10-K Filing

AGIOS PHARMACEUTICALS, INC. CIK: 1439222 FY 2024

Filing Information

Form Type	10-K
Accession Number	`0001439222-25-000009`
Period End Date	20241231
Filing Date	20250213
Fiscal Year	2024
Fiscal Period	FY
XBRL Instance	agio-20241231_htm.xml

Filing Contents

This filing contains the following financial statements:

Balance Sheet 152 Income Statement 108 Cash Flow Statement 220 Stockholders Equity 58 Comprehensive Income 18

Balance Sheet 152 line items

Line Item	Tag	Value	Unit	Period
Preferred stock, par value (in usd per share)	`PreferredStockParOrStatedValuePerShare`	$0.00	USD	Point-in-time
Preferred stock, par value (in usd per share)	`PreferredStockParOrStatedValuePerShare`	$0.00	USD	Point-in-time
Preferred stock, par value (in usd per share)	`PreferredStockParOrStatedValuePerShare`	$0.00	USD	Point-in-time
Preferred stock, par value (in usd per share)	`PreferredStockParOrStatedValuePerShare`	$0.00	USD	Point-in-time
Preferred stock, authorized (in shares)	`PreferredStockSharesAuthorized`	25.00M	shares	Point-in-time
Preferred stock, authorized (in shares)	`PreferredStockSharesAuthorized`	25.00M	shares	Point-in-time
Preferred stock, authorized (in shares)	`PreferredStockSharesAuthorized`	25.00M	shares	Point-in-time
Preferred stock, authorized (in shares)	`PreferredStockSharesAuthorized`	25.00M	shares	Point-in-time
Preferred stock, issued (in shares)	`PreferredStockSharesIssued`	0.00	shares	Point-in-time
Preferred stock, issued (in shares)	`PreferredStockSharesIssued`	0.00	shares	Point-in-time
Cash and cash equivalents	`CashAndCashEquivalentsAtCarryingValue`	$76.25M	USD	Point-in-time
Cash and cash equivalents	`CashAndCashEquivalentsAtCarryingValue`	$76.25M	USD	Point-in-time
Cash and cash equivalents	`CashAndCashEquivalentsAtCarryingValue`	$88.20M	USD	Point-in-time
Cash and cash equivalents	`CashAndCashEquivalentsAtCarryingValue`	$88.20M	USD	Point-in-time
Preferred stock, issued (in shares)	`PreferredStockSharesIssued`	0.00	shares	Point-in-time
Preferred stock, issued (in shares)	`PreferredStockSharesIssued`	0.00	shares	Point-in-time
Preferred stock, outstanding (in shares)	`PreferredStockSharesOutstanding`	0.00	shares	Point-in-time
Preferred stock, outstanding (in shares)	`PreferredStockSharesOutstanding`	0.00	shares	Point-in-time
Marketable securities	`AvailableForSaleSecuritiesDebtSecuritiesCurrent`	$688.72M	USD	Point-in-time
Marketable securities	`AvailableForSaleSecuritiesDebtSecuritiesCurrent`	$688.72M	USD	Point-in-time
Marketable securities	`AvailableForSaleSecuritiesDebtSecuritiesCurrent`	$817.46M	USD	Point-in-time
Marketable securities	`AvailableForSaleSecuritiesDebtSecuritiesCurrent`	$817.46M	USD	Point-in-time
Preferred stock, outstanding (in shares)	`PreferredStockSharesOutstanding`	0.00	shares	Point-in-time
Preferred stock, outstanding (in shares)	`PreferredStockSharesOutstanding`	0.00	shares	Point-in-time
Accounts receivable, net	`ContractWithCustomerAssetNetCurrent`	$4.11M	USD	Point-in-time
Accounts receivable, net	`ContractWithCustomerAssetNetCurrent`	$4.11M	USD	Point-in-time
Accounts receivable, net	`ContractWithCustomerAssetNetCurrent`	$2.81M	USD	Point-in-time
Accounts receivable, net	`ContractWithCustomerAssetNetCurrent`	$2.81M	USD	Point-in-time
Common stock, par value (in usd per share)	`CommonStockParOrStatedValuePerShare`	$0.00	USD	Point-in-time
Common stock, par value (in usd per share)	`CommonStockParOrStatedValuePerShare`	$0.00	USD	Point-in-time
Common stock, par value (in usd per share)	`CommonStockParOrStatedValuePerShare`	$0.00	USD	Point-in-time
Common stock, par value (in usd per share)	`CommonStockParOrStatedValuePerShare`	$0.00	USD	Point-in-time
Inventory	`InventoryNet`	$27.62M	USD	Point-in-time
Inventory	`InventoryNet`	$27.62M	USD	Point-in-time
Common stock, authorized (in shares)	`CommonStockSharesAuthorized`	125.00M	shares	Point-in-time
Common stock, authorized (in shares)	`CommonStockSharesAuthorized`	125.00M	shares	Point-in-time
Inventory	`InventoryNet`	$19.08M	USD	Point-in-time
Inventory	`InventoryNet`	$19.08M	USD	Point-in-time
Common stock, authorized (in shares)	`CommonStockSharesAuthorized`	125.00M	shares	Point-in-time
Common stock, authorized (in shares)	`CommonStockSharesAuthorized`	125.00M	shares	Point-in-time
Common stock, issued (in shares)	`CommonStockSharesIssued`	72.16M	shares	Point-in-time
Common stock, issued (in shares)	`CommonStockSharesIssued`	72.16M	shares	Point-in-time
Prepaid expenses and other current assets	`PrepaidExpenseAndOtherAssetsCurrent`	$35.02M	USD	Point-in-time
Prepaid expenses and other current assets	`PrepaidExpenseAndOtherAssetsCurrent`	$35.02M	USD	Point-in-time
Prepaid expenses and other current assets	`PrepaidExpenseAndOtherAssetsCurrent`	$40.16M	USD	Point-in-time
Prepaid expenses and other current assets	`PrepaidExpenseAndOtherAssetsCurrent`	$40.16M	USD	Point-in-time
Common stock, issued (in shares)	`CommonStockSharesIssued`	73.37M	shares	Point-in-time
Common stock, issued (in shares)	`CommonStockSharesIssued`	73.37M	shares	Point-in-time
Total current assets	`AssetsCurrent`	$965.60M	USD	Point-in-time
Total current assets	`AssetsCurrent`	$965.60M	USD	Point-in-time
Total current assets	`AssetsCurrent`	$833.84M	USD	Point-in-time
Total current assets	`AssetsCurrent`	$833.84M	USD	Point-in-time
Common stock, outstanding (in shares)	`CommonStockSharesOutstanding`	57.16M	shares	Point-in-time
Common stock, outstanding (in shares)	`CommonStockSharesOutstanding`	57.16M	shares	Point-in-time
Common stock, outstanding (in shares)	`CommonStockSharesOutstanding`	55.95M	shares	Point-in-time
Common stock, outstanding (in shares)	`CommonStockSharesOutstanding`	55.95M	shares	Point-in-time
Treasury stock (in shares)	`TreasuryStockCommonShares`	16.22M	shares	Point-in-time
Treasury stock (in shares)	`TreasuryStockCommonShares`	16.22M	shares	Point-in-time
Marketable securities	`AvailableForSaleSecuritiesDebtSecuritiesNoncurrent`	$29.43M	USD	Point-in-time
Marketable securities	`AvailableForSaleSecuritiesDebtSecuritiesNoncurrent`	$29.43M	USD	Point-in-time
Treasury stock (in shares)	`TreasuryStockCommonShares`	16.22M	shares	Point-in-time
Treasury stock (in shares)	`TreasuryStockCommonShares`	16.22M	shares	Point-in-time
Marketable securities	`AvailableForSaleSecuritiesDebtSecuritiesNoncurrent`	$638.32M	USD	Point-in-time
Marketable securities	`AvailableForSaleSecuritiesDebtSecuritiesNoncurrent`	$638.32M	USD	Point-in-time
Operating lease assets	`OperatingLeaseRightOfUseAsset`	$42.88M	USD	Point-in-time
Operating lease assets	`OperatingLeaseRightOfUseAsset`	$42.88M	USD	Point-in-time
Operating lease assets	`OperatingLeaseRightOfUseAsset`	$54.41M	USD	Point-in-time
Operating lease assets	`OperatingLeaseRightOfUseAsset`	$54.41M	USD	Point-in-time
Property and equipment, net	`PropertyPlantAndEquipmentNet`	$15.38M	USD	Point-in-time
Property and equipment, net	`PropertyPlantAndEquipmentNet`	$15.38M	USD	Point-in-time
Property and equipment, net	`PropertyPlantAndEquipmentNet`	$11.68M	USD	Point-in-time
Property and equipment, net	`PropertyPlantAndEquipmentNet`	$11.68M	USD	Point-in-time
Other non-current assets	`OtherAssetsNoncurrent`	$4.72M	USD	Point-in-time
Other non-current assets	`OtherAssetsNoncurrent`	$4.72M	USD	Point-in-time
Other non-current assets	`OtherAssetsNoncurrent`	$4.06M	USD	Point-in-time
Other non-current assets	`OtherAssetsNoncurrent`	$4.06M	USD	Point-in-time
Total assets	`Assets`	$1.66B	USD	Point-in-time
Total assets	`Assets`	$1.66B	USD	Point-in-time
Total assets	`Assets`	$937.12M	USD	Point-in-time
