10-K Filing

AGIOS PHARMACEUTICALS, INC. CIK: 1439222 FY 2022

Filing Information

Form Type	10-K
Accession Number	`0001439222-23-000039`
Period End Date	20221231
Filing Date	20230223
Fiscal Year	2022
Fiscal Period	FY
XBRL Instance	agio-20221231_htm.xml

Filing Contents

This filing contains the following financial statements:

Balance Sheet 81 Income Statement 63 Cash Flow Statement 122 Stockholders Equity 28 Comprehensive Income 9

Balance Sheet 81 line items

Line Item	Tag	Value	Unit	Period
Preferred stock, par value (in usd per share)	`PreferredStockParOrStatedValuePerShare`	$0.00	USD	Point-in-time
Preferred stock, par value (in usd per share)	`PreferredStockParOrStatedValuePerShare`	$0.00	USD	Point-in-time
Preferred stock, shares authorized (in shares)	`PreferredStockSharesAuthorized`	25.00M	shares	Point-in-time
Preferred stock, shares authorized (in shares)	`PreferredStockSharesAuthorized`	25.00M	shares	Point-in-time
Preferred stock, shares issued (in shares)	`PreferredStockSharesIssued`	0.00	shares	Point-in-time
Cash and cash equivalents	`CashAndCashEquivalentsAtCarryingValue`	$139.26M	USD	Point-in-time
Preferred stock, shares issued (in shares)	`PreferredStockSharesIssued`	0.00	shares	Point-in-time
Cash and cash equivalents	`CashAndCashEquivalentsAtCarryingValue`	$203.13M	USD	Point-in-time
Marketable securities	`AvailableForSaleSecuritiesDebtSecuritiesCurrent`	$643.86M	USD	Point-in-time
Preferred stock, shares outstanding (in shares)	`PreferredStockSharesOutstanding`	0.00	shares	Point-in-time
Marketable securities	`AvailableForSaleSecuritiesDebtSecuritiesCurrent`	$816.89M	USD	Point-in-time
Preferred stock, shares outstanding (in shares)	`PreferredStockSharesOutstanding`	0.00	shares	Point-in-time
Common stock, par value (in usd per share)	`CommonStockParOrStatedValuePerShare`	$0.00	USD	Point-in-time
Accounts receivable, net	`ContractWithCustomerAssetNetCurrent`	-	USD	Point-in-time
Accounts receivable, net	`ContractWithCustomerAssetNetCurrent`	$2.21M	USD	Point-in-time
Common stock, par value (in usd per share)	`CommonStockParOrStatedValuePerShare`	$0.00	USD	Point-in-time
Common stock, shares authorized (in shares)	`CommonStockSharesAuthorized`	125.00M	shares	Point-in-time
Other receivable	`AccountsAndOtherReceivablesNetCurrent`	$4.38M	USD	Point-in-time
Common stock, shares authorized (in shares)	`CommonStockSharesAuthorized`	125.00M	shares	Point-in-time
Other receivable	`AccountsAndOtherReceivablesNetCurrent`	-	USD	Point-in-time
Inventory	`InventoryNet`	$8.49M	USD	Point-in-time
Inventory	`InventoryNet`	-	USD	Point-in-time
Common stock, shares issued (in shares)	`CommonStockSharesIssued`	71.26M	shares	Point-in-time
Common stock, shares issued (in shares)	`CommonStockSharesIssued`	70.55M	shares	Point-in-time
Prepaid expenses and other current assets	`PrepaidExpenseAndOtherAssetsCurrent`	$38.95M	USD	Point-in-time
Common stock, shares outstanding (in shares)	`CommonStockSharesOutstanding`	55.04M	shares	Point-in-time
Common stock, shares outstanding (in shares)	`CommonStockSharesOutstanding`	54.33M	shares	Point-in-time
Prepaid expenses and other current assets	`PrepaidExpenseAndOtherAssetsCurrent`	$39.84M	USD	Point-in-time
Total current assets	`AssetsCurrent`	$832.77M	USD	Point-in-time
Total current assets	`AssetsCurrent`	$1.06B	USD	Point-in-time
Treasury stock (in shares)	`TreasuryStockShares`	16.22M	shares	Point-in-time
Marketable securities	`AvailableForSaleSecuritiesDebtSecuritiesNoncurrent`	$266.38M	USD	Point-in-time
Marketable securities	`AvailableForSaleSecuritiesDebtSecuritiesNoncurrent`	$313.87M	USD	Point-in-time
Operating lease assets	`OperatingLeaseRightOfUseAsset`	$75.12M	USD	Point-in-time
Operating lease assets	`OperatingLeaseRightOfUseAsset`	$65.13M	USD	Point-in-time
Property and equipment, net	`PropertyPlantAndEquipmentNet`	$22.99M	USD	Point-in-time
Property and equipment, net	`PropertyPlantAndEquipmentNet`	$28.92M	USD	Point-in-time
Financing lease assets	`FinanceLeaseRightOfUseAsset`	$183.00K	USD	Point-in-time
Financing lease assets	`FinanceLeaseRightOfUseAsset`	-	USD	Point-in-time
Other non-current assets	`OtherAssetsNoncurrent`	$3.96M	USD	Point-in-time
