10-K Filing

REGENXBIO INC. CIK: 1590877 FY 2021

Filing Information

Form Type	10-K
Accession Number	`0001564590-22-008055`
Period End Date	20211231
Filing Date	20220301
Fiscal Year	2021
Fiscal Period	FY
XBRL Instance	rgnx-10k_20211231_htm.xml

Filing Contents

This filing contains the following financial statements:

Balance Sheet 85 Income Statement 62 Cash Flow Statement 112 Stockholders Equity 24

Balance Sheet 85 line items

Line Item	Tag	Value	Unit	Period
Accounts receivable, allowance for credit loss, current	`AllowanceForDoubtfulAccountsReceivableCurrent`	$3.76M	USD	Point-in-time
Accounts receivable, allowance for credit loss, current	`AllowanceForDoubtfulAccountsReceivableCurrent`	$7.68M	USD	Point-in-time
Preferred stock, par value	`PreferredStockParOrStatedValuePerShare`	$0.00	USD	Point-in-time
Preferred stock, par value	`PreferredStockParOrStatedValuePerShare`	$0.00	USD	Point-in-time
Cash and cash equivalents	`CashAndCashEquivalentsAtCarryingValue`	$338.43M	USD	Point-in-time
Preferred stock, shares authorized	`PreferredStockSharesAuthorized`	10.00M	shares	Point-in-time
Cash and cash equivalents	`CashAndCashEquivalentsAtCarryingValue`	$345.21M	USD	Point-in-time
Cash and cash equivalents	`CashAndCashEquivalentsAtCarryingValue`	$69.51M	USD	Point-in-time
Preferred stock, shares authorized	`PreferredStockSharesAuthorized`	10.00M	shares	Point-in-time
Marketable securities	`MarketableSecuritiesCurrent`	$137.31M	USD	Point-in-time
Preferred stock, shares issued	`PreferredStockSharesIssued`	0.00	shares	Point-in-time
Marketable securities	`MarketableSecuritiesCurrent`	$112.23M	USD	Point-in-time
Preferred stock, shares issued	`PreferredStockSharesIssued`	0.00	shares	Point-in-time
Preferred stock, shares outstanding	`PreferredStockSharesOutstanding`	0.00	shares	Point-in-time
Accounts receivable (net of allowance of $7,678 as of December 31, 2020)	`AccountsReceivableNetCurrent`	$43.00M	USD	Point-in-time
Accounts receivable (net of allowance of $7,678 as of December 31, 2020)	`AccountsReceivableNetCurrent`	$32.44M	USD	Point-in-time
Preferred stock, shares outstanding	`PreferredStockSharesOutstanding`	0.00	shares	Point-in-time
Prepaid expenses	`PrepaidExpenseCurrent`	$18.75M	USD	Point-in-time
Common stock, par value	`CommonStockParOrStatedValuePerShare`	$0.00	USD	Point-in-time
Prepaid expenses	`PrepaidExpenseCurrent`	$10.51M	USD	Point-in-time
Common stock, par value	`CommonStockParOrStatedValuePerShare`	$0.00	USD	Point-in-time
Other current assets	`OtherAssetsCurrent`	$10.20M	USD	Point-in-time
Common stock, shares authorized	`CommonStockSharesAuthorized`	100.00M	shares	Point-in-time
Other current assets	`OtherAssetsCurrent`	$1.95M	USD	Point-in-time
Common stock, shares authorized	`CommonStockSharesAuthorized`	100.00M	shares	Point-in-time