Total assets	`Assets`	$937.12M	USD	Point-in-time
Accounts payable	`AccountsPayableCurrent`	$16.64M	USD	Point-in-time
Accounts payable	`AccountsPayableCurrent`	$16.64M	USD	Point-in-time
Accounts payable	`AccountsPayableCurrent`	$9.78M	USD	Point-in-time
Accounts payable	`AccountsPayableCurrent`	$9.78M	USD	Point-in-time
Accrued expenses	`AccruedLiabilitiesCurrent`	$46.86M	USD	Point-in-time
Accrued expenses	`AccruedLiabilitiesCurrent`	$46.86M	USD	Point-in-time
Accrued expenses	`AccruedLiabilitiesCurrent`	$43.17M	USD	Point-in-time
Accrued expenses	`AccruedLiabilitiesCurrent`	$43.17M	USD	Point-in-time
Income taxes payable	`TaxesPayableCurrent`	$871.00K	USD	Point-in-time
Income taxes payable	`TaxesPayableCurrent`	$871.00K	USD	Point-in-time
Income taxes payable	`TaxesPayableCurrent`	-	USD	Point-in-time
Income taxes payable	`TaxesPayableCurrent`	-	USD	Point-in-time
Operating lease liabilities	`OperatingLeaseLiabilityCurrent`	$15.01M	USD	Point-in-time
Operating lease liabilities	`OperatingLeaseLiabilityCurrent`	$15.01M	USD	Point-in-time
Operating lease liabilities	`OperatingLeaseLiabilityCurrent`	$16.78M	USD	Point-in-time
Operating lease liabilities	`OperatingLeaseLiabilityCurrent`	$16.78M	USD	Point-in-time
Total current liabilities	`LiabilitiesCurrent`	$67.95M	USD	Point-in-time
Total current liabilities	`LiabilitiesCurrent`	$67.95M	USD	Point-in-time
Total current liabilities	`LiabilitiesCurrent`	$81.16M	USD	Point-in-time
Total current liabilities	`LiabilitiesCurrent`	$81.16M	USD	Point-in-time
Operating lease liabilities, net of current portion	`OperatingLeaseLiabilityNoncurrent`	$56.99M	USD	Point-in-time
Operating lease liabilities, net of current portion	`OperatingLeaseLiabilityNoncurrent`	$56.99M	USD	Point-in-time
Operating lease liabilities, net of current portion	`OperatingLeaseLiabilityNoncurrent`	$40.21M	USD	Point-in-time
Operating lease liabilities, net of current portion	`OperatingLeaseLiabilityNoncurrent`	$40.21M	USD	Point-in-time
Other non-current liabilities	`OtherLiabilitiesNoncurrent`	$880.00K	USD	Point-in-time
Other non-current liabilities	`OtherLiabilitiesNoncurrent`	$880.00K	USD	Point-in-time
Other non-current liabilities	`OtherLiabilitiesNoncurrent`	$1.16M	USD	Point-in-time
Other non-current liabilities	`OtherLiabilitiesNoncurrent`	$1.16M	USD	Point-in-time
Total liabilities	`Liabilities`	$122.24M	USD	Point-in-time
Total liabilities	`Liabilities`	$122.24M	USD	Point-in-time
Total liabilities	`Liabilities`	$126.10M	USD	Point-in-time
Total liabilities	`Liabilities`	$126.10M	USD	Point-in-time
Commitments and contingent liabilities (Note 14)	`CommitmentsAndContingencies`	-	USD	Point-in-time
Commitments and contingent liabilities (Note 14)	`CommitmentsAndContingencies`	-	USD	Point-in-time
Commitments and contingent liabilities (Note 14)	`CommitmentsAndContingencies`	-	USD	Point-in-time
Commitments and contingent liabilities (Note 14)	`CommitmentsAndContingencies`	-	USD	Point-in-time
Preferred stock, $0.001 par value; 25,000,000 shares authorized, no shares issued and outstanding at December 31, 2024 and 2023	`PreferredStockValueOutstanding`	-	USD	Point-in-time
Preferred stock, $0.001 par value; 25,000,000 shares authorized, no shares issued and outstanding at December 31, 2024 and 2023	`PreferredStockValueOutstanding`	-	USD	Point-in-time
Preferred stock, $0.001 par value; 25,000,000 shares authorized, no shares issued and outstanding at December 31, 2024 and 2023	`PreferredStockValueOutstanding`	-	USD	Point-in-time
Preferred stock, $0.001 par value; 25,000,000 shares authorized, no shares issued and outstanding at December 31, 2024 and 2023	`PreferredStockValueOutstanding`	-	USD	Point-in-time
Common stock, $0.001 par value; 125,000,000 shares authorized; 73,372,696 shares issued and 57,156,285 outstanding at December 31, 2024 and 72,161,489 shares issued and 55,945,078 outstanding at December 31, 2023	`CommonStockValueOutstanding`	$72.00K	USD	Point-in-time
Common stock, $0.001 par value; 125,000,000 shares authorized; 73,372,696 shares issued and 57,156,285 outstanding at December 31, 2024 and 72,161,489 shares issued and 55,945,078 outstanding at December 31, 2023	`CommonStockValueOutstanding`	$72.00K	USD	Point-in-time
Common stock, $0.001 par value; 125,000,000 shares authorized; 73,372,696 shares issued and 57,156,285 outstanding at December 31, 2024 and 72,161,489 shares issued and 55,945,078 outstanding at December 31, 2023	`CommonStockValueOutstanding`	$73.00K	USD	Point-in-time
Common stock, $0.001 par value; 125,000,000 shares authorized; 73,372,696 shares issued and 57,156,285 outstanding at December 31, 2024 and 72,161,489 shares issued and 55,945,078 outstanding at December 31, 2023	`CommonStockValueOutstanding`	$73.00K	USD	Point-in-time
Additional paid-in capital	`AdditionalPaidInCapitalCommonStock`	$2.44B	USD	Point-in-time
Additional paid-in capital	`AdditionalPaidInCapitalCommonStock`	$2.44B	USD	Point-in-time
Additional paid-in capital	`AdditionalPaidInCapitalCommonStock`	$2.49B	USD	Point-in-time
Additional paid-in capital	`AdditionalPaidInCapitalCommonStock`	$2.49B	USD	Point-in-time
Accumulated other comprehensive loss	`AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax`	$-1.52M	USD	Point-in-time
Accumulated other comprehensive loss	`AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax`	$-1.52M	USD	Point-in-time
Accumulated other comprehensive loss	`AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax`	$-441.00K	USD	Point-in-time
Accumulated other comprehensive loss	`AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax`	$-441.00K	USD	Point-in-time
Accumulated deficit	`RetainedEarningsAccumulatedDeficit`	$-822.65M	USD	Point-in-time
Accumulated deficit	`RetainedEarningsAccumulatedDeficit`	$-822.65M	USD	Point-in-time
Accumulated deficit	`RetainedEarningsAccumulatedDeficit`	$-148.92M	USD	Point-in-time
Accumulated deficit	`RetainedEarningsAccumulatedDeficit`	$-148.92M	USD	Point-in-time
Treasury stock, at cost (16,216,411 shares at December 31, 2024 and December 31, 2023)	`TreasuryStockValue`	$802.49M	USD	Point-in-time
Treasury stock, at cost (16,216,411 shares at December 31, 2024 and December 31, 2023)	`TreasuryStockValue`	$802.49M	USD	Point-in-time
Treasury stock, at cost (16,216,411 shares at December 31, 2024 and December 31, 2023)	`TreasuryStockValue`	$802.49M	USD	Point-in-time
Treasury stock, at cost (16,216,411 shares at December 31, 2024 and December 31, 2023)	`TreasuryStockValue`	$802.49M	USD	Point-in-time
Total stockholders equity	`StockholdersEquity`	$811.02M	USD	Point-in-time
Total stockholders equity	`StockholdersEquity`	$811.02M	USD	Point-in-time
Total stockholders equity	`StockholdersEquity`	$1.29B	USD	Point-in-time
Total stockholders equity	`StockholdersEquity`	$1.29B	USD	Point-in-time
Total stockholders equity	`StockholdersEquity`	$1.10B	USD	Point-in-time
Total stockholders equity	`StockholdersEquity`	$1.10B	USD	Point-in-time
Total stockholders equity	`StockholdersEquity`	$1.54B	USD	Point-in-time
Total stockholders equity	`StockholdersEquity`	$1.54B	USD	Point-in-time
Total liabilities and stockholders equity	`LiabilitiesAndStockholdersEquity`	$937.12M	USD	Point-in-time
Total liabilities and stockholders equity	`LiabilitiesAndStockholdersEquity`	$937.12M	USD	Point-in-time
Total liabilities and stockholders equity	`LiabilitiesAndStockholdersEquity`	$1.66B	USD	Point-in-time
Total liabilities and stockholders equity	`LiabilitiesAndStockholdersEquity`	$1.66B	USD	Point-in-time

