10-K Filing

AGIOS PHARMACEUTICALS, INC. CIK: 1439222 FY 2021

Filing Information

Form Type	10-K
Accession Number	`0001439222-22-000024`
Period End Date	20211231
Filing Date	20220224
Fiscal Year	2021
Fiscal Period	FY
XBRL Instance	agio-20211231_htm.xml

Filing Contents

This filing contains the following financial statements:

Balance Sheet 84 Income Statement 102 Cash Flow Statement 117 Stockholders Equity 26 Comprehensive Income 9

Balance Sheet 84 line items

Line Item	Tag	Value	Unit	Period
Preferred stock, par value (in usd per share)	`PreferredStockParOrStatedValuePerShare`	$0.00	USD	Point-in-time
Preferred stock, par value (in usd per share)	`PreferredStockParOrStatedValuePerShare`	$0.00	USD	Point-in-time
Preferred stock, shares authorized (in shares)	`PreferredStockSharesAuthorized`	25.00M	shares	Point-in-time
Preferred stock, shares authorized (in shares)	`PreferredStockSharesAuthorized`	25.00M	shares	Point-in-time
Preferred stock, shares issued (in shares)	`PreferredStockSharesIssued`	0.00	shares	Point-in-time
Cash and cash equivalents	`CashAndCashEquivalentsAtCarryingValue`	$127.44M	USD	Point-in-time
Cash and cash equivalents	`CashAndCashEquivalentsAtCarryingValue`	$203.13M	USD	Point-in-time
Preferred stock, shares issued (in shares)	`PreferredStockSharesIssued`	0.00	shares	Point-in-time
Marketable securities	`AvailableForSaleSecuritiesDebtSecuritiesCurrent`	$816.89M	USD	Point-in-time
Preferred stock, shares outstanding (in shares)	`PreferredStockSharesOutstanding`	0.00	shares	Point-in-time
Preferred stock, shares outstanding (in shares)	`PreferredStockSharesOutstanding`	0.00	shares	Point-in-time
Marketable securities	`AvailableForSaleSecuritiesDebtSecuritiesCurrent`	$445.49M	USD	Point-in-time
Other receivable	`AccountsAndOtherReceivablesNetCurrent`	-	USD	Point-in-time
Common stock, par value (in usd per share)	`CommonStockParOrStatedValuePerShare`	$0.00	USD	Point-in-time
Common stock, par value (in usd per share)	`CommonStockParOrStatedValuePerShare`	$0.00	USD	Point-in-time
Other receivable	`AccountsAndOtherReceivablesNetCurrent`	$4.38M	USD	Point-in-time
Common stock, shares authorized (in shares)	`CommonStockSharesAuthorized`	125.00M	shares	Point-in-time
Common stock, shares authorized (in shares)	`CommonStockSharesAuthorized`	125.00M	shares	Point-in-time
Prepaid expenses and other current assets	`PrepaidExpenseAndOtherAssetsCurrent`	$15.89M	USD	Point-in-time
Prepaid expenses and other current assets	`PrepaidExpenseAndOtherAssetsCurrent`	$39.84M	USD	Point-in-time
Current assets of discontinued operations	`AssetsOfDisposalGroupIncludingDiscontinuedOperationCurrent`	$47.86M	USD	Point-in-time
Current assets of discontinued operations	`AssetsOfDisposalGroupIncludingDiscontinuedOperationCurrent`	-	USD	Point-in-time
Common stock, shares issued (in shares)	`CommonStockSharesIssued`	69.29M	shares	Point-in-time
Common stock, shares issued (in shares)	`CommonStockSharesIssued`	70.55M	shares	Point-in-time
Common stock, shares outstanding (in shares)	`CommonStockSharesOutstanding`	69.29M	shares	Point-in-time
Total current assets	`AssetsCurrent`	$1.06B	USD	Point-in-time
Total current assets	`AssetsCurrent`	$636.68M	USD	Point-in-time
Common stock, shares outstanding (in shares)	`CommonStockSharesOutstanding`	54.33M	shares	Point-in-time
Marketable securities	`AvailableForSaleSecuritiesDebtSecuritiesNoncurrent`	$97.61M	USD	Point-in-time
Treasury stock (in shares)	`TreasuryStockShares`	16.22M	shares	Point-in-time
Treasury stock (in shares)	`TreasuryStockShares`	0.00	shares	Point-in-time
Marketable securities	`AvailableForSaleSecuritiesDebtSecuritiesNoncurrent`	$266.38M	USD	Point-in-time
Operating lease assets	`OperatingLeaseRightOfUseAsset`	$84.66M	USD	Point-in-time
Operating lease assets	`OperatingLeaseRightOfUseAsset`	$75.12M	USD	Point-in-time
Property and equipment, net	`PropertyPlantAndEquipmentNet`	$28.92M	USD	Point-in-time
Property and equipment, net	`PropertyPlantAndEquipmentNet`	$30.82M	USD	Point-in-time
Financing lease assets	`FinanceLeaseRightOfUseAsset`	$183.00K	USD	Point-in-time
Financing lease assets	`FinanceLeaseRightOfUseAsset`	$590.00K	USD	Point-in-time
Other non-current assets	`OtherAssetsNoncurrent`	$2.90M	USD	Point-in-time
Other non-current assets	`OtherAssetsNoncurrent`	-	USD	Point-in-time
Non-current assets of discontinued operations	`DisposalGroupIncludingDiscontinuedOperationAssetsNoncurrent`	$2.60M	USD	Point-in-time
Non-current assets of discontinued operations	`DisposalGroupIncludingDiscontinuedOperationAssetsNoncurrent`	-	USD	Point-in-time
