$647.68M	USD	Annual
Proceeds from maturities and sales of marketable securities	`ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities`	$666.48M	USD	Annual
Purchases of property and equipment	`PaymentsToAcquirePropertyPlantAndEquipment`	$12.17M	USD	Annual
Purchases of property and equipment	`PaymentsToAcquirePropertyPlantAndEquipment`	$6.99M	USD	Annual
Purchases of property and equipment	`PaymentsToAcquirePropertyPlantAndEquipment`	$14.91M	USD	Annual
Net cash provided by (used in) investing activities	`NetCashProvidedByUsedInInvestingActivities`	$75.75M	USD	Annual
Net cash provided by (used in) investing activities	`NetCashProvidedByUsedInInvestingActivities`	$-273.82M	USD	Annual
Net cash provided by (used in) investing activities	`NetCashProvidedByUsedInInvestingActivities`	$91.44M	USD	Annual
Payments on financing lease obligations	`FinanceLeasePrincipalPayments`	$113.00K	USD	Annual
Payments on financing lease obligations	`FinanceLeasePrincipalPayments`	$336.00K	USD	Annual
Proceeds from public offering of common stock, net of reimbursements	`ProceedsFromIssuanceOfCommonStock`	$516.21M	USD	Annual
Proceeds from public offering of common stock, net of reimbursements	`ProceedsFromIssuanceOfCommonStock`	-	USD	Annual
Proceeds from public offering of common stock, net of reimbursements	`ProceedsFromIssuanceOfCommonStock`	$277.20M	USD	Point-in-time
Proceeds from public offering of common stock, net of reimbursements	`ProceedsFromIssuanceOfCommonStock`	$277.20M	USD	Annual
Reimbursement (payment) of public offering costs	`PaymentsOfStockIssuanceCosts`	$391.00K	USD	Annual
Reimbursement (payment) of public offering costs	`PaymentsOfStockIssuanceCosts`	-	USD	Annual
Reimbursement (payment) of public offering costs	`PaymentsOfStockIssuanceCosts`	-	USD	Annual
Proceeds from the sale of future revenue, net of issuance costs	`ProceedsFromSaleOfFutureRevenuesNetOfIssuanceCosts`	$250.54M	USD	Annual
Proceeds from the sale of future revenue, net of issuance costs	`ProceedsFromSaleOfFutureRevenuesNetOfIssuanceCosts`	-	USD	Annual
Proceeds from the sale of future revenue, net of issuance costs	`ProceedsFromSaleOfFutureRevenuesNetOfIssuanceCosts`	-	USD	Annual
Net proceeds from stock option exercises and employee stock purchase plan	`ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions`	$12.52M	USD	Annual
Net proceeds from stock option exercises and employee stock purchase plan	`ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions`	$30.21M	USD	Annual
Net proceeds from stock option exercises and employee stock purchase plan	`ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions`	$11.32M	USD	Annual
Net cash provided by financing activities	`NetCashProvidedByUsedInFinancingActivities`	$261.52M	USD	Annual
Net cash provided by financing activities	`NetCashProvidedByUsedInFinancingActivities`	$289.61M	USD	Annual
Net cash provided by financing activities	`NetCashProvidedByUsedInFinancingActivities`	$546.02M	USD	Annual
Net change in cash and cash equivalents	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect`	$-32.22M	USD	Annual
Net change in cash and cash equivalents	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect`	$10.43M	USD	Annual
Net change in cash and cash equivalents	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect`	$46.51M	USD	Annual
Cash and cash equivalents at beginning of the period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$127.44M	USD	Point-in-time
Cash and cash equivalents at beginning of the period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$70.50M	USD	Point-in-time
Cash and cash equivalents at beginning of the period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$102.72M	USD	Point-in-time
Cash and cash equivalents at beginning of the period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$80.93M	USD	Point-in-time
Cash and cash equivalents at end of the period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$127.44M	USD	Point-in-time
Cash and cash equivalents at end of the period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$70.50M	USD	Point-in-time
Cash and cash equivalents at end of the period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$102.72M	USD	Point-in-time
Cash and cash equivalents at end of the period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$80.93M	USD	Point-in-time
Additions to property and equipment in accounts payable and accrued expenses	`CapitalExpendituresIncurredButNotYetPaid`	$5.17M	USD	Annual
Additions to property and equipment in accounts payable and accrued expenses	`CapitalExpendituresIncurredButNotYetPaid`	$465.00K	USD	Annual
Additions to property and equipment in accounts payable and accrued expenses	`CapitalExpendituresIncurredButNotYetPaid`	$1.11M	USD	Annual
Proceeds from stock option exercises in other current assets	`ProceedsFromStockOptionsExercisedInOtherCurrentAssets`	-	USD	Annual
Proceeds from stock option exercises in other current assets	`ProceedsFromStockOptionsExercisedInOtherCurrentAssets`	-	USD	Annual
Proceeds from stock option exercises in other current assets	`ProceedsFromStockOptionsExercisedInOtherCurrentAssets`	$7.00K	USD	Annual
Operating lease liabilities arising from obtaining operating lease assets	`RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability`	$42.32M	USD	Annual
Operating lease liabilities arising from obtaining operating lease assets	`RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability`	-	USD	Annual
Financing lease liabilities arising from obtaining financing lease assets	`RightOfUseAssetObtainedInExchangeForFinanceLeaseLiability`	-	USD	Annual
Financing lease liabilities arising from obtaining financing lease assets	`RightOfUseAssetObtainedInExchangeForFinanceLeaseLiability`	$1.05M	USD	Annual