Income Statement 108 line items

Line Item	Tag	Value	Unit	Period
Total revenue	`RevenueFromContractWithCustomerExcludingAssessedTax`	$36.50M	USD	Annual
Total revenue	`RevenueFromContractWithCustomerExcludingAssessedTax`	$36.50M	USD	Annual
Total revenue	`RevenueFromContractWithCustomerExcludingAssessedTax`	$26.82M	USD	Annual
Total revenue	`RevenueFromContractWithCustomerExcludingAssessedTax`	$26.82M	USD	Annual
Total revenue	`RevenueFromContractWithCustomerExcludingAssessedTax`	$14.24M	USD	Annual
Total revenue	`RevenueFromContractWithCustomerExcludingAssessedTax`	$14.24M	USD	Annual
Cost of sales	`CostOfGoodsAndServicesSold`	$1.70M	USD	Annual
Cost of sales	`CostOfGoodsAndServicesSold`	$1.70M	USD	Annual
Cost of sales	`CostOfGoodsAndServicesSold`	$4.17M	USD	Annual
Cost of sales	`CostOfGoodsAndServicesSold`	$4.17M	USD	Annual
Cost of sales	`CostOfGoodsAndServicesSold`	$2.88M	USD	Annual
Cost of sales	`CostOfGoodsAndServicesSold`	$2.88M	USD	Annual
Research and development	`ResearchAndDevelopmentExpense`	$301.29M	USD	Annual
Research and development	`ResearchAndDevelopmentExpense`	$301.29M	USD	Annual
Research and development	`ResearchAndDevelopmentExpense`	$279.91M	USD	Annual
Research and development	`ResearchAndDevelopmentExpense`	$279.91M	USD	Annual
Research and development	`ResearchAndDevelopmentExpense`	$295.53M	USD	Annual
Research and development	`ResearchAndDevelopmentExpense`	$295.53M	USD	Annual
Selling, general and administrative	`SellingGeneralAndAdministrativeExpense`	$156.78M	USD	Annual
Selling, general and administrative	`SellingGeneralAndAdministrativeExpense`	$156.78M	USD	Annual
Selling, general and administrative	`SellingGeneralAndAdministrativeExpense`	$121.67M	USD	Annual
Selling, general and administrative	`SellingGeneralAndAdministrativeExpense`	$121.67M	USD	Annual
Selling, general and administrative	`SellingGeneralAndAdministrativeExpense`	$119.90M	USD	Annual
Selling, general and administrative	`SellingGeneralAndAdministrativeExpense`	$119.90M	USD	Annual
Total operating expenses	`CostsAndExpenses`	$462.24M	USD	Annual
Total operating expenses	`CostsAndExpenses`	$462.24M	USD	Annual
Total operating expenses	`CostsAndExpenses`	$403.29M	USD	Annual
Total operating expenses	`CostsAndExpenses`	$403.29M	USD	Annual
Total operating expenses	`CostsAndExpenses`	$418.31M	USD	Annual
Total operating expenses	`CostsAndExpenses`	$418.31M	USD	Annual
Loss from operations	`OperatingIncomeLoss`	$-389.05M	USD	Annual
Loss from operations	`OperatingIncomeLoss`	$-389.05M	USD	Annual
Loss from operations	`OperatingIncomeLoss`	$-425.74M	USD	Annual
Loss from operations	`OperatingIncomeLoss`	$-425.74M	USD	Annual
Loss from operations	`OperatingIncomeLoss`	$-391.49M	USD	Annual
Loss from operations	`OperatingIncomeLoss`	$-391.49M	USD	Annual
Gain on sale of contingent payments	`GainLossOnSaleOfContingentPayments`	$127.85M	USD	Annual
Gain on sale of contingent payments	`GainLossOnSaleOfContingentPayments`	$127.85M	USD	Annual
Gain on sale of contingent payments	`GainLossOnSaleOfContingentPayments`	$889.14M	USD	Annual
Gain on sale of contingent payments	`GainLossOnSaleOfContingentPayments`	$889.14M	USD	Annual
Gain on sale of contingent payments	`GainLossOnSaleOfContingentPayments`	-	USD	Annual
Gain on sale of contingent payments	`GainLossOnSaleOfContingentPayments`	-	USD	Annual
Milestone payment from gain on sale of oncology business	`GainLossOnSaleOfBusiness`	-	USD	Annual
Milestone payment from gain on sale of oncology business	`GainLossOnSaleOfBusiness`	-	USD	Annual
Milestone payment from gain on sale of oncology business	`GainLossOnSaleOfBusiness`	$200.00M	USD	Annual
Milestone payment from gain on sale of oncology business	`GainLossOnSaleOfBusiness`	$200.00M	USD	Annual
Milestone payment from gain on sale of oncology business	`GainLossOnSaleOfBusiness`	-	USD	Annual
Milestone payment from gain on sale of oncology business	`GainLossOnSaleOfBusiness`	-	USD	Annual
Royalty income from gain on sale of oncology business	`RoyaltyIncomeNonoperating`	-	USD	Annual
Royalty income from gain on sale of oncology business	`RoyaltyIncomeNonoperating`	-	USD	Annual
Royalty income from gain on sale of oncology business	`RoyaltyIncomeNonoperating`	$9.85M	USD	Annual
Royalty income from gain on sale of oncology business	`RoyaltyIncomeNonoperating`	$9.85M	USD	Annual
Royalty income from gain on sale of oncology business	`RoyaltyIncomeNonoperating`	-	USD	Annual
Royalty income from gain on sale of oncology business	`RoyaltyIncomeNonoperating`	-	USD	Annual
Interest income, net	`InterestIncomeExpenseNonoperatingNet`	$48.08M	USD	Annual
Interest income, net	`InterestIncomeExpenseNonoperatingNet`	$48.08M	USD	Annual
Interest income, net	`InterestIncomeExpenseNonoperatingNet`	$12.79M	USD	Annual
Interest income, net	`InterestIncomeExpenseNonoperatingNet`	$12.79M	USD	Annual
Interest income, net	`InterestIncomeExpenseNonoperatingNet`	$33.34M	USD	Annual
Interest income, net	`InterestIncomeExpenseNonoperatingNet`	$33.34M	USD	Annual
Other income, net	`OtherNonoperatingIncomeExpense`	$6.05M	USD	Annual