Total assets	`Assets`	$852.95M	USD	Point-in-time
Total assets	`Assets`	$1.44B	USD	Point-in-time
Accounts payable	`AccountsPayableCurrent`	$16.70M	USD	Point-in-time
Accounts payable	`AccountsPayableCurrent`	$17.72M	USD	Point-in-time
Accrued expenses	`AccruedLiabilitiesCurrent`	$30.80M	USD	Point-in-time
Accrued expenses	`AccruedLiabilitiesCurrent`	$31.97M	USD	Point-in-time
Operating lease liabilities	`OperatingLeaseLiabilityCurrent`	$7.09M	USD	Point-in-time
Operating lease liabilities	`OperatingLeaseLiabilityCurrent`	$10.83M	USD	Point-in-time
Financing lease liabilities	`FinanceLeaseLiabilityCurrent`	$331.00K	USD	Point-in-time
Financing lease liabilities	`FinanceLeaseLiabilityCurrent`	$317.00K	USD	Point-in-time
Current liabilities of discontinued operations	`LiabilitiesOfDisposalGroupIncludingDiscontinuedOperationCurrent`	$38.46M	USD	Point-in-time
Current liabilities of discontinued operations	`LiabilitiesOfDisposalGroupIncludingDiscontinuedOperationCurrent`	-	USD	Point-in-time
Total current liabilities	`LiabilitiesCurrent`	$59.83M	USD	Point-in-time
Total current liabilities	`LiabilitiesCurrent`	$94.39M	USD	Point-in-time
Operating lease liabilities, net of current portion	`OperatingLeaseLiabilityNoncurrent`	$85.66M	USD	Point-in-time
Operating lease liabilities, net of current portion	`OperatingLeaseLiabilityNoncurrent`	$97.46M	USD	Point-in-time
Financing lease liabilities, net of current portion	`FinanceLeaseLiabilityNoncurrent`	$276.00K	USD	Point-in-time
Financing lease liabilities, net of current portion	`FinanceLeaseLiabilityNoncurrent`	$331.00K	USD	Point-in-time
Non-current liabilities of discontinued operations	`LiabilitiesOfDisposalGroupIncludingDiscontinuedOperationNoncurrent`	-	USD	Point-in-time
Non-current liabilities of discontinued operations	`LiabilitiesOfDisposalGroupIncludingDiscontinuedOperationNoncurrent`	$261.27M	USD	Point-in-time
Total liabilities	`Liabilities`	$145.76M	USD	Point-in-time
Total liabilities	`Liabilities`	$453.45M	USD	Point-in-time
Commitments and contingent liabilities (Note 9)	`CommitmentsAndContingencies`	-	USD	Point-in-time
Commitments and contingent liabilities (Note 9)	`CommitmentsAndContingencies`	-	USD	Point-in-time
Preferred stock, $0.001 par value; 25,000,000 shares authorized, no shares issued and outstanding at December 31, 2021 and 2020	`PreferredStockValue`	-	USD	Point-in-time
Preferred stock, $0.001 par value; 25,000,000 shares authorized, no shares issued and outstanding at December 31, 2021 and 2020	`PreferredStockValue`	-	USD	Point-in-time
Common stock, $0.001 par value; 125,000,000 shares authorized; 70,550,631 shares issued and 54,334,220 outstanding at December 31, 2021 and 69,293,920 shares issued and outstanding at December 31, 2020	`CommonStockValue`	$69.00K	USD	Point-in-time
Common stock, $0.001 par value; 125,000,000 shares authorized; 70,550,631 shares issued and 54,334,220 outstanding at December 31, 2021 and 69,293,920 shares issued and outstanding at December 31, 2020	`CommonStockValue`	$71.00K	USD	Point-in-time
Additional paid-in capital	`AdditionalPaidInCapitalCommonStock`	$2.33B	USD	Point-in-time
Additional paid-in capital	`AdditionalPaidInCapitalCommonStock`	$2.24B	USD	Point-in-time
Accumulated other comprehensive (loss) income	`AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax`	$-1.20M	USD	Point-in-time
Accumulated other comprehensive (loss) income	`AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax`	$105.00K	USD	Point-in-time
Accumulated deficit	`RetainedEarningsAccumulatedDeficit`	$-238.76M	USD	Point-in-time
Accumulated deficit	`RetainedEarningsAccumulatedDeficit`	$-1.84B	USD	Point-in-time
Treasury stock, at cost (16,216,411 shares at December 31, 2021 and no shares at December 31, 2020)	`TreasuryStockValue`	$802.49M	USD	Point-in-time
Treasury stock, at cost (16,216,411 shares at December 31, 2021 and no shares at December 31, 2020)	`TreasuryStockValue`	-	USD	Point-in-time
Total stockholders equity	`StockholdersEquity`	$640.53M	USD	Point-in-time
Total stockholders equity	`StockholdersEquity`	$687.54M	USD	Point-in-time
Total stockholders equity	`StockholdersEquity`	$399.50M	USD	Point-in-time
Total stockholders equity	`StockholdersEquity`	$1.29B	USD	Point-in-time
Total liabilities and stockholders equity	`LiabilitiesAndStockholdersEquity`	$1.44B	USD	Point-in-time
Total liabilities and stockholders equity	`LiabilitiesAndStockholdersEquity`	$852.95M	USD	Point-in-time