Common stock, shares issued	`CommonStockSharesIssued`	42.83M	shares	Point-in-time
Common stock, shares issued	`CommonStockSharesIssued`	37.48M	shares	Point-in-time
Total current assets	`AssetsCurrent`	$531.20M	USD	Point-in-time
Total current assets	`AssetsCurrent`	$518.83M	USD	Point-in-time
Marketable securities	`MarketableSecuritiesNoncurrent`	$391.91M	USD	Point-in-time
Common stock, shares outstanding	`CommonStockSharesOutstanding`	42.83M	shares	Point-in-time
Common stock, shares outstanding	`CommonStockSharesOutstanding`	37.48M	shares	Point-in-time
Marketable securities	`MarketableSecuritiesNoncurrent`	$46.81M	USD	Point-in-time
Accounts receivable (net of allowance of $3,758 as of December 31, 2021)	`AccountsReceivableNetNoncurrent`	$3.27M	USD	Point-in-time
Accounts receivable (net of allowance of $3,758 as of December 31, 2021)	`AccountsReceivableNetNoncurrent`	$2.26M	USD	Point-in-time
Property and equipment, net	`PropertyPlantAndEquipmentNet`	$56.47M	USD	Point-in-time
Property and equipment, net	`PropertyPlantAndEquipmentNet`	$131.55M	USD	Point-in-time
Operating lease right-of-use assets	`OperatingLeaseRightOfUseAsset`	$63.81M	USD	Point-in-time
Operating lease right-of-use assets	`OperatingLeaseRightOfUseAsset`	$60.90M	USD	Point-in-time
Restricted cash	`RestrictedCashAndCashEquivalentsNoncurrent`	$1.33M	USD	Point-in-time
Restricted cash	`RestrictedCashAndCashEquivalentsNoncurrent`	$2.03M	USD	Point-in-time
Restricted cash	`RestrictedCashAndCashEquivalentsNoncurrent`	$1.33M	USD	Point-in-time
Other assets	`OtherAssetsNoncurrent`	$6.43M	USD	Point-in-time
Other assets	`OtherAssetsNoncurrent`	$5.28M	USD	Point-in-time
Total assets	`Assets`	$708.16M	USD	Point-in-time
Total assets	`Assets`	$1.11B	USD	Point-in-time
Accounts payable	`AccountsPayableCurrent`	$11.39M	USD	Point-in-time
Accounts payable	`AccountsPayableCurrent`	$10.62M	USD	Point-in-time
Accrued expenses and other current liabilities	`AccruedExpensesAndOtherCurrentLiabilities`	$76.11M	USD	Point-in-time
Accrued expenses and other current liabilities	`AccruedExpensesAndOtherCurrentLiabilities`	$49.08M	USD	Point-in-time
Deferred revenue	`ContractWithCustomerLiabilityCurrent`	$449.00K	USD	Point-in-time
Deferred revenue	`ContractWithCustomerLiabilityCurrent`	$3.33M	USD	Point-in-time
Operating lease liabilities	`OperatingLeaseLiabilityCurrent`	$1.75M	USD	Point-in-time
Operating lease liabilities	`OperatingLeaseLiabilityCurrent`	$2.50M	USD	Point-in-time
Liability related to sale of future royalties	`LiabilityRelatedToSaleOfFutureRoyaltiesCurrent`	$18.79M	USD	Point-in-time
Liability related to sale of future royalties	`LiabilityRelatedToSaleOfFutureRoyaltiesCurrent`	$37.89M	USD	Point-in-time
Total current liabilities	`LiabilitiesCurrent`	$81.45M	USD	Point-in-time
Total current liabilities	`LiabilitiesCurrent`	$130.47M	USD	Point-in-time