Other income, net	`OtherNonoperatingIncomeExpense`	$6.05M	USD	Annual
Other income, net	`OtherNonoperatingIncomeExpense`	$6.49M	USD	Annual
Other income, net	`OtherNonoperatingIncomeExpense`	$6.49M	USD	Annual
Other income, net	`OtherNonoperatingIncomeExpense`	$6.75M	USD	Annual
Other income, net	`OtherNonoperatingIncomeExpense`	$6.75M	USD	Annual
Net income (loss) before taxes	`IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest`	$-352.09M	USD	Annual
Net income (loss) before taxes	`IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest`	$-352.09M	USD	Annual
Net income (loss) before taxes	`IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest`	$717.97M	USD	Annual
Net income (loss) before taxes	`IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest`	$717.97M	USD	Annual
Net income (loss) before taxes	`IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest`	$-231.80M	USD	Annual
Net income (loss) before taxes	`IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest`	$-231.80M	USD	Annual
Income tax expense	`IncomeTaxExpenseBenefit`	-	USD	Annual
Income tax expense	`IncomeTaxExpenseBenefit`	-	USD	Annual
Income tax expense	`IncomeTaxExpenseBenefit`	-	USD	Annual
Income tax expense	`IncomeTaxExpenseBenefit`	-	USD	Annual
Income tax expense	`IncomeTaxExpenseBenefit`	$44.24M	USD	Annual
Income tax expense	`IncomeTaxExpenseBenefit`	$44.24M	USD	Annual
Net income (loss)	`NetIncomeLoss`	$-352.09M	USD	Annual
Net income (loss)	`NetIncomeLoss`	$-352.09M	USD	Annual
Net income (loss)	`NetIncomeLoss`	$-231.80M	USD	Annual
Net income (loss)	`NetIncomeLoss`	$-231.80M	USD	Annual
Net income (loss)	`NetIncomeLoss`	$673.73M	USD	Annual
Net income (loss)	`NetIncomeLoss`	$673.73M	USD	Annual
Net income (loss) per share - basic (in usd per share)	`EarningsPerShareBasic`	$11.86	USD	Annual
Net income (loss) per share - basic (in usd per share)	`EarningsPerShareBasic`	$11.86	USD	Annual
Net income (loss) per share - basic (in usd per share)	`EarningsPerShareBasic`	$-4.23	USD	Annual
Net income (loss) per share - basic (in usd per share)	`EarningsPerShareBasic`	$-4.23	USD	Annual
Net income (loss) per share - basic (in usd per share)	`EarningsPerShareBasic`	$-6.33	USD	Annual
Net income (loss) per share - basic (in usd per share)	`EarningsPerShareBasic`	$-6.33	USD	Annual
Net income (loss) per share - diluted (in usd share)	`EarningsPerShareDiluted`	$-6.33	USD	Annual
Net income (loss) per share - diluted (in usd share)	`EarningsPerShareDiluted`	$-6.33	USD	Annual
Net income (loss) per share - diluted (in usd share)	`EarningsPerShareDiluted`	$-4.23	USD	Annual
Net income (loss) per share - diluted (in usd share)	`EarningsPerShareDiluted`	$-4.23	USD	Annual
Net income (loss) per share - diluted (in usd share)	`EarningsPerShareDiluted`	$11.64	USD	Annual
Net income (loss) per share - diluted (in usd share)	`EarningsPerShareDiluted`	$11.64	USD	Annual
Weighted-average number of common shares used in computing net income (loss) per share basic (in shares)	`WeightedAverageNumberOfSharesOutstandingBasic`	55.65M	shares	Annual
Weighted-average number of common shares used in computing net income (loss) per share basic (in shares)	`WeightedAverageNumberOfSharesOutstandingBasic`	55.65M	shares	Annual
Weighted-average number of common shares used in computing net income (loss) per share basic (in shares)	`WeightedAverageNumberOfSharesOutstandingBasic`	56.81M	shares	Annual
Weighted-average number of common shares used in computing net income (loss) per share basic (in shares)	`WeightedAverageNumberOfSharesOutstandingBasic`	56.81M	shares	Annual
Weighted-average number of common shares used in computing net income (loss) per share basic (in shares)	`WeightedAverageNumberOfSharesOutstandingBasic`	54.79M	shares	Annual
Weighted-average number of common shares used in computing net income (loss) per share basic (in shares)	`WeightedAverageNumberOfSharesOutstandingBasic`	54.79M	shares	Annual
Weighted-average number of common shares used in computing net income (loss) per share diluted (in shares)	`WeightedAverageNumberOfDilutedSharesOutstanding`	54.79M	shares	Annual
Weighted-average number of common shares used in computing net income (loss) per share diluted (in shares)	`WeightedAverageNumberOfDilutedSharesOutstanding`	54.79M	shares	Annual
Weighted-average number of common shares used in computing net income (loss) per share diluted (in shares)	`WeightedAverageNumberOfDilutedSharesOutstanding`	57.89M	shares	Annual
Weighted-average number of common shares used in computing net income (loss) per share diluted (in shares)	`WeightedAverageNumberOfDilutedSharesOutstanding`	57.89M	shares	Annual
Weighted-average number of common shares used in computing net income (loss) per share diluted (in shares)	`WeightedAverageNumberOfDilutedSharesOutstanding`	55.65M	shares	Annual
Weighted-average number of common shares used in computing net income (loss) per share diluted (in shares)	`WeightedAverageNumberOfDilutedSharesOutstanding`	55.65M	shares	Annual