Income Statement 102 line items

Line Item	Tag	Value	Unit	Period
Research and development	`ResearchAndDevelopmentExpense`	$220.81M	USD	Annual
Research and development	`ResearchAndDevelopmentExpense`	$256.97M	USD	Annual
Research and development	`ResearchAndDevelopmentExpense`	$214.26M	USD	Annual
Selling, general and administrative	`SellingGeneralAndAdministrativeExpense`	$102.01M	USD	Annual
Selling, general and administrative	`SellingGeneralAndAdministrativeExpense`	$121.44M	USD	Annual
Selling, general and administrative	`SellingGeneralAndAdministrativeExpense`	$115.11M	USD	Annual
Total cost and expenses	`CostsAndExpenses`	$335.92M	USD	Annual
Total cost and expenses	`CostsAndExpenses`	$316.27M	USD	Annual
Total cost and expenses	`CostsAndExpenses`	$378.42M	USD	Annual
Net income (loss) from discontinued operations, net of tax	`OperatingIncomeLoss`	$-378.42M	USD	Annual
Net income (loss) from discontinued operations, net of tax	`OperatingIncomeLoss`	$-316.27M	USD	Annual
Net income (loss) from discontinued operations, net of tax	`OperatingIncomeLoss`	$-335.92M	USD	Annual
Gain on sale of oncology business	`GainLossOnSaleOfBusiness`	-	USD	Annual
Gain on sale of oncology business	`GainLossOnSaleOfBusiness`	$6.64M	USD	Annual
Gain on sale of oncology business	`GainLossOnSaleOfBusiness`	-	USD	Annual
Interest income, net	`InvestmentIncomeInterest`	$836.00K	USD	Annual
Interest income, net	`InvestmentIncomeInterest`	$6.61M	USD	Annual
Interest income, net	`InvestmentIncomeInterest`	$14.86M	USD	Annual
Other income, net	`OtherNonoperatingIncomeExpense`	-	USD	Annual
Other income, net	`OtherNonoperatingIncomeExpense`	-	USD	Annual
Other income, net	`OtherNonoperatingIncomeExpense`	$14.43M	USD	Annual
Total	`IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest`	$-98.58M	USD	1 Quarter
Total	`IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest`	$-81.50M	USD	1 Quarter
Total	`IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest`	$-90.88M	USD	1 Quarter
Total	`IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest`	$-84.26M	USD	1 Quarter
Total	`IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest`	$-329.31M	USD	Annual
Total	`IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest`	$-356.51M	USD	Annual
Total	`IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest`	$-84.54M	USD	1 Quarter
Total	`IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest`	$-301.41M	USD	Annual
Total	`IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest`	$-79.17M	USD	1 Quarter
Total	`IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest`	$-84.09M	USD	1 Quarter
Total	`IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest`	$-82.79M	USD	1 Quarter
Less: Net income (loss) from discontinued operations	`IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity`	$-19.80M	USD	1 Quarter
Less: Net income (loss) from discontinued operations	`IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity`	$-110.06M	USD	Annual
Less: Net income (loss) from discontinued operations	`IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity`	$-4.51M	USD	1 Quarter
Less: Net income (loss) from discontinued operations	`IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity`	$3.96M	USD	1 Quarter
Less: Net income (loss) from discontinued operations	`IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity`	$-13.12M	USD	1 Quarter
Less: Net income (loss) from discontinued operations	`IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity`	$43.84M	USD	1 Quarter
Less: Net income (loss) from discontinued operations	`IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity`	$-3.43M	USD	1 Quarter
Less: Net income (loss) from discontinued operations	`IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity`	$-8.98M	USD	1 Quarter
Less: Net income (loss) from discontinued operations	`IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity`	$1.96B	USD	Annual
Less: Net income (loss) from discontinued operations	`IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity`	$1.97B	USD	1 Quarter
Less: Net income (loss) from discontinued operations	`IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity`	$1.94M	USD	Annual
Net income (loss)	`NetIncomeLoss`	$1.60B	USD	Annual
Net income (loss)	`NetIncomeLoss`	$-411.47M	USD	Annual
Net income (loss)	`NetIncomeLoss`	$-327.37M	USD	Annual
Net loss from continuing operations per share - basic (in usd per share)	`IncomeLossFromContinuingOperationsPerBasicShare`	$-1.81	USD	1 Quarter
Net loss from continuing operations per share - basic (in usd per share)	`IncomeLossFromContinuingOperationsPerBasicShare`	$-4.77	USD	Annual
Net loss from continuing operations per share - basic (in usd per share)	`IncomeLossFromContinuingOperationsPerBasicShare`	$-1.18	USD	1 Quarter
Net loss from continuing operations per share - basic (in usd per share)	`IncomeLossFromContinuingOperationsPerBasicShare`	$-1.48	USD	1 Quarter
Net loss from continuing operations per share - basic (in usd per share)	`IncomeLossFromContinuingOperationsPerBasicShare`	$-1.22	USD	1 Quarter
Net loss from continuing operations per share - basic (in usd per share)	`IncomeLossFromContinuingOperationsPerBasicShare`	$-5.90	USD	Annual
Net loss from continuing operations per share - basic (in usd per share)	`IncomeLossFromContinuingOperationsPerBasicShare`	$-1.23	USD	1 Quarter
Net loss from continuing operations per share - basic (in usd per share)	`IncomeLossFromContinuingOperationsPerBasicShare`	$-1.15	USD	1 Quarter
Net loss from continuing operations per share - basic (in usd per share)	`IncomeLossFromContinuingOperationsPerBasicShare`	$-5.02	USD	Annual
Net loss from continuing operations per share - basic (in usd per share)	`IncomeLossFromContinuingOperationsPerBasicShare`	$-1.31	USD	1 Quarter