Other non-current assets	`OtherAssetsNoncurrent`	$2.90M	USD	Point-in-time
Total assets	`Assets`	$1.24B	USD	Point-in-time
Total assets	`Assets`	$1.44B	USD	Point-in-time
Accounts payable	`AccountsPayableCurrent`	$16.70M	USD	Point-in-time
Accounts payable	`AccountsPayableCurrent`	$18.62M	USD	Point-in-time
Accrued expenses	`AccruedLiabilitiesCurrent`	$30.35M	USD	Point-in-time
Accrued expenses	`AccruedLiabilitiesCurrent`	$31.97M	USD	Point-in-time
Operating lease liabilities	`OperatingLeaseLiabilityCurrent`	$13.66M	USD	Point-in-time
Operating lease liabilities	`OperatingLeaseLiabilityCurrent`	$10.83M	USD	Point-in-time
Financing lease liabilities	`FinanceLeaseLiabilityCurrent`	$331.00K	USD	Point-in-time
Financing lease liabilities	`FinanceLeaseLiabilityCurrent`	-	USD	Point-in-time
Total current liabilities	`LiabilitiesCurrent`	$59.83M	USD	Point-in-time
Total current liabilities	`LiabilitiesCurrent`	$62.63M	USD	Point-in-time
Operating lease liabilities, net of current portion	`OperatingLeaseLiabilityNoncurrent`	$85.66M	USD	Point-in-time
Operating lease liabilities, net of current portion	`OperatingLeaseLiabilityNoncurrent`	$72.00M	USD	Point-in-time
Financing lease liabilities, net of current portion	`FinanceLeaseLiabilityNoncurrent`	-	USD	Point-in-time
Financing lease liabilities, net of current portion	`FinanceLeaseLiabilityNoncurrent`	$276.00K	USD	Point-in-time
Other non-current liabilities	`OtherLiabilitiesNoncurrent`	-	USD	Point-in-time
Other non-current liabilities	`OtherLiabilitiesNoncurrent`	$3.28M	USD	Point-in-time
Total liabilities	`Liabilities`	$145.76M	USD	Point-in-time
Total liabilities	`Liabilities`	$137.90M	USD	Point-in-time
Commitments and contingent liabilities (Note 16)	`CommitmentsAndContingencies`	-	USD	Point-in-time
Commitments and contingent liabilities (Note 16)	`CommitmentsAndContingencies`	-	USD	Point-in-time
Preferred stock, $0.001 par value; 25,000,000 shares authorized, no shares issued and outstanding at December 31, 2022 and 2021	`PreferredStockValueOutstanding`	-	USD	Point-in-time
Preferred stock, $0.001 par value; 25,000,000 shares authorized, no shares issued and outstanding at December 31, 2022 and 2021	`PreferredStockValueOutstanding`	-	USD	Point-in-time
Common stock, $0.001 par value; 125,000,000 shares authorized; 71,256,118 shares issued and 55,039,707 outstanding at December 31, 2022 and 70,550,631 shares issued and 54,334,220 outstanding at December 31, 2021	`CommonStockValueOutstanding`	$71.00K	USD	Point-in-time
Common stock, $0.001 par value; 125,000,000 shares authorized; 71,256,118 shares issued and 55,039,707 outstanding at December 31, 2022 and 70,550,631 shares issued and 54,334,220 outstanding at December 31, 2021	`CommonStockValueOutstanding`	$71.00K	USD	Point-in-time
Additional paid-in capital	`AdditionalPaidInCapitalCommonStock`	$2.39B	USD	Point-in-time
Additional paid-in capital	`AdditionalPaidInCapitalCommonStock`	$2.33B	USD	Point-in-time
Accumulated other comprehensive loss	`AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax`	$-12.54M	USD	Point-in-time
Accumulated other comprehensive loss	`AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax`	$-1.20M	USD	Point-in-time
Accumulated deficit	`RetainedEarningsAccumulatedDeficit`	$-238.76M	USD	Point-in-time
Accumulated deficit	`RetainedEarningsAccumulatedDeficit`	$-470.56M	USD	Point-in-time
Treasury stock, at cost (16,216,411 shares at December 31, 2022 and December 31, 2021)	`TreasuryStockValue`	$802.49M	USD	Point-in-time
Treasury stock, at cost (16,216,411 shares at December 31, 2022 and December 31, 2021)	`TreasuryStockValue`	$802.49M	USD	Point-in-time
Total stockholders equity	`StockholdersEquity`	$1.29B	USD	Point-in-time
Total stockholders equity	`StockholdersEquity`	$399.50M	USD	Point-in-time
Total stockholders equity	`StockholdersEquity`	$1.10B	USD	Point-in-time
Total stockholders equity	`StockholdersEquity`	$640.53M	USD	Point-in-time
Total liabilities and stockholders equity	`LiabilitiesAndStockholdersEquity`	$1.24B	USD	Point-in-time
Total liabilities and stockholders equity	`LiabilitiesAndStockholdersEquity`	$1.44B	USD	Point-in-time