Cash Flow Statement 220 line items

Line Item	Tag	Value	Unit	Period
Net income (loss)	`NetIncomeLoss`	$-352.09M	USD	Annual
Net income (loss)	`NetIncomeLoss`	$-352.09M	USD	Annual
Net income (loss)	`NetIncomeLoss`	$-231.80M	USD	Annual
Net income (loss)	`NetIncomeLoss`	$-231.80M	USD	Annual
Net income (loss)	`NetIncomeLoss`	$673.73M	USD	Annual
Net income (loss)	`NetIncomeLoss`	$673.73M	USD	Annual
Depreciation and amortization	`OtherDepreciationAndAmortization`	$6.62M	USD	Annual
Depreciation and amortization	`OtherDepreciationAndAmortization`	$6.62M	USD	Annual
Depreciation and amortization	`OtherDepreciationAndAmortization`	$8.56M	USD	Annual
Depreciation and amortization	`OtherDepreciationAndAmortization`	$8.56M	USD	Annual
Depreciation and amortization	`OtherDepreciationAndAmortization`	$5.65M	USD	Annual
Depreciation and amortization	`OtherDepreciationAndAmortization`	$5.65M	USD	Annual
Stock-based compensation expense	`ShareBasedCompensation`	$42.85M	USD	Annual
Stock-based compensation expense	`ShareBasedCompensation`	$42.85M	USD	Annual
Stock-based compensation expense	`ShareBasedCompensation`	$44.77M	USD	Annual
Stock-based compensation expense	`ShareBasedCompensation`	$44.77M	USD	Annual
Stock-based compensation expense	`ShareBasedCompensation`	$49.30M	USD	Annual
Stock-based compensation expense	`ShareBasedCompensation`	$49.30M	USD	Annual
Net accretion of discount on marketable securities	`AccretionAmortizationOfDiscountsAndPremiumsInvestments`	$5.05M	USD	Annual
Net accretion of discount on marketable securities	`AccretionAmortizationOfDiscountsAndPremiumsInvestments`	$5.05M	USD	Annual
Net accretion of discount on marketable securities	`AccretionAmortizationOfDiscountsAndPremiumsInvestments`	$1.20M	USD	Annual
Net accretion of discount on marketable securities	`AccretionAmortizationOfDiscountsAndPremiumsInvestments`	$1.20M	USD	Annual
Net accretion of discount on marketable securities	`AccretionAmortizationOfDiscountsAndPremiumsInvestments`	$14.49M	USD	Annual
Net accretion of discount on marketable securities	`AccretionAmortizationOfDiscountsAndPremiumsInvestments`	$14.49M	USD	Annual
Gain on sale of contingent payments	`GainLossOnSaleOfContingentPayments`	$127.85M	USD	Annual
Gain on sale of contingent payments	`GainLossOnSaleOfContingentPayments`	$127.85M	USD	Annual
Gain on sale of contingent payments	`GainLossOnSaleOfContingentPayments`	$889.14M	USD	Annual
Gain on sale of contingent payments	`GainLossOnSaleOfContingentPayments`	$889.14M	USD	Annual
Gain on sale of contingent payments	`GainLossOnSaleOfContingentPayments`	-	USD	Annual
Gain on sale of contingent payments	`GainLossOnSaleOfContingentPayments`	-	USD	Annual
Loss (gain) on disposal of property and equipment	`GainLossOnSaleOfPropertyPlantEquipment`	$48.00K	USD	Annual
Loss (gain) on disposal of property and equipment	`GainLossOnSaleOfPropertyPlantEquipment`	$48.00K	USD	Annual
Loss (gain) on disposal of property and equipment	`GainLossOnSaleOfPropertyPlantEquipment`	$39.00K	USD	Annual
Loss (gain) on disposal of property and equipment	`GainLossOnSaleOfPropertyPlantEquipment`	$39.00K	USD	Annual
Loss (gain) on disposal of property and equipment	`GainLossOnSaleOfPropertyPlantEquipment`	$-553.00K	USD	Annual
Loss (gain) on disposal of property and equipment	`GainLossOnSaleOfPropertyPlantEquipment`	$-553.00K	USD	Annual
Non-cash operating lease expense	`OperatingLeaseRightOfUseAssetAmortizationExpense`	$11.53M	USD	Annual
Non-cash operating lease expense	`OperatingLeaseRightOfUseAssetAmortizationExpense`	$11.53M	USD	Annual
Non-cash operating lease expense	`OperatingLeaseRightOfUseAssetAmortizationExpense`	$9.99M	USD	Annual
Non-cash operating lease expense	`OperatingLeaseRightOfUseAssetAmortizationExpense`	$9.99M	USD	Annual
Non-cash operating lease expense	`OperatingLeaseRightOfUseAssetAmortizationExpense`	$10.72M	USD	Annual
Non-cash operating lease expense	`OperatingLeaseRightOfUseAssetAmortizationExpense`	$10.72M	USD	Annual
Expense associated with license agreement	`ExpenseAssociatedWithLicenseAgreement`	-	USD	Annual
Expense associated with license agreement	`ExpenseAssociatedWithLicenseAgreement`	-	USD	Annual
Expense associated with license agreement	`ExpenseAssociatedWithLicenseAgreement`	$17.50M	USD	Annual
Expense associated with license agreement	`ExpenseAssociatedWithLicenseAgreement`	$17.50M	USD	Annual
Expense associated with license agreement	`ExpenseAssociatedWithLicenseAgreement`	-	USD	Annual
Expense associated with license agreement	`ExpenseAssociatedWithLicenseAgreement`	-	USD	Annual
Realized gain on investments	`RealizedGainOnInvestments`	$28.00K	USD	Annual
Realized gain on investments	`RealizedGainOnInvestments`	$28.00K	USD	Annual
Realized gain on investments	`RealizedGainOnInvestments`	$167.00K	USD	Annual
Realized gain on investments	`RealizedGainOnInvestments`	$167.00K	USD	Annual
Realized gain on investments	`RealizedGainOnInvestments`	-	USD	Annual
Realized gain on investments	`RealizedGainOnInvestments`	-	USD	Annual
Milestone payment from gain on sale of oncology business	`GainLossOnSaleOfBusiness`	-	USD	Annual
Milestone payment from gain on sale of oncology business	`GainLossOnSaleOfBusiness`	-	USD	Annual
Milestone payment from gain on sale of oncology business	`GainLossOnSaleOfBusiness`	$200.00M	USD	Annual
Milestone payment from gain on sale of oncology business	`GainLossOnSaleOfBusiness`	$200.00M	USD	Annual
Milestone payment from gain on sale of oncology business	`GainLossOnSaleOfBusiness`	-	USD	Annual
Milestone payment from gain on sale of oncology business	`GainLossOnSaleOfBusiness`	-	USD	Annual
Accounts receivable, net	`IncreaseDecreaseInAccountsReceivable`	$2.21M	USD	Annual
Accounts receivable, net	`IncreaseDecreaseInAccountsReceivable`	$2.21M	USD	Annual
Accounts receivable, net	`IncreaseDecreaseInAccountsReceivable`	$1.30M	USD	Annual
Accounts receivable, net	`IncreaseDecreaseInAccountsReceivable`	$1.30M	USD	Annual
Accounts receivable, net	`IncreaseDecreaseInAccountsReceivable`	$604.00K	USD	Annual
Accounts receivable, net	`IncreaseDecreaseInAccountsReceivable`	$604.00K	USD	Annual
Inventory	`IncreaseDecreaseInInventories`	$10.58M	USD	Annual
Inventory	`IncreaseDecreaseInInventories`	$10.58M	USD	Annual
Inventory	`IncreaseDecreaseInInventories`	$8.49M	USD	Annual
Inventory	`IncreaseDecreaseInInventories`	$8.49M	USD	Annual
Inventory	`IncreaseDecreaseInInventories`	$8.54M	USD	Annual
Inventory	`IncreaseDecreaseInInventories`	$8.54M	USD	Annual
Other receivables	`IncreaseDecreaseInContractWithCustomerAsset`	$-447.00K	USD	Annual
Other receivables	`IncreaseDecreaseInContractWithCustomerAsset`	$-447.00K	USD	Annual
Other receivables	`IncreaseDecreaseInContractWithCustomerAsset`	-	USD	Annual
Other receivables	`IncreaseDecreaseInContractWithCustomerAsset`	-	USD	Annual
Other receivables	`IncreaseDecreaseInContractWithCustomerAsset`	-	USD	Annual
Other receivables	`IncreaseDecreaseInContractWithCustomerAsset`	-	USD	Annual
Prepaid expenses and other current and non-current assets	`IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets`	$5.81M	USD	Annual
Prepaid expenses and other current and non-current assets	`IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets`	$5.81M	USD	Annual
Prepaid expenses and other current and non-current assets	`IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets`	$-3.83M	USD	Annual