Net loss from continuing operations per share - basic (in usd per share)	`IncomeLossFromContinuingOperationsPerBasicShare`	$-1.36	USD	1 Quarter
Net loss from continuing operations per share - diluted (in usd per share)	`IncomeLossFromContinuingOperationsPerDilutedShare`	$-0.19	USD	1 Quarter
Net loss from continuing operations per share - diluted (in usd per share)	`IncomeLossFromContinuingOperationsPerDilutedShare`	$0.64	USD	1 Quarter
Net loss from continuing operations per share - diluted (in usd per share)	`IncomeLossFromContinuingOperationsPerDilutedShare`	$-0.08	USD	1 Quarter
Net loss from continuing operations per share - diluted (in usd per share)	`IncomeLossFromContinuingOperationsPerDilutedShare`	$-4.77	USD	Annual
Net loss from continuing operations per share - diluted (in usd per share)	`IncomeLossFromContinuingOperationsPerDilutedShare`	$-0.06	USD	1 Quarter
Net loss from continuing operations per share - diluted (in usd per share)	`IncomeLossFromContinuingOperationsPerDilutedShare`	$-5.90	USD	Annual
Net loss from continuing operations per share - diluted (in usd per share)	`IncomeLossFromContinuingOperationsPerDilutedShare`	$-0.29	USD	1 Quarter
Net loss from continuing operations per share - diluted (in usd per share)	`IncomeLossFromContinuingOperationsPerDilutedShare`	$0.07	USD	1 Quarter
Net loss from continuing operations per share - diluted (in usd per share)	`IncomeLossFromContinuingOperationsPerDilutedShare`	$28.26	USD	1 Quarter
Net loss from continuing operations per share - diluted (in usd per share)	`IncomeLossFromContinuingOperationsPerDilutedShare`	$-0.13	USD	1 Quarter
Net loss from continuing operations per share - diluted (in usd per share)	`IncomeLossFromContinuingOperationsPerDilutedShare`	$-5.02	USD	Annual
Net (loss) income from discontinued operations per share - basic (in usd per share)	`IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare`	$0.03	USD	Annual
Net (loss) income from discontinued operations per share - basic (in usd per share)	`IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare`	$-1.84	USD	Annual
Net (loss) income from discontinued operations per share - basic (in usd per share)	`IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare`	$32.45	USD	Annual
Net (loss) income from discontinued operations per share - diluted (in usd per share)	`IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare`	$0.03	USD	Annual
Net (loss) income from discontinued operations per share - diluted (in usd per share)	`IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare`	$32.45	USD	Annual
Net (loss) income from discontinued operations per share - diluted (in usd per share)	`IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare`	$-1.84	USD	Annual
Net loss per share basic (in usd per share)	`EarningsPerShareBasic`	$26.55	USD	Annual
Net loss per share basic (in usd per share)	`EarningsPerShareBasic`	$26.95	USD	1 Quarter
Net loss per share basic (in usd per share)	`EarningsPerShareBasic`	$-1.31	USD	1 Quarter
Net loss per share basic (in usd per share)	`EarningsPerShareBasic`	$-1.41	USD	1 Quarter
Net loss per share basic (in usd per share)	`EarningsPerShareBasic`	$-1.41	USD	1 Quarter
Net loss per share basic (in usd per share)	`EarningsPerShareBasic`	$-6.86	USD	Annual
Net loss per share basic (in usd per share)	`EarningsPerShareBasic`	$-1.56	USD	1 Quarter
Net loss per share basic (in usd per share)	`EarningsPerShareBasic`	$-1.74	USD	1 Quarter
Net loss per share basic (in usd per share)	`EarningsPerShareBasic`	$-1.43	USD	1 Quarter
Net loss per share basic (in usd per share)	`EarningsPerShareBasic`	$-0.59	USD	1 Quarter
Net loss per share basic (in usd per share)	`EarningsPerShareBasic`	$-4.74	USD	Annual
Net loss per share diluted (in usd per share)	`EarningsPerShareDiluted`	$26.95	USD	1 Quarter
Net loss per share diluted (in usd per share)	`EarningsPerShareDiluted`	$-1.31	USD	1 Quarter
Net loss per share diluted (in usd per share)	`EarningsPerShareDiluted`	$26.55	USD	Annual
Net loss per share diluted (in usd per share)	`EarningsPerShareDiluted`	$-1.41	USD	1 Quarter
Net loss per share diluted (in usd per share)	`EarningsPerShareDiluted`	$-4.74	USD	Annual
Net loss per share diluted (in usd per share)	`EarningsPerShareDiluted`	$-1.41	USD	1 Quarter
Net loss per share diluted (in usd per share)	`EarningsPerShareDiluted`	$-1.43	USD	1 Quarter
Net loss per share diluted (in usd per share)	`EarningsPerShareDiluted`	$-1.56	USD	1 Quarter
Net loss per share diluted (in usd per share)	`EarningsPerShareDiluted`	$-0.59	USD	1 Quarter
Net loss per share diluted (in usd per share)	`EarningsPerShareDiluted`	$-6.86	USD	Annual
Net loss per share diluted (in usd per share)	`EarningsPerShareDiluted`	$-1.74	USD	1 Quarter
Weighted-average number of common shares used in computing net loss per share basic (in shares)	`WeightedAverageNumberOfSharesOutstandingBasic`	60.45M	shares	Annual
Weighted-average number of common shares used in computing net loss per share basic (in shares)	`WeightedAverageNumberOfSharesOutstandingBasic`	69.00M	shares	Annual
Weighted-average number of common shares used in computing net loss per share basic (in shares)	`WeightedAverageNumberOfSharesOutstandingBasic`	59.99M	shares	Annual
Weighted-average number of common shares used in computing net loss per share diluted (in shares)	`WeightedAverageNumberOfDilutedSharesOutstanding`	60.45M	shares	Annual
Weighted-average number of common shares used in computing net loss per share diluted (in shares)	`WeightedAverageNumberOfDilutedSharesOutstanding`	59.99M	shares	Annual
Weighted-average number of common shares used in computing net loss per share diluted (in shares)	`WeightedAverageNumberOfDilutedSharesOutstanding`	69.00M	shares	Annual