Income Statement 63 line items

Line Item	Tag	Value	Unit	Period
Total revenue	`RevenueFromContractWithCustomerExcludingAssessedTax`	-	USD	Annual
Total revenue	`RevenueFromContractWithCustomerExcludingAssessedTax`	$14.24M	USD	Annual
Total revenue	`RevenueFromContractWithCustomerExcludingAssessedTax`	-	USD	Annual
Cost of sales	`CostOfGoodsAndServicesSold`	-	USD	Annual
Cost of sales	`CostOfGoodsAndServicesSold`	-	USD	Annual
Cost of sales	`CostOfGoodsAndServicesSold`	$1.70M	USD	Annual
Research and development	`ResearchAndDevelopmentExpense`	$220.81M	USD	Annual
Research and development	`ResearchAndDevelopmentExpense`	$256.97M	USD	Annual
Research and development	`ResearchAndDevelopmentExpense`	$279.91M	USD	Annual
Selling, general and administrative	`SellingGeneralAndAdministrativeExpense`	$121.67M	USD	Annual
Selling, general and administrative	`SellingGeneralAndAdministrativeExpense`	$115.11M	USD	Annual
Selling, general and administrative	`SellingGeneralAndAdministrativeExpense`	$121.44M	USD	Annual
Total operating expenses	`CostsAndExpenses`	$335.92M	USD	Annual
Total operating expenses	`CostsAndExpenses`	$378.42M	USD	Annual
Total operating expenses	`CostsAndExpenses`	$403.29M	USD	Annual
Loss from operations	`OperatingIncomeLoss`	$-389.05M	USD	Annual
Loss from operations	`OperatingIncomeLoss`	$-378.42M	USD	Annual
Loss from operations	`OperatingIncomeLoss`	$-335.92M	USD	Annual
Gain on sale of contingent payments	`GainLossOnSaleOfContingentPayments`	-	USD	Annual
Gain on sale of contingent payments	`GainLossOnSaleOfContingentPayments`	$127.85M	USD	Annual
Gain on sale of contingent payments	`GainLossOnSaleOfContingentPayments`	-	USD	Annual
Royalty income from gain on sale of oncology business	`RoyaltyIncomeNonoperating`	$9.85M	USD	Annual
Royalty income from gain on sale of oncology business	`RoyaltyIncomeNonoperating`	-	USD	Annual
Royalty income from gain on sale of oncology business	`RoyaltyIncomeNonoperating`	$6.64M	USD	Annual
Interest income, net	`InvestmentIncomeInterest`	$836.00K	USD	Annual
Interest income, net	`InvestmentIncomeInterest`	$12.79M	USD	Annual
Interest income, net	`InvestmentIncomeInterest`	$6.61M	USD	Annual
Other income, net	`OtherNonoperatingIncomeExpense`	-	USD	Annual
Other income, net	`OtherNonoperatingIncomeExpense`	$14.43M	USD	Annual
Other income, net	`OtherNonoperatingIncomeExpense`	$6.75M	USD	Annual
Net loss from continuing operations	`IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest`	$-329.31M	USD	Annual
Net loss from continuing operations	`IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest`	$-356.51M	USD	Annual
Net loss from continuing operations	`IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest`	$-231.80M	USD	Annual
Net income from discontinued operations, net of tax	`IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity`	$1.96B	USD	Annual
Net income from discontinued operations, net of tax	`IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity`	$1.94M	USD	Annual
Net income from discontinued operations, net of tax	`IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity`	-	USD	Annual
Net (loss) income	`NetIncomeLoss`	$-327.37M	USD	Annual
Net (loss) income	`NetIncomeLoss`	$1.60B	USD	Annual
Net (loss) income	`NetIncomeLoss`	$-231.80M	USD	Annual