Prepaid expenses and other current and non-current assets	`IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets`	$-3.83M	USD	Annual
Prepaid expenses and other current and non-current assets	`IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets`	$176.00K	USD	Annual
Prepaid expenses and other current and non-current assets	`IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets`	$176.00K	USD	Annual
Accounts payable	`IncreaseDecreaseInAccountsPayable`	$-8.73M	USD	Annual
Accounts payable	`IncreaseDecreaseInAccountsPayable`	$-8.73M	USD	Annual
Accounts payable	`IncreaseDecreaseInAccountsPayable`	$6.60M	USD	Annual
Accounts payable	`IncreaseDecreaseInAccountsPayable`	$6.60M	USD	Annual
Accounts payable	`IncreaseDecreaseInAccountsPayable`	$3.44M	USD	Annual
Accounts payable	`IncreaseDecreaseInAccountsPayable`	$3.44M	USD	Annual
Accrued expenses	`IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities`	$12.82M	USD	Annual
Accrued expenses	`IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities`	$12.82M	USD	Annual
Accrued expenses	`IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities`	$3.69M	USD	Annual
Accrued expenses	`IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities`	$3.69M	USD	Annual
Accrued expenses	`IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities`	$-1.62M	USD	Annual
Accrued expenses	`IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities`	$-1.62M	USD	Annual
Income taxes payable	`IncreaseDecreaseInAccruedIncomeTaxesPayable`	$871.00K	USD	Annual
Income taxes payable	`IncreaseDecreaseInAccruedIncomeTaxesPayable`	$871.00K	USD	Annual
Income taxes payable	`IncreaseDecreaseInAccruedIncomeTaxesPayable`	-	USD	Annual
Income taxes payable	`IncreaseDecreaseInAccruedIncomeTaxesPayable`	-	USD	Annual
Income taxes payable	`IncreaseDecreaseInAccruedIncomeTaxesPayable`	-	USD	Annual
Income taxes payable	`IncreaseDecreaseInAccruedIncomeTaxesPayable`	-	USD	Annual
Operating lease liabilities	`IncreaseDecreaseInOperatingLeaseLiability`	$-15.01M	USD	Annual
Operating lease liabilities	`IncreaseDecreaseInOperatingLeaseLiability`	$-15.01M	USD	Annual
Operating lease liabilities	`IncreaseDecreaseInOperatingLeaseLiability`	$-10.83M	USD	Annual
Operating lease liabilities	`IncreaseDecreaseInOperatingLeaseLiability`	$-10.83M	USD	Annual
Operating lease liabilities	`IncreaseDecreaseInOperatingLeaseLiability`	$-13.66M	USD	Annual
Operating lease liabilities	`IncreaseDecreaseInOperatingLeaseLiability`	$-13.66M	USD	Annual
Other liabilities	`IncreaseDecreaseInOtherOperatingLiabilities`	$-276.00K	USD	Annual
Other liabilities	`IncreaseDecreaseInOtherOperatingLiabilities`	$-276.00K	USD	Annual
Other liabilities	`IncreaseDecreaseInOtherOperatingLiabilities`	$-2.12M	USD	Annual
Other liabilities	`IncreaseDecreaseInOtherOperatingLiabilities`	$-2.12M	USD	Annual
Other liabilities	`IncreaseDecreaseInOtherOperatingLiabilities`	$3.00M	USD	Annual
Other liabilities	`IncreaseDecreaseInOtherOperatingLiabilities`	$3.00M	USD	Annual
Net cash used in operating activities	`NetCashProvidedByUsedInOperatingActivities`	$-309.48M	USD	Annual
Net cash used in operating activities	`NetCashProvidedByUsedInOperatingActivities`	$-309.48M	USD	Annual
Net cash used in operating activities	`NetCashProvidedByUsedInOperatingActivities`	$-296.06M	USD	Annual
Net cash used in operating activities	`NetCashProvidedByUsedInOperatingActivities`	$-296.06M	USD	Annual
Net cash used in operating activities	`NetCashProvidedByUsedInOperatingActivities`	$-389.84M	USD	Annual
Net cash used in operating activities	`NetCashProvidedByUsedInOperatingActivities`	$-389.84M	USD	Annual
Purchases of marketable securities	`PaymentsToAcquireAvailableForSaleSecuritiesDebt`	$1.03B	USD	Annual
Purchases of marketable securities	`PaymentsToAcquireAvailableForSaleSecuritiesDebt`	$1.03B	USD	Annual
Purchases of marketable securities	`PaymentsToAcquireAvailableForSaleSecuritiesDebt`	$1.54B	USD	Annual
Purchases of marketable securities	`PaymentsToAcquireAvailableForSaleSecuritiesDebt`	$1.54B	USD	Annual
Purchases of marketable securities	`PaymentsToAcquireAvailableForSaleSecuritiesDebt`	$417.93M	USD	Annual
Purchases of marketable securities	`PaymentsToAcquireAvailableForSaleSecuritiesDebt`	$417.93M	USD	Annual
Proceeds from maturities and sales of marketable securities	`ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities`	$818.38M	USD	Annual
Proceeds from maturities and sales of marketable securities	`ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities`	$818.38M	USD	Annual
Proceeds from maturities and sales of marketable securities	`ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities`	$1.15B	USD	Annual
Proceeds from maturities and sales of marketable securities	`ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities`	$1.15B	USD	Annual
Proceeds from maturities and sales of marketable securities	`ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities`	$674.68M	USD	Annual
Proceeds from maturities and sales of marketable securities	`ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities`	$674.68M	USD	Annual
Proceeds from sale of contingent payments	`ProceedsFromSaleOfContingentPayments`	$131.78M	USD	Annual
Proceeds from sale of contingent payments	`ProceedsFromSaleOfContingentPayments`	$131.78M	USD	Annual
Proceeds from sale of contingent payments	`ProceedsFromSaleOfContingentPayments`	-	USD	Annual
Proceeds from sale of contingent payments	`ProceedsFromSaleOfContingentPayments`	-	USD	Annual
Proceeds from sale of contingent payments	`ProceedsFromSaleOfContingentPayments`	$889.14M	USD	Annual
Proceeds from sale of contingent payments	`ProceedsFromSaleOfContingentPayments`	$889.14M	USD	Annual
Proceeds from milestone payment from gain on sale of oncology business	`ProceedsFromDivestitureOfBusinesses`	$200.00M	USD	Annual
Proceeds from milestone payment from gain on sale of oncology business	`ProceedsFromDivestitureOfBusinesses`	$200.00M	USD	Annual
Proceeds from milestone payment from gain on sale of oncology business	`ProceedsFromDivestitureOfBusinesses`	-	USD	Annual
Proceeds from milestone payment from gain on sale of oncology business	`ProceedsFromDivestitureOfBusinesses`	-	USD	Annual
Proceeds from milestone payment from gain on sale of oncology business	`ProceedsFromDivestitureOfBusinesses`	-	USD	Annual
Proceeds from milestone payment from gain on sale of oncology business	`ProceedsFromDivestitureOfBusinesses`	-	USD	Annual
Payments associated with license agreement	`PaymentsAssociatedWithLicenseAgreement`	-	USD	Annual
Payments associated with license agreement	`PaymentsAssociatedWithLicenseAgreement`	-	USD	Annual
Payments associated with license agreement	`PaymentsAssociatedWithLicenseAgreement`	$17.50M	USD	Annual
Payments associated with license agreement	`PaymentsAssociatedWithLicenseAgreement`	$17.50M	USD	Annual
Payments associated with license agreement	`PaymentsAssociatedWithLicenseAgreement`	-	USD	Annual
Payments associated with license agreement	`PaymentsAssociatedWithLicenseAgreement`	-	USD	Annual
Purchases of property and equipment	`PaymentsToAcquirePropertyPlantAndEquipment`	$999.00K	USD	Annual
Purchases of property and equipment	`PaymentsToAcquirePropertyPlantAndEquipment`	$999.00K	USD	Annual
Purchases of property and equipment	`PaymentsToAcquirePropertyPlantAndEquipment`	$4.88M	USD	Annual
Purchases of property and equipment	`PaymentsToAcquirePropertyPlantAndEquipment`	$4.88M	USD	Annual