Deferred revenue	`ContractWithCustomerLiabilityNoncurrent`	$3.78M	USD	Point-in-time
Operating lease liabilities	`OperatingLeaseLiabilityNoncurrent`	$84.93M	USD	Point-in-time
Operating lease liabilities	`OperatingLeaseLiabilityNoncurrent`	$70.15M	USD	Point-in-time
Liability related to sale of future royalties	`LiabilityRelatedToSaleOfFutureRoyaltiesNonCurrent`	$133.46M	USD	Point-in-time
Liability related to sale of future royalties	`LiabilityRelatedToSaleOfFutureRoyaltiesNonCurrent`	$174.50M	USD	Point-in-time
Other liabilities	`OtherLiabilitiesNoncurrent`	$745.00K	USD	Point-in-time
Other liabilities	`OtherLiabilitiesNoncurrent`	$524.00K	USD	Point-in-time
Total liabilities	`Liabilities`	$349.61M	USD	Point-in-time
Total liabilities	`Liabilities`	$330.41M	USD	Point-in-time
Commitments and contingencies (Note 8)	`CommitmentsAndContingencies`	-	USD	Point-in-time
Commitments and contingencies (Note 8)	`CommitmentsAndContingencies`	-	USD	Point-in-time
Preferred stock; $0.0001 par value; 10,000 shares authorized, no shares issued and outstanding at December 31, 2021 and 2020	`PreferredStockValue`	-	USD	Point-in-time
Preferred stock; $0.0001 par value; 10,000 shares authorized, no shares issued and outstanding at December 31, 2021 and 2020	`PreferredStockValue`	-	USD	Point-in-time
Common stock; $0.0001 par value; 100,000 shares authorized at December 31, 2021 and 2020; 42,831 and 37,476 shares issued and outstanding at December 31, 2021 and 2020, respectively	`CommonStockValue`	$4.00K	USD	Point-in-time
Common stock; $0.0001 par value; 100,000 shares authorized at December 31, 2021 and 2020; 42,831 and 37,476 shares issued and outstanding at December 31, 2021 and 2020, respectively	`CommonStockValue`	$4.00K	USD	Point-in-time
Additional paid-in capital	`AdditionalPaidInCapitalCommonStock`	$667.18M	USD	Point-in-time
Additional paid-in capital	`AdditionalPaidInCapitalCommonStock`	$928.10M	USD	Point-in-time
Accumulated other comprehensive loss	`AccumulatedOtherComprehensiveIncomeLossNetOfTax`	$-360.00K	USD	Point-in-time
Accumulated other comprehensive loss	`AccumulatedOtherComprehensiveIncomeLossNetOfTax`	$-2.57M	USD	Point-in-time
Accumulated deficit	`RetainedEarningsAccumulatedDeficit`	$-161.23M	USD	Point-in-time
Accumulated deficit	`RetainedEarningsAccumulatedDeficit`	$-289.07M	USD	Point-in-time
Total stockholders equity	`StockholdersEquity`	$377.75M	USD	Point-in-time
Total stockholders equity	`StockholdersEquity`	$764.30M	USD	Point-in-time
Total stockholders equity	`StockholdersEquity`	$450.20M	USD	Point-in-time
Total stockholders equity	`StockholdersEquity`	$508.85M	USD	Point-in-time
Total liabilities and stockholders equity	`LiabilitiesAndStockholdersEquity`	$708.16M	USD	Point-in-time
Total liabilities and stockholders equity	`LiabilitiesAndStockholdersEquity`	$1.11B	USD	Point-in-time