Net loss from continuing operations per share - basic (in usd per share)	`IncomeLossFromContinuingOperationsPerBasicShare`	$-4.23	USD	Annual
Net loss from continuing operations per share - basic (in usd per share)	`IncomeLossFromContinuingOperationsPerBasicShare`	$-5.90	USD	Annual
Net loss from continuing operations per share - basic (in usd per share)	`IncomeLossFromContinuingOperationsPerBasicShare`	$-4.77	USD	Annual
Net loss from continuing operations per share - diluted (in usd per share)	`IncomeLossFromContinuingOperationsPerDilutedShare`	$-5.90	USD	Annual
Net loss from continuing operations per share - diluted (in usd per share)	`IncomeLossFromContinuingOperationsPerDilutedShare`	$-4.77	USD	Annual
Net loss from continuing operations per share - diluted (in usd per share)	`IncomeLossFromContinuingOperationsPerDilutedShare`	$-4.23	USD	Annual
Net income from discontinued operations per share - basic (in usd per share)	`IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare`	-	USD	Annual
Net income from discontinued operations per share - basic (in usd per share)	`IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare`	$32.45	USD	Annual
Net income from discontinued operations per share - basic (in usd per share)	`IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare`	$0.03	USD	Annual
Net income from discontinued operations per share - diluted (in usd per share)	`IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare`	$0.03	USD	Annual
Net income from discontinued operations per share - diluted (in usd per share)	`IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare`	-	USD	Annual
Net income from discontinued operations per share - diluted (in usd per share)	`IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare`	$32.45	USD	Annual
Net income (loss) per share basic (in usd per share)	`EarningsPerShareBasic`	$-4.23	USD	Annual
Net income (loss) per share basic (in usd per share)	`EarningsPerShareBasic`	$-4.74	USD	Annual
Net income (loss) per share basic (in usd per share)	`EarningsPerShareBasic`	$26.55	USD	Annual
Net income (loss) per share diluted (in usd per share)	`EarningsPerShareDiluted`	$26.55	USD	Annual
Net income (loss) per share diluted (in usd per share)	`EarningsPerShareDiluted`	$-4.74	USD	Annual
Net income (loss) per share diluted (in usd per share)	`EarningsPerShareDiluted`	$-4.23	USD	Annual
Weighted-average number of common shares used in computing net loss per share basic (in shares)	`WeightedAverageNumberOfSharesOutstandingBasic`	69.00M	shares	Annual
Weighted-average number of common shares used in computing net loss per share basic (in shares)	`WeightedAverageNumberOfSharesOutstandingBasic`	54.79M	shares	Annual
Weighted-average number of common shares used in computing net loss per share basic (in shares)	`WeightedAverageNumberOfSharesOutstandingBasic`	60.45M	shares	Annual
Weighted-average number of common shares used in computing net loss per share diluted (in shares)	`WeightedAverageNumberOfDilutedSharesOutstanding`	60.45M	shares	Annual
Weighted-average number of common shares used in computing net loss per share diluted (in shares)	`WeightedAverageNumberOfDilutedSharesOutstanding`	54.79M	shares	Annual
Weighted-average number of common shares used in computing net loss per share diluted (in shares)	`WeightedAverageNumberOfDilutedSharesOutstanding`	69.00M	shares	Annual