Cash Flow Statement 117 line items

Line Item	Tag	Value	Unit	Period
Net income (loss)	`NetIncomeLoss`	$1.60B	USD	Annual
Net income (loss)	`NetIncomeLoss`	$-411.47M	USD	Annual
Net income (loss)	`NetIncomeLoss`	$-327.37M	USD	Annual
Less: Net income (loss) from discontinued operations	`IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity`	$-19.80M	USD	1 Quarter
Less: Net income (loss) from discontinued operations	`IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity`	$-110.06M	USD	Annual
Less: Net income (loss) from discontinued operations	`IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity`	$-4.51M	USD	1 Quarter
Less: Net income (loss) from discontinued operations	`IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity`	$3.96M	USD	1 Quarter
Less: Net income (loss) from discontinued operations	`IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity`	$-13.12M	USD	1 Quarter
Less: Net income (loss) from discontinued operations	`IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity`	$43.84M	USD	1 Quarter
Less: Net income (loss) from discontinued operations	`IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity`	$-3.43M	USD	1 Quarter
Less: Net income (loss) from discontinued operations	`IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity`	$-8.98M	USD	1 Quarter
Less: Net income (loss) from discontinued operations	`IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity`	$1.96B	USD	Annual
Less: Net income (loss) from discontinued operations	`IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity`	$1.97B	USD	1 Quarter
Less: Net income (loss) from discontinued operations	`IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity`	$1.94M	USD	Annual
Net loss from continuing operations	`IncomeLossFromContinuingOperations`	$-356.51M	USD	Annual
Net loss from continuing operations	`IncomeLossFromContinuingOperations`	$-301.41M	USD	Annual
Net loss from continuing operations	`IncomeLossFromContinuingOperations`	$-329.31M	USD	Annual
Depreciation and amortization	`OtherDepreciationAndAmortization`	$8.09M	USD	Annual
Depreciation and amortization	`OtherDepreciationAndAmortization`	$9.79M	USD	Annual
Depreciation and amortization	`OtherDepreciationAndAmortization`	$9.24M	USD	Annual
Stock-based compensation expense	`ShareBasedCompensation`	$53.51M	USD	Annual
Stock-based compensation expense	`ShareBasedCompensation`	$58.05M	USD	Annual
Stock-based compensation expense	`ShareBasedCompensation`	$61.60M	USD	Annual
Net amortization of premium (accretion of discount) on marketable securities	`AccretionAmortizationOfDiscountsAndPremiumsInvestments`	$3.19M	USD	Annual
Net amortization of premium (accretion of discount) on marketable securities	`AccretionAmortizationOfDiscountsAndPremiumsInvestments`	$-6.95M	USD	Annual
Net amortization of premium (accretion of discount) on marketable securities	`AccretionAmortizationOfDiscountsAndPremiumsInvestments`	$-3.02M	USD	Annual
Loss on disposal of property and equipment	`GainLossOnSaleOfPropertyPlantEquipment`	$-12.00K	USD	Annual
Loss on disposal of property and equipment	`GainLossOnSaleOfPropertyPlantEquipment`	$-1.05M	USD	Annual
Loss on disposal of property and equipment	`GainLossOnSaleOfPropertyPlantEquipment`	-	USD	Annual
Non-cash operating lease expense	`OperatingLeaseRightOfUseAssetAmortizationExpense`	$8.98M	USD	Annual
Non-cash operating lease expense	`OperatingLeaseRightOfUseAssetAmortizationExpense`	$9.54M	USD	Annual
Non-cash operating lease expense	`OperatingLeaseRightOfUseAssetAmortizationExpense`	$8.53M	USD	Annual
Other receivables	`IncreaseDecreaseInContractWithCustomerAsset`	-	USD	Annual
Other receivables	`IncreaseDecreaseInContractWithCustomerAsset`	$4.38M	USD	Annual
Other receivables	`IncreaseDecreaseInContractWithCustomerAsset`	-	USD	Annual
Prepaid expenses and other current and non-current assets	`IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets`	$26.85M	USD	Annual
Prepaid expenses and other current and non-current assets	`IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets`	$3.75M	USD	Annual
Prepaid expenses and other current and non-current assets	`IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets`	$3.00K	USD	Annual
Accounts payable	`IncreaseDecreaseInAccountsPayable`	$1.86M	USD	Annual
Accounts payable	`IncreaseDecreaseInAccountsPayable`	$3.33M	USD	Annual
Accounts payable	`IncreaseDecreaseInAccountsPayable`	$4.16M	USD	Annual
Accrued expenses	`IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities`	$66.00K	USD	Annual