Income Statement 62 line items

Line Item	Tag	Value	Unit	Period
Revenues	`RevenueFromContractWithCustomerExcludingAssessedTax`	$154.57M	USD	Annual
Revenues	`RevenueFromContractWithCustomerExcludingAssessedTax`	$470.35M	USD	Annual
Revenues	`RevenueFromContractWithCustomerExcludingAssessedTax`	$35.23M	USD	Annual
Cost of revenues	`CostOfGoodsAndServicesSold`	$8.24M	USD	Annual
Cost of revenues	`CostOfGoodsAndServicesSold`	$35.71M	USD	Annual
Cost of revenues	`CostOfGoodsAndServicesSold`	$51.83M	USD	Annual
Research and development	`ResearchAndDevelopmentExpense`	$181.44M	USD	Annual
Research and development	`ResearchAndDevelopmentExpense`	$124.19M	USD	Annual
Research and development	`ResearchAndDevelopmentExpense`	$166.29M	USD	Annual
General and administrative	`GeneralAndAdministrativeExpense`	$51.81M	USD	Annual
General and administrative	`GeneralAndAdministrativeExpense`	$79.33M	USD	Annual
General and administrative	`GeneralAndAdministrativeExpense`	$63.82M	USD	Annual
Credit losses (recoveries) and other	`CreditLossesRecoveriesAndOther`	$-10.00K	USD	Annual
Credit losses (recoveries) and other	`CreditLossesRecoveriesAndOther`	$7.97M	USD	Annual
Credit losses (recoveries) and other	`CreditLossesRecoveriesAndOther`	$-2.24M	USD	Annual
Total operating expenses	`CostsAndExpenses`	$273.80M	USD	Annual
Total operating expenses	`CostsAndExpenses`	$184.23M	USD	Annual
Total operating expenses	`CostsAndExpenses`	$310.37M	USD	Annual
Income (loss) from operations	`OperatingIncomeLoss`	$-119.23M	USD	Annual
Income (loss) from operations	`OperatingIncomeLoss`	$-149.00M	USD	Annual
Income (loss) from operations	`OperatingIncomeLoss`	$159.98M	USD	Annual
Interest income from licensing	`InterestIncomeFromLicencing`	$2.95M	USD	Annual
Interest income from licensing	`InterestIncomeFromLicencing`	$719.00K	USD	Annual
Interest income from licensing	`InterestIncomeFromLicencing`	$4.27M	USD	Annual
Investment income	`InvestmentIncomeNet`	$48.56M	USD	Annual
Investment income	`InvestmentIncomeNet`	$9.72M	USD	Annual
Investment income	`InvestmentIncomeNet`	$6.83M	USD	Annual
Interest expense	`InterestExpense`	$26.28M	USD	Annual
Interest expense	`InterestExpense`	$771.00K	USD	Annual
Total other income (expense)	`NonoperatingIncomeExpense`	$51.51M	USD	Annual
Total other income (expense)	`NonoperatingIncomeExpense`	$-18.73M	USD	Annual
Total other income (expense)	`NonoperatingIncomeExpense`	$13.22M	USD	Annual
Income (loss) before income taxes	`IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest`	$-106.01M	USD	Annual
Income (loss) before income taxes	`IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest`	$-97.49M	USD	Annual
Income (loss) before income taxes	`IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest`	$141.25M	USD	Annual
Income Tax Benefit (Expense)	`IncomeTaxExpenseBenefit`	$-2.75M	USD	Annual
Income Tax Benefit (Expense)	`IncomeTaxExpenseBenefit`	$5.24M	USD	Annual
Income Tax Benefit (Expense)	`IncomeTaxExpenseBenefit`	$13.41M	USD	Annual
Net income (loss)	`NetIncomeLoss`	$-111.25M	USD	Annual
Net income (loss)	`NetIncomeLoss`	$127.84M	USD	Annual
Net income (loss)	`NetIncomeLoss`	$-94.73M	USD	Annual
Unrealized gain (loss) on available-for-sale securities, net	`OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax`	$-565.00K	USD	Annual
Unrealized gain (loss) on available-for-sale securities, net	`OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax`	$-2.21M	USD	Annual
Unrealized gain (loss) on available-for-sale securities, net	`OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax`	$885.00K	USD	Annual
Total other comprehensive income (loss)	`OtherComprehensiveIncomeLossNetOfTax`	$885.00K	USD	Annual
Total other comprehensive income (loss)	`OtherComprehensiveIncomeLossNetOfTax`	$-2.21M	USD	Annual
Total other comprehensive income (loss)	`OtherComprehensiveIncomeLossNetOfTax`	$-565.00K	USD	Annual
Comprehensive income (loss)	`ComprehensiveIncomeNetOfTax`	$-111.81M	USD	Annual
Comprehensive income (loss)	`ComprehensiveIncomeNetOfTax`	$125.63M	USD	Annual
Comprehensive income (loss)	`ComprehensiveIncomeNetOfTax`	$-93.85M	USD	Annual
Basic	`EarningsPerShareBasic`	$-2.98	USD	Annual
Basic	`EarningsPerShareBasic`	$-2.58	USD	Annual
Basic	`EarningsPerShareBasic`	$3.01	USD	Annual
Diluted	`EarningsPerShareDiluted`	$2.91	USD	Annual
Diluted	`EarningsPerShareDiluted`	$-2.58	USD	Annual
Diluted	`EarningsPerShareDiluted`	$-2.98	USD	Annual
Basic	`WeightedAverageNumberOfSharesOutstandingBasic`	37.28M	shares	Annual
Basic	`WeightedAverageNumberOfSharesOutstandingBasic`	42.44M	shares	Annual
Basic	`WeightedAverageNumberOfSharesOutstandingBasic`	36.69M	shares	Annual
Diluted	`WeightedAverageNumberOfDilutedSharesOutstanding`	43.91M	shares	Annual
Diluted	`WeightedAverageNumberOfDilutedSharesOutstanding`	36.69M	shares	Annual
Diluted	`WeightedAverageNumberOfDilutedSharesOutstanding`	37.28M	shares	Annual