Cash Flow Statement 122 line items

Line Item	Tag	Value	Unit	Period
Net (loss) income	`NetIncomeLoss`	$-327.37M	USD	Annual
Net (loss) income	`NetIncomeLoss`	$1.60B	USD	Annual
Net (loss) income	`NetIncomeLoss`	$-231.80M	USD	Annual
Less: Net income from discontinued operations	`IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity`	$1.96B	USD	Annual
Less: Net income from discontinued operations	`IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity`	$1.94M	USD	Annual
Less: Net income from discontinued operations	`IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity`	-	USD	Annual
Net loss from continuing operations	`IncomeLossFromContinuingOperations`	$-329.31M	USD	Annual
Net loss from continuing operations	`IncomeLossFromContinuingOperations`	$-231.80M	USD	Annual
Net loss from continuing operations	`IncomeLossFromContinuingOperations`	$-356.51M	USD	Annual
Depreciation and amortization	`OtherDepreciationAndAmortization`	$9.79M	USD	Annual
Depreciation and amortization	`OtherDepreciationAndAmortization`	$8.56M	USD	Annual
Depreciation and amortization	`OtherDepreciationAndAmortization`	$9.24M	USD	Annual
Stock-based compensation expense	`ShareBasedCompensation`	$53.51M	USD	Annual
Stock-based compensation expense	`ShareBasedCompensation`	$61.60M	USD	Annual
Stock-based compensation expense	`ShareBasedCompensation`	$49.30M	USD	Annual
Net (accretion of discount) amortization of premium on marketable securities	`AccretionAmortizationOfDiscountsAndPremiumsInvestments`	$-3.02M	USD	Annual
Net (accretion of discount) amortization of premium on marketable securities	`AccretionAmortizationOfDiscountsAndPremiumsInvestments`	$-6.95M	USD	Annual
Net (accretion of discount) amortization of premium on marketable securities	`AccretionAmortizationOfDiscountsAndPremiumsInvestments`	$1.20M	USD	Annual
Gain on sale of contingent payments	`GainLossOnSaleOfContingentPayments`	-	USD	Annual
Gain on sale of contingent payments	`GainLossOnSaleOfContingentPayments`	$127.85M	USD	Annual
Gain on sale of contingent payments	`GainLossOnSaleOfContingentPayments`	-	USD	Annual
(Gain) loss on disposal of property and equipment	`GainLossOnSaleOfPropertyPlantEquipment`	-	USD	Annual
(Gain) loss on disposal of property and equipment	`GainLossOnSaleOfPropertyPlantEquipment`	$-12.00K	USD	Annual
(Gain) loss on disposal of property and equipment	`GainLossOnSaleOfPropertyPlantEquipment`	$48.00K	USD	Annual
Non-cash operating lease expense	`OperatingLeaseRightOfUseAssetAmortizationExpense`	$9.99M	USD	Annual
Non-cash operating lease expense	`OperatingLeaseRightOfUseAssetAmortizationExpense`	$9.54M	USD	Annual
Non-cash operating lease expense	`OperatingLeaseRightOfUseAssetAmortizationExpense`	$8.98M	USD	Annual
Accounts receivable, net	`IncreaseDecreaseInAccountsReceivable`	$2.21M	USD	Annual
Accounts receivable, net	`IncreaseDecreaseInAccountsReceivable`	-	USD	Annual
Accounts receivable, net	`IncreaseDecreaseInAccountsReceivable`	-	USD	Annual
Inventory	`IncreaseDecreaseInInventories`	-	USD	Annual
Inventory	`IncreaseDecreaseInInventories`	$8.49M	USD	Annual
Inventory	`IncreaseDecreaseInInventories`	-	USD	Annual
Other receivables	`IncreaseDecreaseInContractWithCustomerAsset`	-	USD	Annual
Other receivables	`IncreaseDecreaseInContractWithCustomerAsset`	$4.38M	USD	Annual
Other receivables	`IncreaseDecreaseInContractWithCustomerAsset`	$-447.00K	USD	Annual
Prepaid expenses and other current and non-current assets	`IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets`	$176.00K	USD	Annual
Prepaid expenses and other current and non-current assets	`IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets`	$3.00K	USD	Annual
Prepaid expenses and other current and non-current assets	`IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets`	$26.85M	USD	Annual
Accounts payable	`IncreaseDecreaseInAccountsPayable`	$3.44M	USD	Annual
Accounts payable	`IncreaseDecreaseInAccountsPayable`	$1.86M	USD	Annual
Accounts payable	`IncreaseDecreaseInAccountsPayable`	$3.33M	USD	Annual
Accrued expenses	`IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities`	$6.76M	USD	Annual
Accrued expenses	`IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities`	$-1.62M	USD	Annual
Accrued expenses	`IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities`	$66.00K	USD	Annual
Operating lease liabilities	`IncreaseDecreaseInOperatingLeaseLiability`	$-8.13M	USD	Annual
Operating lease liabilities	`IncreaseDecreaseInOperatingLeaseLiability`	$-10.83M	USD	Annual