Accrued expenses	`IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities`	$-825.00K	USD	Annual
Accrued expenses	`IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities`	$6.76M	USD	Annual
Operating lease liabilities	`IncreaseDecreaseInOperatingLeaseLiability`	$-6.86M	USD	Annual
Operating lease liabilities	`IncreaseDecreaseInOperatingLeaseLiability`	$-7.53M	USD	Annual
Operating lease liabilities	`IncreaseDecreaseInOperatingLeaseLiability`	$-8.13M	USD	Annual
Net cash used in operating activities	`NetCashProvidedByUsedInOperatingActivitiesContinuingOperations`	$-243.94M	USD	Annual
Net cash used in operating activities	`NetCashProvidedByUsedInOperatingActivitiesContinuingOperations`	$-314.09M	USD	Annual
Net cash used in operating activities	`NetCashProvidedByUsedInOperatingActivitiesContinuingOperations`	$-236.16M	USD	Annual
Net cash used in operating activities - discontinued operations	`CashProvidedByUsedInOperatingActivitiesDiscontinuedOperations`	$-46.81M	USD	Annual
Net cash used in operating activities - discontinued operations	`CashProvidedByUsedInOperatingActivitiesDiscontinuedOperations`	$-134.47M	USD	Annual
Net cash used in operating activities - discontinued operations	`CashProvidedByUsedInOperatingActivitiesDiscontinuedOperations`	$-93.23M	USD	Annual
Net cash used in operating activities	`NetCashProvidedByUsedInOperatingActivities`	$-290.76M	USD	Annual
Net cash used in operating activities	`NetCashProvidedByUsedInOperatingActivities`	$-407.32M	USD	Annual
Net cash used in operating activities	`NetCashProvidedByUsedInOperatingActivities`	$-370.62M	USD	Annual
Purchases of marketable securities	`PaymentsToAcquireAvailableForSaleSecuritiesDebt`	$557.03M	USD	Annual
Purchases of marketable securities	`PaymentsToAcquireAvailableForSaleSecuritiesDebt`	$488.57M	USD	Annual
Purchases of marketable securities	`PaymentsToAcquireAvailableForSaleSecuritiesDebt`	$1.38B	USD	Annual
Proceeds from maturities and sales of marketable securities	`ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities`	$647.68M	USD	Annual
Proceeds from maturities and sales of marketable securities	`ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities`	$829.80M	USD	Annual
Proceeds from maturities and sales of marketable securities	`ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities`	$592.18M	USD	Annual
Purchases of property and equipment	`PaymentsToAcquirePropertyPlantAndEquipment`	$5.74M	USD	Annual
Purchases of property and equipment	`PaymentsToAcquirePropertyPlantAndEquipment`	$12.03M	USD	Annual
Purchases of property and equipment	`PaymentsToAcquirePropertyPlantAndEquipment`	$14.11M	USD	Annual
Net cash (used in) provided by investing activities	`NetCashProvidedByUsedInInvestingActivitiesContinuingOperations`	$91.58M	USD	Annual
Net cash (used in) provided by investing activities	`NetCashProvidedByUsedInInvestingActivitiesContinuingOperations`	$-554.16M	USD	Annual
Net cash (used in) provided by investing activities	`NetCashProvidedByUsedInInvestingActivitiesContinuingOperations`	$76.55M	USD	Annual
Net cash provided by (used in) investing activities - discontinued operations	`CashProvidedByUsedInInvestingActivitiesDiscontinuedOperations`	$1.80B	USD	Annual
Net cash provided by (used in) investing activities - discontinued operations	`CashProvidedByUsedInInvestingActivitiesDiscontinuedOperations`	$-143.00K	USD	Annual
Net cash provided by (used in) investing activities - discontinued operations	`CashProvidedByUsedInInvestingActivitiesDiscontinuedOperations`	$-803.00K	USD	Annual
Net cash provided by investing activities	`NetCashProvidedByUsedInInvestingActivities`	$91.44M	USD	Annual
Net cash provided by investing activities	`NetCashProvidedByUsedInInvestingActivities`	$1.25B	USD	Annual
Net cash provided by investing activities	`NetCashProvidedByUsedInInvestingActivities`	$75.75M	USD	Annual
Payments on financing lease obligations	`FinanceLeasePrincipalPayments`	$113.00K	USD	Annual
Payments on financing lease obligations	`FinanceLeasePrincipalPayments`	$336.00K	USD	Annual
Payments on financing lease obligations	`FinanceLeasePrincipalPayments`	$578.00K	USD	Annual
Purchase of treasury stock	`PaymentsForRepurchaseOfEquity`	-	USD	Annual
Purchase of treasury stock	`PaymentsForRepurchaseOfEquity`	$802.49M	USD	Annual
Purchase of treasury stock	`PaymentsForRepurchaseOfEquity`	-	USD	Annual
Proceeds from public offering of common stock, net of reimbursements	`ProceedsFromIssuanceOfCommonStock`	-	USD	Annual
Proceeds from public offering of common stock, net of reimbursements	`ProceedsFromIssuanceOfCommonStock`	$277.20M	USD	Annual