Cash Flow Statement 112 line items

Line Item	Tag	Value	Unit	Period
Net income (loss)	`ProfitLoss`	$-94.73M	USD	Annual
Net income (loss)	`ProfitLoss`	$-111.25M	USD	Annual
Net income (loss)	`ProfitLoss`	$127.84M	USD	Annual
Stock-based compensation expense	`ShareBasedCompensation`	$38.81M	USD	Annual
Stock-based compensation expense	`ShareBasedCompensation`	$26.85M	USD	Annual
Stock-based compensation expense	`ShareBasedCompensation`	$31.95M	USD	Annual
Depreciation and amortization	`DepreciationAndAmortization`	$9.56M	USD	Annual
Depreciation and amortization	`DepreciationAndAmortization`	$8.41M	USD	Annual
Depreciation and amortization	`DepreciationAndAmortization`	$7.15M	USD	Annual
Provision for credit losses (recoveries)	`ProvisionForOtherCreditLosses`	-	USD	Annual
Provision for credit losses (recoveries)	`ProvisionForOtherCreditLosses`	$-2.57M	USD	Annual
Provision for credit losses (recoveries)	`ProvisionForOtherCreditLosses`	$7.68M	USD	Annual
Net amortization of premiums (accretion of discounts) on marketable debt securities	`AccretionAmortizationOfDiscountsAndPremiumsInvestments`	$-5.84M	USD	Annual
Net amortization of premiums (accretion of discounts) on marketable debt securities	`AccretionAmortizationOfDiscountsAndPremiumsInvestments`	$-1.08M	USD	Annual
Net amortization of premiums (accretion of discounts) on marketable debt securities	`AccretionAmortizationOfDiscountsAndPremiumsInvestments`	$1.20M	USD	Annual
Net gains on investments	`GainLossOnInvestments`	$37.77M	USD	Annual
Net gains on investments	`GainLossOnInvestments`	$5.19M	USD	Annual
Net gains on investments	`GainLossOnInvestments`	$4.92M	USD	Annual
Imputed interest income from licensing	`ImputedInterestIncomeFromLicensing`	$2.95M	USD	Annual
Imputed interest income from licensing	`ImputedInterestIncomeFromLicensing`	$2.16M	USD	Annual
Imputed interest income from licensing	`ImputedInterestIncomeFromLicensing`	$360.00K	USD	Annual
Non-cash interest expense	`NonCashInterestExpense`	$4.64M	USD	Annual
Non-cash interest expense	`NonCashInterestExpense`	$771.00K	USD	Annual
Other non-cash adjustments	`OtherNoncashIncomeExpense`	$-268.00K	USD	Annual
Other non-cash adjustments	`OtherNoncashIncomeExpense`	$-79.00K	USD	Annual
Other non-cash adjustments	`OtherNoncashIncomeExpense`	$-163.00K	USD	Annual
Accounts receivable	`IncreaseDecreaseInAccountsReceivable`	$9.90M	USD	Annual
Accounts receivable	`IncreaseDecreaseInAccountsReceivable`	$-14.12M	USD	Annual
Accounts receivable	`IncreaseDecreaseInAccountsReceivable`	$8.62M	USD	Annual
Prepaid expenses	`IncreaseDecreaseInPrepaidExpense`	$4.03M	USD	Annual
Prepaid expenses	`IncreaseDecreaseInPrepaidExpense`	$8.25M	USD	Annual
Prepaid expenses	`IncreaseDecreaseInPrepaidExpense`	$973.00K	USD	Annual
Other current assets	`IncreaseDecreaseInOtherCurrentAssets`	$7.31M	USD	Annual
Other current assets	`IncreaseDecreaseInOtherCurrentAssets`	$499.00K	USD	Annual
Other current assets	`IncreaseDecreaseInOtherCurrentAssets`	$-2.34M	USD	Annual
Operating lease right-of-use assets	`IncreaseDecreaseInOperatingLeaseRightOfUseAssets`	$-3.22M	USD	Annual
Operating lease right-of-use assets	`IncreaseDecreaseInOperatingLeaseRightOfUseAssets`	$-2.43M	USD	Annual
Operating lease right-of-use assets	`IncreaseDecreaseInOperatingLeaseRightOfUseAssets`	$-4.87M	USD	Annual
Other assets	`IncreaseDecreaseInOtherNoncurrentAssets`	$2.69M	USD	Annual
Other assets	`IncreaseDecreaseInOtherNoncurrentAssets`	$2.27M	USD	Annual
Other assets	`IncreaseDecreaseInOtherNoncurrentAssets`	$-399.00K	USD	Annual
Accounts payable	`IncreaseDecreaseInAccountsPayableTrade`	$3.87M	USD	Annual
Accounts payable	`IncreaseDecreaseInAccountsPayableTrade`	$-2.30M	USD	Annual
Accounts payable	`IncreaseDecreaseInAccountsPayableTrade`	$1.53M	USD	Annual
Accrued expenses and other current liabilities	`IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities`	$6.88M	USD	Annual