Operating lease liabilities	`IncreaseDecreaseInOperatingLeaseLiability`	$-7.53M	USD	Annual
Other liabilities	`IncreaseDecreaseInOtherOperatingLiabilities`	$3.00M	USD	Annual
Other liabilities	`IncreaseDecreaseInOtherOperatingLiabilities`	-	USD	Annual
Other liabilities	`IncreaseDecreaseInOtherOperatingLiabilities`	-	USD	Annual
Net cash used in operating activities	`NetCashProvidedByUsedInOperatingActivitiesContinuingOperations`	$-314.09M	USD	Annual
Net cash used in operating activities	`NetCashProvidedByUsedInOperatingActivitiesContinuingOperations`	$-309.48M	USD	Annual
Net cash used in operating activities	`NetCashProvidedByUsedInOperatingActivitiesContinuingOperations`	$-243.94M	USD	Annual
Net cash used in operating activities - discontinued operations	`CashProvidedByUsedInOperatingActivitiesDiscontinuedOperations`	$-93.23M	USD	Annual
Net cash used in operating activities - discontinued operations	`CashProvidedByUsedInOperatingActivitiesDiscontinuedOperations`	$-46.81M	USD	Annual
Net cash used in operating activities - discontinued operations	`CashProvidedByUsedInOperatingActivitiesDiscontinuedOperations`	-	USD	Annual
Net cash used in operating activities	`NetCashProvidedByUsedInOperatingActivities`	$-309.48M	USD	Annual
Net cash used in operating activities	`NetCashProvidedByUsedInOperatingActivities`	$-407.32M	USD	Annual
Net cash used in operating activities	`NetCashProvidedByUsedInOperatingActivities`	$-290.76M	USD	Annual
Purchases of marketable securities	`PaymentsToAcquireAvailableForSaleSecuritiesDebt`	$557.03M	USD	Annual
Purchases of marketable securities	`PaymentsToAcquireAvailableForSaleSecuritiesDebt`	$1.03B	USD	Annual
Purchases of marketable securities	`PaymentsToAcquireAvailableForSaleSecuritiesDebt`	$1.38B	USD	Annual
Proceeds from maturities and sales of marketable securities	`ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities`	$829.80M	USD	Annual
Proceeds from maturities and sales of marketable securities	`ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities`	$1.15B	USD	Annual
Proceeds from maturities and sales of marketable securities	`ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities`	$647.68M	USD	Annual
Proceeds from sale of contingent payments	`ProceedsFromSaleOfContingentPayments`	-	USD	Annual
Proceeds from sale of contingent payments	`ProceedsFromSaleOfContingentPayments`	$131.78M	USD	Annual
Proceeds from sale of contingent payments	`ProceedsFromSaleOfContingentPayments`	-	USD	Annual
Purchases of property and equipment	`PaymentsToAcquirePropertyPlantAndEquipment`	$14.11M	USD	Annual
Purchases of property and equipment	`PaymentsToAcquirePropertyPlantAndEquipment`	$5.74M	USD	Annual
Purchases of property and equipment	`PaymentsToAcquirePropertyPlantAndEquipment`	$4.88M	USD	Annual
Proceeds from sale of equipment	`ProceedsFromSaleOfMachineryAndEquipment`	-	USD	Annual
Proceeds from sale of equipment	`ProceedsFromSaleOfMachineryAndEquipment`	-	USD	Annual
Proceeds from sale of equipment	`ProceedsFromSaleOfMachineryAndEquipment`	$964.00K	USD	Annual
Net cash provided by (used in) investing activities	`NetCashProvidedByUsedInInvestingActivitiesContinuingOperations`	$76.55M	USD	Annual
Net cash provided by (used in) investing activities	`NetCashProvidedByUsedInInvestingActivitiesContinuingOperations`	$-554.16M	USD	Annual
Net cash provided by (used in) investing activities	`NetCashProvidedByUsedInInvestingActivitiesContinuingOperations`	$243.26M	USD	Annual
Net cash provided by (used in) investing activities - discontinued operations	`CashProvidedByUsedInInvestingActivitiesDiscontinuedOperations`	$1.80B	USD	Annual
Net cash provided by (used in) investing activities - discontinued operations	`CashProvidedByUsedInInvestingActivitiesDiscontinuedOperations`	$-803.00K	USD	Annual
Net cash provided by (used in) investing activities - discontinued operations	`CashProvidedByUsedInInvestingActivitiesDiscontinuedOperations`	-	USD	Annual
Net cash provided by investing activities	`NetCashProvidedByUsedInInvestingActivities`	$243.26M	USD	Annual
Net cash provided by investing activities	`NetCashProvidedByUsedInInvestingActivities`	$75.75M	USD	Annual
Net cash provided by investing activities	`NetCashProvidedByUsedInInvestingActivities`	$1.25B	USD	Annual
Payments on financing lease obligations	`FinanceLeasePrincipalPayments`	$336.00K	USD	Annual