Stockholders Equity 25 line items

Line Item	Tag	Value	Unit	Period
Beginning balance	`StockholdersEquity`	$640.53M	USD	Point-in-time
Beginning balance	`StockholdersEquity`	$375.50M	USD	Point-in-time
Beginning balance	`StockholdersEquity`	$399.50M	USD	Point-in-time
Beginning balance	`StockholdersEquity`	$687.54M	USD	Point-in-time
Unrealized (loss) gain on available-for-sale securities	`OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax`	$-97.00K	USD	Annual
Unrealized (loss) gain on available-for-sale securities	`OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax`	$-782.00K	USD	Annual
Unrealized (loss) gain on available-for-sale securities	`OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax`	$2.37M	USD	Annual
Net loss	`NetIncomeLoss`	$-411.47M	USD	Annual
Net loss	`NetIncomeLoss`	$-346.03M	USD	Annual
Net loss	`NetIncomeLoss`	$-327.37M	USD	Annual
Stock-based compensation expense	`AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue`	$75.12M	USD	Annual
Stock-based compensation expense	`AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue`	$73.36M	USD	Annual
Stock-based compensation expense	`AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue`	$72.37M	USD	Annual
Issuance of common stock under stock incentive and employee stock purchase plan (in shares)	`StockIssuedDuringPeriodSharesStockOptionsExercised`	360,822.00	shares	Annual
Issuance of common stock under stock incentive and employee stock purchase plans	`StockIssuedDuringPeriodValueStockOptionsExercised`	$12.52M	USD	Annual
Issuance of common stock under stock incentive and employee stock purchase plans	`StockIssuedDuringPeriodValueStockOptionsExercised`	$30.22M	USD	Annual
Issuance of common stock under stock incentive and employee stock purchase plans	`StockIssuedDuringPeriodValueStockOptionsExercised`	$11.32M	USD	Annual
Issuance of common stock for follow-on offering (in shares)	`StockIssuedDuringPeriodSharesNewIssues`	9.49M	shares	Point-in-time
Issuance of common stock for follow-on offering	`StockIssuedDuringPeriodValueNewIssues`	$277.20M	USD	Annual
Issuance of common stock for follow-on offering	`StockIssuedDuringPeriodValueNewIssues`	$516.21M	USD	Annual
Other	`StockholdersEquityOther`	$391.00K	USD	Annual
Ending balance	`StockholdersEquity`	$640.53M	USD	Point-in-time
Ending balance	`StockholdersEquity`	$375.50M	USD	Point-in-time
Ending balance	`StockholdersEquity`	$399.50M	USD	Point-in-time
Ending balance	`StockholdersEquity`	$687.54M	USD	Point-in-time

Comprehensive Income 9 line items

Line Item	Tag	Value	Unit	Period
Net loss	`NetIncomeLoss`	$-411.47M	USD	Annual
Net loss	`NetIncomeLoss`	$-346.03M	USD	Annual
Net loss	`NetIncomeLoss`	$-327.37M	USD	Annual
Unrealized (loss) gain on available-for-sale securities	`OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax`	$-97.00K	USD	Annual
Unrealized (loss) gain on available-for-sale securities	`OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax`	$-782.00K	USD	Annual
Unrealized (loss) gain on available-for-sale securities	`OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax`	$2.37M	USD	Annual
Comprehensive loss	`ComprehensiveIncomeNetOfTax`	$-346.81M	USD	Annual
Comprehensive loss	`ComprehensiveIncomeNetOfTax`	$-327.47M	USD	Annual
Comprehensive loss	`ComprehensiveIncomeNetOfTax`	$-409.10M	USD	Annual

Data is extracted from SEC EDGAR XBRL filings. Values shown are as reported in the filing.