Accrued expenses and other current liabilities	`IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities`	$17.40M	USD	Annual
Accrued expenses and other current liabilities	`IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities`	$29.91M	USD	Annual
Deferred revenue	`IncreaseDecreaseInDeferredRevenue`	$-600.00K	USD	Annual
Deferred revenue	`IncreaseDecreaseInDeferredRevenue`	$-899.00K	USD	Annual
Operating lease liabilities	`IncreaseDecreaseInOperatingLeaseLiabilities`	$12.07M	USD	Annual
Operating lease liabilities	`IncreaseDecreaseInOperatingLeaseLiabilities`	$-2.25M	USD	Annual
Operating lease liabilities	`IncreaseDecreaseInOperatingLeaseLiabilities`	$2.14M	USD	Annual
Other liabilities	`IncreaseDecreaseInOtherOperatingLiabilities`	$-523.00K	USD	Annual
Other liabilities	`IncreaseDecreaseInOtherOperatingLiabilities`	$-1.22M	USD	Annual
Other liabilities	`IncreaseDecreaseInOtherOperatingLiabilities`	$289.00K	USD	Annual
Net cash provided by (used in) operating activities	`NetCashProvidedByUsedInOperatingActivities`	$218.88M	USD	Annual
Net cash provided by (used in) operating activities	`NetCashProvidedByUsedInOperatingActivities`	$-107.70M	USD	Annual
Net cash provided by (used in) operating activities	`NetCashProvidedByUsedInOperatingActivities`	$-54.06M	USD	Annual
Purchases of marketable debt securities	`PaymentsToAcquireMarketableSecurities`	$190.74M	USD	Annual
Purchases of marketable debt securities	`PaymentsToAcquireMarketableSecurities`	$123.04M	USD	Annual
Purchases of marketable debt securities	`PaymentsToAcquireMarketableSecurities`	$498.14M	USD	Annual
Maturities of marketable debt securities	`ProceedsFromSaleAndMaturityOfMarketableSecurities`	$289.99M	USD	Annual
Maturities of marketable debt securities	`ProceedsFromSaleAndMaturityOfMarketableSecurities`	$170.09M	USD	Annual
Maturities of marketable debt securities	`ProceedsFromSaleAndMaturityOfMarketableSecurities`	$233.47M	USD	Annual
Sales of marketable debt securities	`ProceedsFromSalesOfMarketableDebtSecurities`	$2.29M	USD	Annual
Sales of equity securities	`ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities`	$6.02M	USD	Annual
Sales of equity securities	`ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities`	$5.59M	USD	Annual
Sales of equity securities	`ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities`	$36.91M	USD	Annual
Purchases of property and equipment	`PaymentsToAcquirePropertyPlantAndEquipment`	$26.87M	USD	Annual
Purchases of property and equipment	`PaymentsToAcquirePropertyPlantAndEquipment`	$84.17M	USD	Annual
Purchases of property and equipment	`PaymentsToAcquirePropertyPlantAndEquipment`	$11.72M	USD	Annual
Net cash provided by (used in) investing activities	`NetCashProvidedByUsedInInvestingActivities`	$-406.64M	USD	Annual
Net cash provided by (used in) investing activities	`NetCashProvidedByUsedInInvestingActivities`	$93.56M	USD	Annual
Net cash provided by (used in) investing activities	`NetCashProvidedByUsedInInvestingActivities`	$122.76M	USD	Annual
Proceeds from exercise of stock options	`ProceedsFromStockOptionsExercised`	$7.06M	USD	Annual
Proceeds from exercise of stock options	`ProceedsFromStockOptionsExercised`	$5.62M	USD	Annual
Proceeds from exercise of stock options	`ProceedsFromStockOptionsExercised`	$4.28M	USD	Annual
Taxes paid related to net settlement of stock options	`TaxesPaidRelatedToNetSettlementOfStockOptions`	$2.00K	USD	Annual
Proceeds from issuance of common stock under employee stock purchase plan	`ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlans`	$1.77M	USD	Annual
Proceeds from issuance of common stock under employee stock purchase plan	`ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlans`	$1.31M	USD	Annual
Proceeds from issuance of common stock under employee stock purchase plan	`ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlans`	$1.80M	USD	Annual