Purchases of property and equipment	`PaymentsToAcquirePropertyPlantAndEquipment`	$1.69M	USD	Annual
Purchases of property and equipment	`PaymentsToAcquirePropertyPlantAndEquipment`	$1.69M	USD	Annual
Proceeds from sale of equipment	`ProceedsFromSaleOfMachineryAndEquipment`	$1.32M	USD	Annual
Proceeds from sale of equipment	`ProceedsFromSaleOfMachineryAndEquipment`	$1.32M	USD	Annual
Proceeds from sale of equipment	`ProceedsFromSaleOfMachineryAndEquipment`	$964.00K	USD	Annual
Proceeds from sale of equipment	`ProceedsFromSaleOfMachineryAndEquipment`	$964.00K	USD	Annual
Proceeds from sale of equipment	`ProceedsFromSaleOfMachineryAndEquipment`	$40.00K	USD	Annual
Proceeds from sale of equipment	`ProceedsFromSaleOfMachineryAndEquipment`	$40.00K	USD	Annual
Net cash provided by investing activities	`NetCashProvidedByUsedInInvestingActivities`	$239.57M	USD	Annual
Net cash provided by investing activities	`NetCashProvidedByUsedInInvestingActivities`	$239.57M	USD	Annual
Net cash provided by investing activities	`NetCashProvidedByUsedInInvestingActivities`	$243.26M	USD	Annual
Net cash provided by investing activities	`NetCashProvidedByUsedInInvestingActivities`	$243.26M	USD	Annual
Net cash provided by investing activities	`NetCashProvidedByUsedInInvestingActivities`	$363.44M	USD	Annual
Net cash provided by investing activities	`NetCashProvidedByUsedInInvestingActivities`	$363.44M	USD	Annual
Payments on financing lease obligations	`FinanceLeasePrincipalPayments`	$331.00K	USD	Annual
Payments on financing lease obligations	`FinanceLeasePrincipalPayments`	$331.00K	USD	Annual
Payments on financing lease obligations	`FinanceLeasePrincipalPayments`	-	USD	Annual
Payments on financing lease obligations	`FinanceLeasePrincipalPayments`	-	USD	Annual
Payments on financing lease obligations	`FinanceLeasePrincipalPayments`	-	USD	Annual
Payments on financing lease obligations	`FinanceLeasePrincipalPayments`	-	USD	Annual
Net proceeds from stock option exercises and employee stock purchase plan	`ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions`	$5.43M	USD	Annual
Net proceeds from stock option exercises and employee stock purchase plan	`ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions`	$5.43M	USD	Annual
Net proceeds from stock option exercises and employee stock purchase plan	`ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions`	$2.68M	USD	Annual
Net proceeds from stock option exercises and employee stock purchase plan	`ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions`	$2.68M	USD	Annual
Net proceeds from stock option exercises and employee stock purchase plan	`ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions`	$14.44M	USD	Annual
Net proceeds from stock option exercises and employee stock purchase plan	`ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions`	$14.44M	USD	Annual
Net cash provided by financing activities	`NetCashProvidedByUsedInFinancingActivities`	$2.35M	USD	Annual
Net cash provided by financing activities	`NetCashProvidedByUsedInFinancingActivities`	$2.35M	USD	Annual
Net cash provided by financing activities	`NetCashProvidedByUsedInFinancingActivities`	$14.44M	USD	Annual
Net cash provided by financing activities	`NetCashProvidedByUsedInFinancingActivities`	$14.44M	USD	Annual
Net cash provided by financing activities	`NetCashProvidedByUsedInFinancingActivities`	$5.43M	USD	Annual
Net cash provided by financing activities	`NetCashProvidedByUsedInFinancingActivities`	$5.43M	USD	Annual
Net change in cash and cash equivalents	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect`	$-11.96M	USD	Annual
Net change in cash and cash equivalents	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect`	$-11.96M	USD	Annual
Net change in cash and cash equivalents	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect`	$-63.87M	USD	Annual
Net change in cash and cash equivalents	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect`	$-63.87M	USD	Annual
Net change in cash and cash equivalents	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect`	$-51.05M	USD	Annual
Net change in cash and cash equivalents	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect`	$-51.05M	USD	Annual
Cash and cash equivalents at beginning of the period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$139.26M	USD	Point-in-time
Cash and cash equivalents at beginning of the period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$139.26M	USD	Point-in-time
Cash and cash equivalents at beginning of the period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$76.25M	USD	Point-in-time
Cash and cash equivalents at beginning of the period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$76.25M	USD	Point-in-time
Cash and cash equivalents at beginning of the period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$88.20M	USD	Point-in-time
Cash and cash equivalents at beginning of the period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$88.20M	USD	Point-in-time
Cash and cash equivalents at beginning of the period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$203.13M	USD	Point-in-time
Cash and cash equivalents at beginning of the period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$203.13M	USD	Point-in-time
Cash and cash equivalents at end of the period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$139.26M	USD	Point-in-time
Cash and cash equivalents at end of the period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$139.26M	USD	Point-in-time
Cash and cash equivalents at end of the period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$76.25M	USD	Point-in-time
Cash and cash equivalents at end of the period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$76.25M	USD	Point-in-time
Cash and cash equivalents at end of the period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$88.20M	USD	Point-in-time
Cash and cash equivalents at end of the period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$88.20M	USD	Point-in-time
Cash and cash equivalents at end of the period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$203.13M	USD	Point-in-time
Cash and cash equivalents at end of the period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents`	$203.13M	USD	Point-in-time
Additions to property and equipment in accounts payable and accrued expenses	`CapitalExpendituresIncurredButNotYetPaid`	$158.00K	USD	Annual
Additions to property and equipment in accounts payable and accrued expenses	`CapitalExpendituresIncurredButNotYetPaid`	$158.00K	USD	Annual
Additions to property and equipment in accounts payable and accrued expenses	`CapitalExpendituresIncurredButNotYetPaid`	$55.00K	USD	Annual
Additions to property and equipment in accounts payable and accrued expenses	`CapitalExpendituresIncurredButNotYetPaid`	$55.00K	USD	Annual
Additions to property and equipment in accounts payable and accrued expenses	`CapitalExpendituresIncurredButNotYetPaid`	$317.00K	USD	Annual
Additions to property and equipment in accounts payable and accrued expenses	`CapitalExpendituresIncurredButNotYetPaid`	$317.00K	USD	Annual
Net cash taxes paid	`IncomeTaxesPaid`	-	USD	Annual
Net cash taxes paid	`IncomeTaxesPaid`	-	USD	Annual
Net cash taxes paid	`IncomeTaxesPaid`	$43.15M	USD	Annual
Net cash taxes paid	`IncomeTaxesPaid`	$43.15M	USD	Annual
Net cash taxes paid	`IncomeTaxesPaid`	$1.57M	USD	Annual
Net cash taxes paid	`IncomeTaxesPaid`	$1.57M	USD	Annual