Payments on financing lease obligations	`FinanceLeasePrincipalPayments`	$578.00K	USD	Annual
Payments on financing lease obligations	`FinanceLeasePrincipalPayments`	$331.00K	USD	Annual
Purchase of treasury stock	`PaymentsForRepurchaseOfEquity`	$802.49M	USD	Annual
Purchase of treasury stock	`PaymentsForRepurchaseOfEquity`	-	USD	Annual
Purchase of treasury stock	`PaymentsForRepurchaseOfEquity`	-	USD	Annual
Net proceeds from stock option exercises and employee stock purchase plan	`ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions`	$2.68M	USD	Annual
Net proceeds from stock option exercises and employee stock purchase plan	`ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions`	$37.30M	USD	Annual
Net proceeds from stock option exercises and employee stock purchase plan	`ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions`	$11.32M	USD	Annual
Net cash provided by (used in) financing activities	`NetCashProvidedByUsedInFinancingActivitiesContinuingOperations`	$2.35M	USD	Annual
Net cash provided by (used in) financing activities	`NetCashProvidedByUsedInFinancingActivitiesContinuingOperations`	$10.98M	USD	Annual
Net cash provided by (used in) financing activities	`NetCashProvidedByUsedInFinancingActivitiesContinuingOperations`	$-765.77M	USD	Annual
Net cash provided by financing activities - discontinued operations	`CashProvidedByUsedInFinancingActivitiesDiscontinuedOperations`	-	USD	Annual
Net cash provided by financing activities - discontinued operations	`CashProvidedByUsedInFinancingActivitiesDiscontinuedOperations`	-	USD	Annual
Net cash provided by financing activities - discontinued operations	`CashProvidedByUsedInFinancingActivitiesDiscontinuedOperations`	$250.54M	USD	Annual
Net cash provided by (used in) financing activities	`NetCashProvidedByUsedInFinancingActivities`	$2.35M	USD	Annual
Net cash provided by (used in) financing activities	`NetCashProvidedByUsedInFinancingActivities`	$-765.77M	USD	Annual
Net cash provided by (used in) financing activities	`NetCashProvidedByUsedInFinancingActivities`	$261.52M	USD	Annual
Net change in cash and cash equivalents	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect`	$-63.87M	USD	Annual
Net change in cash and cash equivalents	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect`	$75.69M	USD	Annual
Net change in cash and cash equivalents	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect`	$46.51M	USD	Annual
Cash and cash equivalents at beginning of the period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$80.93M	USD	Point-in-time
Cash and cash equivalents at beginning of the period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$203.13M	USD	Point-in-time
Cash and cash equivalents at beginning of the period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$139.26M	USD	Point-in-time
Cash and cash equivalents at beginning of the period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$127.44M	USD	Point-in-time
Cash and cash equivalents at end of the period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$80.93M	USD	Point-in-time
Cash and cash equivalents at end of the period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$203.13M	USD	Point-in-time
Cash and cash equivalents at end of the period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$139.26M	USD	Point-in-time
Cash and cash equivalents at end of the period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$127.44M	USD	Point-in-time
Additions to property and equipment in accounts payable and accrued expenses	`CapitalExpendituresIncurredButNotYetPaid`	$158.00K	USD	Annual
Additions to property and equipment in accounts payable and accrued expenses	`CapitalExpendituresIncurredButNotYetPaid`	$1.68M	USD	Annual
Additions to property and equipment in accounts payable and accrued expenses	`CapitalExpendituresIncurredButNotYetPaid`	$465.00K	USD	Annual
Cash taxes paid	`IncomeTaxesPaid`	-	USD	Annual
Cash taxes paid	`IncomeTaxesPaid`	$16.08M	USD	Annual
Cash taxes paid	`IncomeTaxesPaid`	-	USD	Annual
Financing lease liabilities arising from obtaining financing lease assets	`RightOfUseAssetObtainedInExchangeForFinanceLeaseLiability`	$511.00K	USD	Annual
Financing lease liabilities arising from obtaining financing lease assets	`RightOfUseAssetObtainedInExchangeForFinanceLeaseLiability`	-	USD	Annual
Financing lease liabilities arising from obtaining financing lease assets	`RightOfUseAssetObtainedInExchangeForFinanceLeaseLiability`	-	USD	Annual