Proceeds from public offering of common stock, net of underwriting discounts and commissions	`ProceedsFromIssuancesOfCommonStockNetOfUnderwritingDiscountsAndCommissions`	$216.44M	USD	Annual
Issuance costs for public offering of common stock	`PaymentsOfStockIssuanceCosts`	$379.00K	USD	Annual
Proceeds from sale of future royalties	`ProceedsFromSaleOfFutureRoyalties`	$196.00M	USD	Annual
Repayments under liability related to sale of future royalties, net of imputed interest	`RepaymentsUnderLiabilityRelatedToSaleOfFutureRoyalties`	$26.59M	USD	Annual
Transaction costs for sale of future royalties	`PaymentsOfTransactionCostsForSaleOfFutureLoyalties`	$265.00K	USD	Annual
Transaction costs for sale of future royalties	`PaymentsOfTransactionCostsForSaleOfFutureLoyalties`	$3.21M	USD	Annual
Net cash provided by financing activities	`NetCashProvidedByUsedInFinancingActivities`	$195.25M	USD	Annual
Net cash provided by financing activities	`NetCashProvidedByUsedInFinancingActivities`	$8.38M	USD	Annual
Net cash provided by financing activities	`NetCashProvidedByUsedInFinancingActivities`	$200.21M	USD	Annual
Net increase (decrease) in cash and cash equivalents and restricted cash	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect`	$-5.77M	USD	Annual
Net increase (decrease) in cash and cash equivalents and restricted cash	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect`	$268.91M	USD	Annual
Net increase (decrease) in cash and cash equivalents and restricted cash	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect`	$7.48M	USD	Annual
Beginning of period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations`	$76.61M	USD	Point-in-time
Beginning of period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations`	$347.24M	USD	Point-in-time
Beginning of period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations`	$339.76M	USD	Point-in-time
Beginning of period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations`	$70.84M	USD	Point-in-time
End of period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations`	$76.61M	USD	Point-in-time
End of period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations`	$347.24M	USD	Point-in-time
End of period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations`	$339.76M	USD	Point-in-time
End of period	`CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations`	$70.84M	USD	Point-in-time
Cash paid (received) for income taxes	`IncomeTaxesPaidNet`	$-191.00K	USD	Annual
Cash paid (received) for income taxes	`IncomeTaxesPaidNet`	$6.00M	USD	Annual
Cash paid (received) for income taxes	`IncomeTaxesPaidNet`	$904.00K	USD	Annual
Cash paid for imputed interest under liability related to sale of future royalties	`CashPaidForImputedInterestUnderLiabilityRelatedToSaleOfFutureRoyalties`	$21.64M	USD	Annual
Increase in accounts payable and accrued liabilities related to purchases of property and equipment	`CapitalExpendituresIncurredButNotYetPaid`	$558.00K	USD	Annual
Increase in accounts payable and accrued liabilities related to purchases of property and equipment	`CapitalExpendituresIncurredButNotYetPaid`	$6.81M	USD	Annual
Increase in accounts payable and accrued liabilities related to purchases of property and equipment	`CapitalExpendituresIncurredButNotYetPaid`	$1.57M	USD	Annual
Non-cash additions to property and equipment through tenant improvement allowance	`NonCashAdditionsToPropertyAndEquipmentThroughTenantImprovementAllowance`	$2.26M	USD	Annual
Non-cash consideration received for licenses granted	`NoncashOrPartNoncashDivestitureAmountOfConsiderationReceived1`	$1.12M	USD	Annual
Transaction costs for sale of future royalties in accounts payable and other current liabilities	`LiabilitiesAssumed1`	$265.00K	USD	Annual
Proceeds due to Company from sales of non-marketable equity securities	`ProceedsDueToCompanyFromSalesOfNonMarketableEquitySecurities`	$600.00K	USD	Annual