Stockholders Equity 58 line items

Line Item	Tag	Value	Unit	Period
Common stock, beginning balance (in shares)	`CommonStockSharesOutstanding`	57.16M	shares	Point-in-time
Common stock, beginning balance (in shares)	`CommonStockSharesOutstanding`	57.16M	shares	Point-in-time
Common stock, beginning balance (in shares)	`CommonStockSharesOutstanding`	55.95M	shares	Point-in-time
Common stock, beginning balance (in shares)	`CommonStockSharesOutstanding`	55.95M	shares	Point-in-time
Beginning balance	`StockholdersEquity`	$811.02M	USD	Point-in-time
Beginning balance	`StockholdersEquity`	$811.02M	USD	Point-in-time
Beginning balance	`StockholdersEquity`	$1.29B	USD	Point-in-time
Beginning balance	`StockholdersEquity`	$1.29B	USD	Point-in-time
Beginning balance	`StockholdersEquity`	$1.10B	USD	Point-in-time
Beginning balance	`StockholdersEquity`	$1.10B	USD	Point-in-time
Beginning balance	`StockholdersEquity`	$1.54B	USD	Point-in-time
Beginning balance	`StockholdersEquity`	$1.54B	USD	Point-in-time
Treasury stock, beginning balance (in shares)	`TreasuryStockCommonShares`	16.22M	shares	Point-in-time
Treasury stock, beginning balance (in shares)	`TreasuryStockCommonShares`	16.22M	shares	Point-in-time
Treasury stock, beginning balance (in shares)	`TreasuryStockCommonShares`	16.22M	shares	Point-in-time
Treasury stock, beginning balance (in shares)	`TreasuryStockCommonShares`	16.22M	shares	Point-in-time
Unrealized gain (loss) on available-for-sale securities	`OtherComprehensiveIncomeLossAvailableForSaleSecuritiesBeforeReclassificationAdjustmentsTax`	$11.34M	USD	Annual
Unrealized gain (loss) on available-for-sale securities	`OtherComprehensiveIncomeLossAvailableForSaleSecuritiesBeforeReclassificationAdjustmentsTax`	$11.34M	USD	Annual
Unrealized gain (loss) on available-for-sale securities	`OtherComprehensiveIncomeLossAvailableForSaleSecuritiesBeforeReclassificationAdjustmentsTax`	$1.08M	USD	Annual
Unrealized gain (loss) on available-for-sale securities	`OtherComprehensiveIncomeLossAvailableForSaleSecuritiesBeforeReclassificationAdjustmentsTax`	$1.08M	USD	Annual
Unrealized gain (loss) on available-for-sale securities	`OtherComprehensiveIncomeLossAvailableForSaleSecuritiesBeforeReclassificationAdjustmentsTax`	$-12.09M	USD	Annual
Unrealized gain (loss) on available-for-sale securities	`OtherComprehensiveIncomeLossAvailableForSaleSecuritiesBeforeReclassificationAdjustmentsTax`	$-12.09M	USD	Annual
Net income (loss)	`NetIncomeLoss`	$-352.09M	USD	Annual
Net income (loss)	`NetIncomeLoss`	$-352.09M	USD	Annual
Net income (loss)	`NetIncomeLoss`	$-231.80M	USD	Annual
Net income (loss)	`NetIncomeLoss`	$-231.80M	USD	Annual
Net income (loss)	`NetIncomeLoss`	$673.73M	USD	Annual
Net income (loss)	`NetIncomeLoss`	$673.73M	USD	Annual
Stock-based compensation expense	`AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue`	$49.30M	USD	Annual
Stock-based compensation expense	`AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue`	$49.30M	USD	Annual
Stock-based compensation expense	`AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue`	$42.85M	USD	Annual
Stock-based compensation expense	`AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue`	$42.85M	USD	Annual
Stock-based compensation expense	`AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue`	$44.77M	USD	Annual
Stock-based compensation expense	`AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue`	$44.77M	USD	Annual
Common stock issued under stock incentive plan and ESPP (in shares)	`StockIssuedDuringPeriodSharesStockOptionsExercised`	343,341.00	shares	Annual
Common stock issued under stock incentive plan and ESPP (in shares)	`StockIssuedDuringPeriodSharesStockOptionsExercised`	343,341.00	shares	Annual
Common stock issued under stock incentive plan and ESPP	`StockIssuedDuringPeriodValueStockOptionsExercised`	$2.68M	USD	Annual
Common stock issued under stock incentive plan and ESPP	`StockIssuedDuringPeriodValueStockOptionsExercised`	$2.68M	USD	Annual
Common stock issued under stock incentive plan and ESPP	`StockIssuedDuringPeriodValueStockOptionsExercised`	$14.44M	USD	Annual
Common stock issued under stock incentive plan and ESPP	`StockIssuedDuringPeriodValueStockOptionsExercised`	$14.44M	USD	Annual
Common stock issued under stock incentive plan and ESPP	`StockIssuedDuringPeriodValueStockOptionsExercised`	$5.43M	USD	Annual
Common stock issued under stock incentive plan and ESPP	`StockIssuedDuringPeriodValueStockOptionsExercised`	$5.43M	USD	Annual
Common stock, ending balance (in shares)	`CommonStockSharesOutstanding`	57.16M	shares	Point-in-time
Common stock, ending balance (in shares)	`CommonStockSharesOutstanding`	57.16M	shares	Point-in-time
Common stock, ending balance (in shares)	`CommonStockSharesOutstanding`	55.95M	shares	Point-in-time
Common stock, ending balance (in shares)	`CommonStockSharesOutstanding`	55.95M	shares	Point-in-time
Ending balance	`StockholdersEquity`	$811.02M	USD	Point-in-time
Ending balance	`StockholdersEquity`	$811.02M	USD	Point-in-time
Ending balance	`StockholdersEquity`	$1.29B	USD	Point-in-time
Ending balance	`StockholdersEquity`	$1.29B	USD	Point-in-time
Ending balance	`StockholdersEquity`	$1.10B	USD	Point-in-time
Ending balance	`StockholdersEquity`	$1.10B	USD	Point-in-time
Ending balance	`StockholdersEquity`	$1.54B	USD	Point-in-time
Ending balance	`StockholdersEquity`	$1.54B	USD	Point-in-time
Treasury stock, ending balance (in shares)	`TreasuryStockCommonShares`	16.22M	shares	Point-in-time
Treasury stock, ending balance (in shares)	`TreasuryStockCommonShares`	16.22M	shares	Point-in-time
Treasury stock, ending balance (in shares)	`TreasuryStockCommonShares`	16.22M	shares	Point-in-time
Treasury stock, ending balance (in shares)	`TreasuryStockCommonShares`	16.22M	shares	Point-in-time

Comprehensive Income 18 line items

Line Item	Tag	Value	Unit	Period
Net income (loss)	`NetIncomeLoss`	$-352.09M	USD	Annual
Net income (loss)	`NetIncomeLoss`	$-352.09M	USD	Annual
Net income (loss)	`NetIncomeLoss`	$-231.80M	USD	Annual
Net income (loss)	`NetIncomeLoss`	$-231.80M	USD	Annual
Net income (loss)	`NetIncomeLoss`	$673.73M	USD	Annual
Net income (loss)	`NetIncomeLoss`	$673.73M	USD	Annual
Unrealized (loss) gain on available-for-sale securities	`OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax`	$-1.08M	USD	Annual
Unrealized (loss) gain on available-for-sale securities	`OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax`	$-1.08M	USD	Annual
Unrealized (loss) gain on available-for-sale securities	`OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax`	$-11.34M	USD	Annual
Unrealized (loss) gain on available-for-sale securities	`OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax`	$-11.34M	USD	Annual
Unrealized (loss) gain on available-for-sale securities	`OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax`	$12.09M	USD	Annual
Unrealized (loss) gain on available-for-sale securities	`OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax`	$12.09M	USD	Annual
Comprehensive income (loss)	`ComprehensiveIncomeNetOfTax`	$-339.99M	USD	Annual
Comprehensive income (loss)	`ComprehensiveIncomeNetOfTax`	$-339.99M	USD	Annual
Comprehensive income (loss)	`ComprehensiveIncomeNetOfTax`	$672.65M	USD	Annual
Comprehensive income (loss)	`ComprehensiveIncomeNetOfTax`	$672.65M	USD	Annual
Comprehensive income (loss)	`ComprehensiveIncomeNetOfTax`	$-243.14M	USD	Annual
Comprehensive income (loss)	`ComprehensiveIncomeNetOfTax`	$-243.14M	USD	Annual

Data is extracted from SEC EDGAR XBRL filings. Values shown are as reported in the filing.