Stockholders Equity 28 line items

Line Item	Tag	Value	Unit	Period
Common stock, beginning balance (in shares)	`CommonStockSharesOutstanding`	55.04M	shares	Point-in-time
Common stock, beginning balance (in shares)	`CommonStockSharesOutstanding`	54.33M	shares	Point-in-time
Beginning balance	`StockholdersEquity`	$1.29B	USD	Point-in-time
Beginning balance	`StockholdersEquity`	$399.50M	USD	Point-in-time
Beginning balance	`StockholdersEquity`	$1.10B	USD	Point-in-time
Beginning balance	`StockholdersEquity`	$640.53M	USD	Point-in-time
Unrealized gain (loss) on available-for-sale securities	`OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax`	$-11.34M	USD	Annual
Unrealized gain (loss) on available-for-sale securities	`OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax`	$-97.00K	USD	Annual
Unrealized gain (loss) on available-for-sale securities	`OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax`	$-1.30M	USD	Annual
Net (loss) income	`NetIncomeLoss`	$-327.37M	USD	Annual
Net (loss) income	`NetIncomeLoss`	$1.60B	USD	Annual
Net (loss) income	`NetIncomeLoss`	$-231.80M	USD	Annual
Stock-based compensation expense	`AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue`	$49.30M	USD	Annual
Stock-based compensation expense	`AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue`	$61.60M	USD	Annual
Stock-based compensation expense	`AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue`	$53.51M	USD	Annual
Issuance of common stock under stock incentive and employee stock purchase plans (in shares)	`StockIssuedDuringPeriodSharesStockOptionsExercised`	15,539.00	shares	Annual
Issuance of common stock under stock incentive and employee stock purchase plans	`StockIssuedDuringPeriodValueStockOptionsExercised`	$37.30M	USD	Annual
Issuance of common stock under stock incentive and employee stock purchase plans	`StockIssuedDuringPeriodValueStockOptionsExercised`	$11.32M	USD	Annual
Issuance of common stock under stock incentive and employee stock purchase plans	`StockIssuedDuringPeriodValueStockOptionsExercised`	$2.68M	USD	Annual
Repurchase of common stock	`TreasuryStockValueAcquiredCostMethod`	$802.49M	USD	Annual
Disposition of oncology business	`StockholdersEquityDispositionOfBusiness`	$-745.00K	USD	Annual
Disposition of oncology business	`StockholdersEquityDispositionOfBusiness`	$-13.52M	USD	Annual
Common stock, ending balance (in shares)	`CommonStockSharesOutstanding`	55.04M	shares	Point-in-time
Common stock, ending balance (in shares)	`CommonStockSharesOutstanding`	54.33M	shares	Point-in-time
Ending balance	`StockholdersEquity`	$1.29B	USD	Point-in-time
Ending balance	`StockholdersEquity`	$399.50M	USD	Point-in-time
Ending balance	`StockholdersEquity`	$1.10B	USD	Point-in-time
Ending balance	`StockholdersEquity`	$640.53M	USD	Point-in-time

Comprehensive Income 9 line items

Line Item	Tag	Value	Unit	Period
Net (loss) income	`NetIncomeLoss`	$-327.37M	USD	Annual
Net (loss) income	`NetIncomeLoss`	$1.60B	USD	Annual
Net (loss) income	`NetIncomeLoss`	$-231.80M	USD	Annual
Unrealized loss on available-for-sale securities	`OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax`	$-11.34M	USD	Annual
Unrealized loss on available-for-sale securities	`OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax`	$-97.00K	USD	Annual
Unrealized loss on available-for-sale securities	`OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax`	$-1.30M	USD	Annual
Comprehensive (loss) income	`ComprehensiveIncomeNetOfTax`	$1.60B	USD	Annual
Comprehensive (loss) income	`ComprehensiveIncomeNetOfTax`	$-327.47M	USD	Annual
Comprehensive (loss) income	`ComprehensiveIncomeNetOfTax`	$-243.14M	USD	Annual

Data is extracted from SEC EDGAR XBRL filings. Values shown are as reported in the filing.