Net proceeds from stock option exercises and employee stock purchase plan	`ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions`	$12.52M	USD	Annual
Net proceeds from stock option exercises and employee stock purchase plan	`ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions`	$11.32M	USD	Annual
Net proceeds from stock option exercises and employee stock purchase plan	`ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions`	$37.30M	USD	Annual
Net cash (used in) provided by financing activities	`NetCashProvidedByUsedInFinancingActivitiesContinuingOperations`	$10.98M	USD	Annual
Net cash (used in) provided by financing activities	`NetCashProvidedByUsedInFinancingActivitiesContinuingOperations`	$289.61M	USD	Annual
Net cash (used in) provided by financing activities	`NetCashProvidedByUsedInFinancingActivitiesContinuingOperations`	$-765.77M	USD	Annual
Net cash provided by financing activities - discontinued operations	`CashProvidedByUsedInFinancingActivitiesDiscontinuedOperations`	-	USD	Annual
Net cash provided by financing activities - discontinued operations	`CashProvidedByUsedInFinancingActivitiesDiscontinuedOperations`	$250.54M	USD	Annual
Net cash provided by financing activities - discontinued operations	`CashProvidedByUsedInFinancingActivitiesDiscontinuedOperations`	-	USD	Annual
Net cash (used in) provided by financing activities	`NetCashProvidedByUsedInFinancingActivities`	$261.52M	USD	Annual
Net cash (used in) provided by financing activities	`NetCashProvidedByUsedInFinancingActivities`	$289.61M	USD	Annual
Net cash (used in) provided by financing activities	`NetCashProvidedByUsedInFinancingActivities`	$-765.77M	USD	Annual
Net change in cash and cash equivalents	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect`	$46.51M	USD	Annual
Net change in cash and cash equivalents	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect`	$10.43M	USD	Annual
Net change in cash and cash equivalents	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect`	$75.69M	USD	Annual
Cash and cash equivalents at beginning of the period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$70.50M	USD	Point-in-time
Cash and cash equivalents at beginning of the period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$127.44M	USD	Point-in-time
Cash and cash equivalents at beginning of the period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$80.93M	USD	Point-in-time
Cash and cash equivalents at beginning of the period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$203.13M	USD	Point-in-time
Cash and cash equivalents at end of the period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$70.50M	USD	Point-in-time
Cash and cash equivalents at end of the period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$127.44M	USD	Point-in-time
Cash and cash equivalents at end of the period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$80.93M	USD	Point-in-time
Cash and cash equivalents at end of the period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$203.13M	USD	Point-in-time
Additions to property and equipment in accounts payable and accrued expenses	`CapitalExpendituresIncurredButNotYetPaid`	$1.68M	USD	Annual
Additions to property and equipment in accounts payable and accrued expenses	`CapitalExpendituresIncurredButNotYetPaid`	$465.00K	USD	Annual
Additions to property and equipment in accounts payable and accrued expenses	`CapitalExpendituresIncurredButNotYetPaid`	$5.17M	USD	Annual
Cash taxes paid	`IncomeTaxesPaid`	-	USD	Annual
Cash taxes paid	`IncomeTaxesPaid`	-	USD	Annual
Cash taxes paid	`IncomeTaxesPaid`	$16.08M	USD	Annual
Operating lease liabilities arising from obtaining operating lease assets	`RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability`	-	USD	Annual
Operating lease liabilities arising from obtaining operating lease assets	`RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability`	-	USD	Annual
Operating lease liabilities arising from obtaining operating lease assets	`RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability`	$42.32M	USD	Annual
Financing lease liabilities arising from obtaining financing lease assets	`RightOfUseAssetObtainedInExchangeForFinanceLeaseLiability`	$511.00K	USD	Annual
Financing lease liabilities arising from obtaining financing lease assets	`RightOfUseAssetObtainedInExchangeForFinanceLeaseLiability`	$1.05M	USD	Annual
Financing lease liabilities arising from obtaining financing lease assets	`RightOfUseAssetObtainedInExchangeForFinanceLeaseLiability`	-	USD	Annual