Stockholders Equity 24 line items

Line Item	Tag	Value	Unit	Period
Balances	`StockholdersEquity`	$377.75M	USD	Point-in-time
Balances	`StockholdersEquity`	$764.30M	USD	Point-in-time
Balances	`StockholdersEquity`	$450.20M	USD	Point-in-time
Balances	`StockholdersEquity`	$508.85M	USD	Point-in-time
Issuance of common stock upon public offering, net of transaction costs	`StockIssuedDuringPeriodValueNewIssues`	$216.06M	USD	Annual
Exercise of stock options	`StockIssuedDuringPeriodValueStockOptionsExercised`	$4.28M	USD	Annual
Exercise of stock options	`StockIssuedDuringPeriodValueStockOptionsExercised`	$5.62M	USD	Annual
Exercise of stock options	`StockIssuedDuringPeriodValueStockOptionsExercised`	$7.06M	USD	Annual
Issuance of common stock under employee stock purchase plan	`StockIssuedDuringPeriodValueEmployeeStockPurchasePlan`	$1.77M	USD	Annual
Issuance of common stock under employee stock purchase plan	`StockIssuedDuringPeriodValueEmployeeStockPurchasePlan`	$1.31M	USD	Annual
Issuance of common stock under employee stock purchase plan	`StockIssuedDuringPeriodValueEmployeeStockPurchasePlan`	$1.80M	USD	Annual
Stock-based compensation expense	`AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue`	$31.95M	USD	Annual
Stock-based compensation expense	`AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue`	$26.85M	USD	Annual
Stock-based compensation expense	`AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue`	$38.81M	USD	Annual
Unrealized gain (loss) on available-for-sale securities, net	`OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax`	$-2.21M	USD	Annual
Unrealized gain (loss) on available-for-sale securities, net	`OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax`	$885.00K	USD	Annual
Unrealized gain (loss) on available-for-sale securities, net	`OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax`	$-565.00K	USD	Annual
Net income (loss)	`NetIncomeLoss`	$-111.25M	USD	Annual
Net income (loss)	`NetIncomeLoss`	$127.84M	USD	Annual
Net income (loss)	`NetIncomeLoss`	$-94.73M	USD	Annual
Balances	`StockholdersEquity`	$377.75M	USD	Point-in-time
Balances	`StockholdersEquity`	$764.30M	USD	Point-in-time
Balances	`StockholdersEquity`	$450.20M	USD	Point-in-time
Balances	`StockholdersEquity`	$508.85M	USD	Point-in-time

Data is extracted from SEC EDGAR XBRL filings. Values shown are as reported in the filing.