Stockholders Equity 26 line items

Line Item	Tag	Value	Unit	Period
Beginning balance	`StockholdersEquity`	$640.53M	USD	Point-in-time
Beginning balance	`StockholdersEquity`	$687.54M	USD	Point-in-time
Beginning balance	`StockholdersEquity`	$399.50M	USD	Point-in-time
Beginning balance	`StockholdersEquity`	$1.29B	USD	Point-in-time
Unrealized (loss) gain on available-for-sale securities	`OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax`	$-1.30M	USD	Annual
Unrealized (loss) gain on available-for-sale securities	`OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax`	$-97.00K	USD	Annual
Unrealized (loss) gain on available-for-sale securities	`OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax`	$2.37M	USD	Annual
Net income (loss)	`NetIncomeLoss`	$1.60B	USD	Annual
Net income (loss)	`NetIncomeLoss`	$-411.47M	USD	Annual
Net income (loss)	`NetIncomeLoss`	$-327.37M	USD	Annual
Stock-based compensation expense	`AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue`	$58.05M	USD	Annual
Stock-based compensation expense	`AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue`	$53.51M	USD	Annual
Stock-based compensation expense	`AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue`	$61.60M	USD	Annual
Issuance of common stock under stock incentive and employee stock purchase plan (in shares)	`StockIssuedDuringPeriodSharesStockOptionsExercised`	758,685.00	shares	Annual
Issuance of common stock under stock incentive and employee stock purchase plans	`StockIssuedDuringPeriodValueStockOptionsExercised`	$37.30M	USD	Annual
Issuance of common stock under stock incentive and employee stock purchase plans	`StockIssuedDuringPeriodValueStockOptionsExercised`	$12.52M	USD	Annual
Issuance of common stock under stock incentive and employee stock purchase plans	`StockIssuedDuringPeriodValueStockOptionsExercised`	$11.32M	USD	Annual
Issuance of common stock for follow-on offering	`StockIssuedDuringPeriodValueNewIssues`	$277.20M	USD	Annual
Disposition of oncology business	`StockholdersEquityDispositionOfBusiness`	$-13.52M	USD	Annual
Disposition of oncology business	`StockholdersEquityDispositionOfBusiness`	$-745.00K	USD	Annual
Disposition of oncology business	`StockholdersEquityDispositionOfBusiness`	$-14.32M	USD	Annual
Repurchase of common stock	`TreasuryStockValueAcquiredCostMethod`	$802.49M	USD	Annual
Ending balance	`StockholdersEquity`	$640.53M	USD	Point-in-time
Ending balance	`StockholdersEquity`	$687.54M	USD	Point-in-time
Ending balance	`StockholdersEquity`	$399.50M	USD	Point-in-time
Ending balance	`StockholdersEquity`	$1.29B	USD	Point-in-time

Comprehensive Income 9 line items

Line Item	Tag	Value	Unit	Period
Net income (loss)	`NetIncomeLoss`	$1.60B	USD	Annual
Net income (loss)	`NetIncomeLoss`	$-411.47M	USD	Annual
Net income (loss)	`NetIncomeLoss`	$-327.37M	USD	Annual
Unrealized (loss) gain on available-for-sale securities	`OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax`	$-1.30M	USD	Annual
Unrealized (loss) gain on available-for-sale securities	`OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax`	$-97.00K	USD	Annual
Unrealized (loss) gain on available-for-sale securities	`OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax`	$2.37M	USD	Annual
Comprehensive income (loss)	`ComprehensiveIncomeNetOfTax`	$1.60B	USD	Annual
Comprehensive income (loss)	`ComprehensiveIncomeNetOfTax`	$-409.10M	USD	Annual
Comprehensive income (loss)	`ComprehensiveIncomeNetOfTax`	$-327.47M	USD	Annual

Data is extracted from SEC EDGAR XBRL filings. Values shown are as reported in the filing.